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MAP6D1 MAP6 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 79929, updated on 1-Mar-2024

Summary

Official Symbol
MAP6D1provided by HGNC
Official Full Name
MAP6 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25753
See related
Ensembl:ENSG00000180834 MIM:610593; AllianceGenome:HGNC:25753
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SL21; MAPO6D1
Summary
This gene encodes a protein highly similar to the mouse MAP6 domain containing 1 protein, which is related to the STOP proteins. Based on the study of the mouse protein, the encoded protein may function as a calmodulin-regulated neuronal protein that binds and stabilizes microtubules but also associates with the Golgi membranes through N-terminal palmitoylation. [provided by RefSeq, Oct 2008]
Expression
Biased expression in brain (RPKM 16.9), skin (RPKM 1.5) and 2 other tissues See more
Orthologs
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Genomic context

See MAP6D1 in Genome Data Viewer
Location:
3q27.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (183815922..183825577, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (186625430..186635070, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183533710..183543365, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14946 Neighboring gene kelch like family member 24 Neighboring gene NANOG hESC enhancer GRCh37_chr3:183384502-183385010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14947 Neighboring gene YEATS domain containing 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:183527422-183528621 Neighboring gene YEATS2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:183535409-183536020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14950 Neighboring gene presenilin associated rhomboid like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14951 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:183602698-183602848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20898 Neighboring gene microRNA 4448

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ12748

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Golgi-associated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
MAP6 domain-containing protein 1
Names
21 kDa STOP-like protein
STOP-Like protein 21 kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024871.4NP_079147.1  MAP6 domain-containing protein 1

    See identical proteins and their annotated locations for NP_079147.1

    Status: REVIEWED

    Source sequence(s)
    AK022810, BC006434
    Consensus CDS
    CCDS3247.1
    UniProtKB/Swiss-Prot
    Q9H9H5
    UniProtKB/TrEMBL
    C9JPF8
    Related
    ENSP00000314560.4, ENST00000318631.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    183815922..183825577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    186625430..186635070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)