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MAP6D1 MAP6 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 79929, updated on 2-Mar-2021

Summary

Official Symbol
MAP6D1provided by HGNC
Official Full Name
MAP6 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25753
See related
Ensembl:ENSG00000180834 MIM:610593
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SL21; MAPO6D1
Summary
This gene encodes a protein highly similar to the mouse MAP6 domain containing 1 protein, which is related to the STOP proteins. Based on the study of the mouse protein, the encoded protein may function as a calmodulin-regulated neuronal protein that binds and stabilizes microtubules but also associates with the Golgi membranes through N-terminal palmitoylation. [provided by RefSeq, Oct 2008]
Expression
Biased expression in brain (RPKM 16.9), skin (RPKM 1.5) and 2 other tissues See more
Orthologs
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Genomic context

See MAP6D1 in Genome Data Viewer
Location:
3q27.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (183815884..183825602, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183533710..183543365, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986162 Neighboring gene kelch like family member 24 Neighboring gene YEATS domain containing 2 Neighboring gene YEATS2 antisense RNA 1 Neighboring gene presenilin associated rhomboid like Neighboring gene microRNA 4448

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ12748

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
N-terminal peptidyl-L-cysteine N-palmitoylation IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
 
regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi-associated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MAP6 domain-containing protein 1
Names
21 kDa STOP-like protein
STOP-Like protein 21 kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024871.4NP_079147.1  MAP6 domain-containing protein 1

    See identical proteins and their annotated locations for NP_079147.1

    Status: REVIEWED

    Source sequence(s)
    AK022810, BC006434
    Consensus CDS
    CCDS3247.1
    UniProtKB/Swiss-Prot
    Q9H9H5
    Related
    ENSP00000314560.3, ENST00000318631.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    183815884..183825602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001740273.2 RNA Sequence

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