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ADM2 adrenomedullin 2 [ Homo sapiens (human) ]

Gene ID: 79924, updated on 28-Nov-2021

Summary

Official Symbol
ADM2provided by HGNC
Official Full Name
adrenomedullin 2provided by HGNC
Primary source
HGNC:HGNC:28898
See related
Ensembl:ENSG00000128165 MIM:608682
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AM2; dJ579N16.4
Summary
This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]
Expression
Biased expression in thyroid (RPKM 8.0), kidney (RPKM 5.1) and 12 other tissues See more
Orthologs
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Genomic context

See ADM2 in Genome Data Viewer
Location:
22q13.33
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (50481543..50486437)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50919972..50924866)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 2 Neighboring gene vegetative cell wall protein gp1-like Neighboring gene SET binding factor 1 Neighboring gene myo-inositol oxygenase Neighboring gene lipase maturation factor 2 Neighboring gene non-SMC condensin II complex subunit H2 Neighboring gene synthesis of cytochrome C oxidase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein ADM2
Names
intermedin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253845.2NP_001240774.1  protein ADM2 preproprotein

    See identical proteins and their annotated locations for NP_001240774.1

    Status: REVIEWED

    Source sequence(s)
    AB236970, AL096767, BC012864
    Consensus CDS
    CCDS33682.1
    UniProtKB/Swiss-Prot
    Q7Z4H4
    Related
    ENSP00000379086.1, ENST00000395737.2
    Conserved Domains (1) summary
    cl27728
    Location:107148
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  2. NM_001369882.1NP_001356811.1  protein ADM2 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AL096767
    Related
    ENSP00000379087.2, ENST00000395738.2
    Conserved Domains (1) summary
    cl27728
    Location:107148
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    50481543..50486437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024866.5: Suppressed sequence

    Description
    NM_024866.5: This RefSeq was removed because currently there is insufficient support for the transcript.
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