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TCEAL4 transcription elongation factor A like 4 [ Homo sapiens (human) ]

Gene ID: 79921, updated on 11-Jun-2021

Summary

Official Symbol
TCEAL4provided by HGNC
Official Full Name
transcription elongation factor A like 4provided by HGNC
Primary source
HGNC:HGNC:26121
See related
Ensembl:ENSG00000133142
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WEX7; NPD017
Summary
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. This family is comprised of nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternatively splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 13. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in ovary (RPKM 91.3), endometrium (RPKM 75.4) and 23 other tissues See more
Orthologs
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Genomic context

See TCEAL4 in Genome Data Viewer
Location:
Xq22.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (103576231..103587729)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102831159..102842657)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LL0XNC01-250H12.3 Neighboring gene RAB40A, member RAS oncogene family Neighboring gene long intergenic non-protein coding RNA 2589 Neighboring gene uncharacterized LOC105373302 Neighboring gene Sharpr-MPRA regulatory region 5968 Neighboring gene transcription elongation factor A like 3 Neighboring gene transcription elongation factor A like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21174, DKFZp686M0279

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables WW domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription elongation factor A protein-like 4
Names
TCEA-like protein 4
epididymis secretory sperm binding protein
transcription elongation factor A (SII)-like 4
transcription elongation factor S-II protein-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016315.2 RefSeqGene

    Range
    14255..16506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001006935.3NP_001006936.1  transcription elongation factor A protein-like 4 isoform 1

    See identical proteins and their annotated locations for NP_001006936.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF271783
    Consensus CDS
    CCDS14510.2
    UniProtKB/Swiss-Prot
    Q96EI5
    Related
    ENSP00000421156.1, ENST00000472484.6
    Conserved Domains (2) summary
    pfam04538
    Location:88190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7154
    Na_Ca_ex; Sodium/calcium exchanger protein
  2. NM_001006937.3NP_001006938.1  transcription elongation factor A protein-like 4 isoform 1

    See identical proteins and their annotated locations for NP_001006938.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF314542, AI879651, BP375855
    Consensus CDS
    CCDS14510.2
    UniProtKB/Swiss-Prot
    Q96EI5
    Related
    ENSP00000427494.1, ENST00000494801.5
    Conserved Domains (2) summary
    pfam04538
    Location:88190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7154
    Na_Ca_ex; Sodium/calcium exchanger protein
  3. NM_001300901.2NP_001287830.1  transcription elongation factor A protein-like 4 isoform 2

    See identical proteins and their annotated locations for NP_001287830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains multiple alternate exons in the 5' region, uses an alternate internal splice site, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a longer N-terminus than isoform 1.
    Source sequence(s)
    AF271783, AF314542, BX104938
    Consensus CDS
    CCDS76004.1
    UniProtKB/Swiss-Prot
    Q96EI5
    Related
    ENSP00000361712.4, ENST00000372629.4
    Conserved Domains (1) summary
    pfam04538
    Location:231333
    BEX; Brain expressed X-linked like family
  4. NM_001305840.2NP_001292769.1  transcription elongation factor A protein-like 4 isoform 1

    See identical proteins and their annotated locations for NP_001292769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site and contains an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF314542, AI879651, AL833640, AU253367
    Consensus CDS
    CCDS14510.2
    UniProtKB/Swiss-Prot
    Q96EI5
    Conserved Domains (2) summary
    pfam04538
    Location:88190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7154
    Na_Ca_ex; Sodium/calcium exchanger protein
  5. NM_001305841.2NP_001292770.1  transcription elongation factor A protein-like 4 isoform 1

    See identical proteins and their annotated locations for NP_001292770.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses two alternate splice sites and lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF314542, AI879651, BI084326
    Consensus CDS
    CCDS14510.2
    UniProtKB/Swiss-Prot
    Q96EI5
    Related
    ENSP00000415564.2, ENST00000415568.2
    Conserved Domains (2) summary
    pfam04538
    Location:88190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7154
    Na_Ca_ex; Sodium/calcium exchanger protein
  6. NM_001305842.2NP_001292771.1  transcription elongation factor A protein-like 4 isoform 1

    See identical proteins and their annotated locations for NP_001292771.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF314542, AI879651, AL833640, BF359447
    Consensus CDS
    CCDS14510.2
    UniProtKB/Swiss-Prot
    Q96EI5
    Conserved Domains (2) summary
    pfam04538
    Location:88190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7154
    Na_Ca_ex; Sodium/calcium exchanger protein
  7. NM_024863.6NP_079139.4  transcription elongation factor A protein-like 4 isoform 1

    See identical proteins and their annotated locations for NP_079139.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AI879651, AL833640
    Consensus CDS
    CCDS14510.2
    UniProtKB/Swiss-Prot
    Q96EI5
    Related
    ENSP00000421857.1, ENST00000468024.5
    Conserved Domains (2) summary
    pfam04538
    Location:88190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7154
    Na_Ca_ex; Sodium/calcium exchanger protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    103576231..103587729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029857.1XP_016885346.1  transcription elongation factor A protein-like 4 isoform X2

    UniProtKB/Swiss-Prot
    Q96EI5
    Related
    ENSP00000424314.1, ENST00000472745.1
    Conserved Domains (2) summary
    pfam04538
    Location:88190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7154
    Na_Ca_ex; Sodium/calcium exchanger protein
  2. XM_024452450.1XP_024308218.1  transcription elongation factor A protein-like 4 isoform X2

    Conserved Domains (2) summary
    pfam04538
    Location:88190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7154
    Na_Ca_ex; Sodium/calcium exchanger protein
  3. XM_017029856.1XP_016885345.1  transcription elongation factor A protein-like 4 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006936.1: Suppressed sequence

    Description
    NM_001006936.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support the use of a non-consensus splice site in the 5' UTR.
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