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MAGIX MAGI family member, X-linked [ Homo sapiens (human) ]

Gene ID: 79917, updated on 1-Jun-2020

Summary

Official Symbol
MAGIXprovided by HGNC
Official Full Name
MAGI family member, X-linkedprovided by HGNC
Primary source
HGNC:HGNC:30006
See related
Ensembl:ENSG00000269313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JM10; PDZX
Expression
Ubiquitous expression in stomach (RPKM 1.5), kidney (RPKM 1.3) and 25 other tissues See more
Orthologs

Genomic context

See MAGIX in Genome Data Viewer
Location:
Xp11.23
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (49162569..49168157)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (49019181..49023836)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373195 Neighboring gene RNA, 7SL, cytoplasmic 262, pseudogene Neighboring gene ZFP161 motif-containing MPRA enhancer 76/77 Neighboring gene prickle planar cell polarity protein 3 Neighboring gene proteolipid protein 2 Neighboring gene synaptophysin Neighboring gene SYP antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21687, MGC138889

General protein information

Preferred Names
PDZ domain-containing protein MAGIX
Names
PDZ domain containing, X chromosome

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099681.2NP_001093151.2  PDZ domain-containing protein MAGIX isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC231657, AI369342, AK025340, BC067800
    Consensus CDS
    CCDS48107.1
    UniProtKB/Swiss-Prot
    Q9H6Y5
    UniProtKB/TrEMBL
    A0A087WUY6
    Related
    ENSP00000479023.1, ENST00000615626.4
    Conserved Domains (1) summary
    cd00992
    Location:93130
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_001099682.2NP_001093152.2  PDZ domain-containing protein MAGIX isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC231657, AK025340, BC027995
    Consensus CDS
    CCDS75976.1
    UniProtKB/Swiss-Prot
    Q9H6Y5
    UniProtKB/TrEMBL
    A0A087X263
    Related
    ENSP00000484729.1, ENST00000614074.4
    Conserved Domains (1) summary
    cd00992
    Location:93130
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_024859.3NP_079135.3  PDZ domain-containing protein MAGIX isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC231657, AK025340, BC027995, DA072017
    Consensus CDS
    CCDS48106.1
    UniProtKB/Swiss-Prot
    Q9H6Y5
    UniProtKB/TrEMBL
    A0A075B7A2
    Related
    ENSP00000471299.1, ENST00000595224.5
    Conserved Domains (1) summary
    cd00992
    Location:124206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    49162569..49168157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543985.2XP_011542287.1  PDZ domain-containing protein MAGIX isoform X4

    See identical proteins and their annotated locations for XP_011542287.1

    UniProtKB/Swiss-Prot
    Q9H6Y5
    UniProtKB/TrEMBL
    A0A024QZ18
    Related
    ENSP00000481198.1, ENST00000616266.4
    Conserved Domains (1) summary
    cd00992
    Location:65147
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_006724560.3XP_006724623.1  PDZ domain-containing protein MAGIX isoform X1

    Conserved Domains (1) summary
    cd00992
    Location:124206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_005278062.4XP_005278119.1  PDZ domain-containing protein MAGIX isoform X2

    Conserved Domains (1) summary
    cd00992
    Location:109191
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_005278063.4XP_005278120.1  PDZ domain-containing protein MAGIX isoform X3

    Conserved Domains (1) summary
    cd00992
    Location:109191
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_011543986.2XP_011542288.1  PDZ domain-containing protein MAGIX isoform X4

    See identical proteins and their annotated locations for XP_011542288.1

    UniProtKB/Swiss-Prot
    Q9H6Y5
    UniProtKB/TrEMBL
    A0A024QZ18
    Conserved Domains (1) summary
    cd00992
    Location:65147
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_005278065.3XP_005278122.1  PDZ domain-containing protein MAGIX isoform X4

    See identical proteins and their annotated locations for XP_005278122.1

    UniProtKB/Swiss-Prot
    Q9H6Y5
    UniProtKB/TrEMBL
    A0A024QZ18
    Conserved Domains (1) summary
    cd00992
    Location:65147
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. XM_011543987.2XP_011542289.1  PDZ domain-containing protein MAGIX isoform X4

    See identical proteins and their annotated locations for XP_011542289.1

    UniProtKB/Swiss-Prot
    Q9H6Y5
    UniProtKB/TrEMBL
    A0A024QZ18
    Conserved Domains (1) summary
    cd00992
    Location:65147
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  8. XM_005278064.4XP_005278121.1  PDZ domain-containing protein MAGIX isoform X4

    See identical proteins and their annotated locations for XP_005278121.1

    UniProtKB/Swiss-Prot
    Q9H6Y5
    UniProtKB/TrEMBL
    A0A024QZ18
    Conserved Domains (1) summary
    cd00992
    Location:65147
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099680.1: Suppressed sequence

    Description
    NM_001099680.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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