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NAA60 N-alpha-acetyltransferase 60, NatF catalytic subunit [ Homo sapiens (human) ]

Gene ID: 79903, updated on 1-Jun-2020

Summary

Official Symbol
NAA60provided by HGNC
Official Full Name
N-alpha-acetyltransferase 60, NatF catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:25875
See related
Ensembl:ENSG00000122390 MIM:614246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HAT4; NatF; NAT15; hNaa60
Summary
This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in kidney (RPKM 15.2), duodenum (RPKM 14.4) and 25 other tissues See more
Orthologs

Genomic context

See NAA60 in Genome Data Viewer
Location:
16p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3443611..3486963)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3493611..3536963)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 32 Neighboring gene zinc finger protein 174 Neighboring gene zinc finger protein 597 Neighboring gene microRNA 6126 Neighboring gene chromosome 16 open reading frame 90 Neighboring gene ribosomal protein L18 pseudogene 12 Neighboring gene clusterin associated protein 1 Neighboring gene NLR family CARD domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Potential readthrough

Included gene: ZNF174

Homology

Clone Names

  • FLJ11693, FLJ14154

Gene Ontology Provided by GOA

Function Evidence Code Pubs
H4 histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide alpha-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
N-terminal peptidyl-methionine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-terminal peptidyl-methionine acetylation IDA
Inferred from Direct Assay
more info
PubMed 
N-terminal protein amino acid acetylation IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H4 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H4 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
N-alpha-acetyltransferase 60
Names
N-acetyltransferase 15 (GCN5-related, putative)
N-alpha-acetyltransferase F
epididymis secretory sperm binding protein
histone acetyltransferase type B protein 4
NP_001077069.1
NP_001077070.1
NP_001304022.1
NP_001304023.1
NP_001304024.1
NP_001304025.1
NP_001304026.1
NP_001304027.1
NP_079121.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_045230.1 RefSeqGene

    Range
    5070..48343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083600.3NP_001077069.1  N-alpha-acetyltransferase 60 isoform a

    See identical proteins and their annotated locations for NP_001077069.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AC004224, AC025283, AK130792, BC011267, BG472911, DC339939
    Consensus CDS
    CCDS45396.1
    UniProtKB/Swiss-Prot
    Q9H7X0
    Related
    ENSP00000458667.1, ENST00000575076.5
    Conserved Domains (1) summary
    pfam00583
    Location:23155
    Acetyltransf_1; Acetyltransferase (GNAT) family
  2. NM_001083601.3NP_001077070.1  N-alpha-acetyltransferase 60 isoform a

    See identical proteins and their annotated locations for NP_001077070.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. This variant may be expressed predominantly from the maternal allele (PMID:21593219). Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AC004224, AL833594, BC011267, BG472911, DC401343
    Consensus CDS
    CCDS45396.1
    UniProtKB/Swiss-Prot
    Q9H7X0
    Related
    ENSP00000385903.4, ENST00000407558.9
    Conserved Domains (1) summary
    pfam00583
    Location:23155
    Acetyltransf_1; Acetyltransferase (GNAT) family
  3. NM_001317093.1NP_001304022.1  N-alpha-acetyltransferase 60 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains multiple differences in the 5' coding region and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a longer, distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC004224, AK297219, BC011267, BG472911, DC401343
    Consensus CDS
    CCDS81937.1
    UniProtKB/Swiss-Prot
    Q9H7X0
    Related
    ENSP00000401237.2, ENST00000424546.6
    Conserved Domains (2) summary
    COG0456
    Location:44173
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:86163
    Acetyltransf_1; Acetyltransferase (GNAT) family
  4. NM_001317094.2NP_001304023.1  N-alpha-acetyltransferase 60 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter and contains multiple differences in both UTRs and in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC004224, AK311524, BC011267, DC339939
    Consensus CDS
    CCDS81940.1
    UniProtKB/Swiss-Prot
    Q9H7X0
    UniProtKB/TrEMBL
    I3L153
    Related
    ENSP00000461703.1, ENST00000576916.5
  5. NM_001317095.2NP_001304024.1  N-alpha-acetyltransferase 60 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and contains multiple differences in both UTRs and in the coding region, compared to variant 1. It initiates translation at a downstream start codon. The encoded isoform (d) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AC004224, AK092005, BC011267, BU501490
    Consensus CDS
    CCDS81941.1
    UniProtKB/Swiss-Prot
    Q9H7X0
    Related
    ENSP00000354108.5, ENST00000360862.9
    Conserved Domains (1) summary
    pfam00583
    Location:1290
    Acetyltransf_1; Acetyltransferase (GNAT) family
  6. NM_001317096.2NP_001304025.1  N-alpha-acetyltransferase 60 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents use of an alternate promoter and contains multiple differences in both UTRs and in the coding region, resulting in a frameshift, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC004224, AK298566, BC011267, BU501490, DC339939
    Consensus CDS
    CCDS81938.1
    UniProtKB/Swiss-Prot
    Q9H7X0
    Related
    ENSP00000405873.3, ENST00000421765.7
  7. NM_001317097.2NP_001304026.1  N-alpha-acetyltransferase 60 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) represents use of an alternate promoter and contains multiple differences in both UTRs and in the coding region, resulting in a frameshift, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is shorter than isoform a. Variants 8 and 9 encode the same isoform (f).
    Source sequence(s)
    AC004224, AK302361, BC011267, BU501490, DC339939
    Consensus CDS
    CCDS81939.1
    UniProtKB/Swiss-Prot
    Q9H7X0
    Related
    ENSP00000461730.1, ENST00000572942.5
  8. NM_001317098.2NP_001304027.1  N-alpha-acetyltransferase 60 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) represents use of an alternate promoter and contains multiple differences in the 5' UTR and the coding region, resulting in a frameshift, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is shorter than isoform a. Variants 8 and 9 encode the same isoform (f).
    Source sequence(s)
    AC004224, BC011267, BG472911, BG822206, DC339939
    Consensus CDS
    CCDS81939.1
    UniProtKB/Swiss-Prot
    Q9H7X0
    Related
    ENSP00000460763.1, ENST00000570819.5
  9. NM_024845.4NP_079121.1  N-alpha-acetyltransferase 60 isoform a

    See identical proteins and their annotated locations for NP_079121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter, differs in the 5' UTR, and uses an alternate splice site in the 3' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AC004224, AK024216, BC011267, BU501490, DC339939
    Consensus CDS
    CCDS45396.1
    UniProtKB/Swiss-Prot
    Q9H7X0
    Related
    ENSP00000393224.2, ENST00000414063.6
    Conserved Domains (1) summary
    pfam00583
    Location:23155
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3443611..3486963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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