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NUP85 nucleoporin 85 [ Homo sapiens (human) ]

Gene ID: 79902, updated on 3-May-2020

Summary

Official Symbol
NUP85provided by HGNC
Official Full Name
nucleoporin 85provided by HGNC
Primary source
HGNC:HGNC:8734
See related
Ensembl:ENSG00000125450 MIM:170285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nup75; FROUNT; NPHS17
Summary
This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in lymph node (RPKM 9.1), testis (RPKM 9.0) and 25 other tissues See more
Orthologs

Genomic context

See NUP85 in Genome Data Viewer
Location:
17q25.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75205436..75235759)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73201597..73231854)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985034 Neighboring gene Jupiter microtubule associated homolog 1 Neighboring gene small ubiquitin like modifier 2 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene uncharacterized LOC100287042 Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 member 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nucleoporin 85kDa (NUP85) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with Nup85 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
Vpr vpr HIV-1 Vpr-expressing HeLa cells stained with centriole markers pericentrin, gamma-tubulin, and Cen2 contain multiple pairs of centrioles scattered in the perinuclear region, indicating Vpr causes the accumulation of multiple centrosome-like structures PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12549

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
intracellular transport of virus TAS
Traceable Author Statement
more info
 
lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
macrophage chemotaxis IEA
Inferred from Electronic Annotation
more info
 
nephron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sumoylation TAS
Traceable Author Statement
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of glycolytic process TAS
Traceable Author Statement
more info
 
tRNA export from nucleus TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
host cell IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear pore outer ring IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore outer ring IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore outer ring NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear pore complex protein Nup85
Names
nucleoporin 85kDa
nucleoporin Nup75
nucleoporin Nup85

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303276.1NP_001290205.1  nuclear pore complex protein Nup85 isoform 2

    See identical proteins and their annotated locations for NP_001290205.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK297574, BM973048, DA375719, DA787201, DC424627
    UniProtKB/Swiss-Prot
    Q9BW27
    Related
    ENSP00000463382.1, ENST00000579324.5
    Conserved Domains (1) summary
    pfam07575
    Location:7560
    Nucleopor_Nup85; Nup85 Nucleoporin
  2. NM_001330472.1NP_001317401.1  nuclear pore complex protein Nup85 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC022211, BM973048
    Consensus CDS
    CCDS82202.1
    UniProtKB/TrEMBL
    J3KT10
    Related
    ENSP00000462749.1, ENST00000579298.5
  3. NM_024844.5NP_079120.1  nuclear pore complex protein Nup85 isoform 1

    See identical proteins and their annotated locations for NP_079120.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC022211, AF498261, BM973048, DA375719, DC424627
    Consensus CDS
    CCDS32730.1
    UniProtKB/Swiss-Prot
    Q9BW27
    Related
    ENSP00000245544.4, ENST00000245544.9
    Conserved Domains (1) summary
    pfam07575
    Location:53606
    Nucleopor_Nup85; Nup85 Nucleoporin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    75205436..75235759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025109.1XP_016880598.1  nuclear pore complex protein Nup85 isoform X2

  2. XM_011525267.1XP_011523569.1  nuclear pore complex protein Nup85 isoform X3

    Conserved Domains (1) summary
    pfam07575
    Location:29438
    Nucleopor_Nup85; Nup85 Nucleoporin
  3. XM_017025108.2XP_016880597.1  nuclear pore complex protein Nup85 isoform X1

  4. XM_024450951.1XP_024306719.1  nuclear pore complex protein Nup85 isoform X6

    Conserved Domains (1) summary
    pfam07575
    Location:7289
    Nucleopor_Nup85; Nup85 Nucleoporin
  5. XM_005257690.3XP_005257747.1  nuclear pore complex protein Nup85 isoform X4

    Conserved Domains (1) summary
    pfam07575
    Location:53364
    Nucleopor_Nup85; Nup85 Nucleoporin
  6. XM_011525268.2XP_011523570.1  nuclear pore complex protein Nup85 isoform X5

    Conserved Domains (1) summary
    pfam07575
    Location:53364
    Nucleopor_Nup85; Nup85 Nucleoporin
  7. XM_017025110.1XP_016880599.1  nuclear pore complex protein Nup85 isoform X3

    Conserved Domains (1) summary
    pfam07575
    Location:29438
    Nucleopor_Nup85; Nup85 Nucleoporin

RNA

  1. XR_002958072.1 RNA Sequence

  2. XR_001752629.2 RNA Sequence

  3. XR_001752628.2 RNA Sequence

  4. XR_934552.2 RNA Sequence

  5. XR_002958071.1 RNA Sequence

  6. XR_001752627.2 RNA Sequence

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