Format

Send to:

Choose Destination

PRR5L proline rich 5 like [ Homo sapiens (human) ]

Gene ID: 79899, updated on 9-Feb-2020

Summary

Official Symbol
PRR5Lprovided by HGNC
Official Full Name
proline rich 5 likeprovided by HGNC
Primary source
HGNC:HGNC:25878
See related
Ensembl:ENSG00000135362 MIM:611728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PROTOR2
Expression
Broad expression in spleen (RPKM 11.6), colon (RPKM 10.9) and 19 other tissues See more
Orthologs

Genomic context

See PRR5L in Genome Data Viewer
Location:
11p13-p12
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (36296288..36465204)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (36317725..36486754)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 3 Neighboring gene uncharacterized LOC101928510 Neighboring gene COMM domain containing 9 Neighboring gene TNF receptor associated factor 6 Neighboring gene recombination activating 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14213, FLJ22630, MGC16218

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TORC2 signaling IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TORC2 complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proline-rich protein 5-like
Names
Protein observed with Rictor-2
protor-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160167.2NP_001153639.1  proline-rich protein 5-like isoform a

    See identical proteins and their annotated locations for NP_001153639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC009656, AK055042, BX640959, DA344861, DA449593
    Consensus CDS
    CCDS31463.1
    UniProtKB/Swiss-Prot
    Q6MZQ0
    UniProtKB/TrEMBL
    B3KNU3
    Related
    ENSP00000435050.1, ENST00000530639.6
    Conserved Domains (1) summary
    pfam08539
    Location:49168
    HbrB; HbrB-like
  2. NM_001160168.1NP_001153640.1  proline-rich protein 5-like isoform b

    See identical proteins and their annotated locations for NP_001153640.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate AUG and a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AC009656, AK024275, BX640959, DA458327
    UniProtKB/Swiss-Prot
    Q6MZQ0
    Conserved Domains (1) summary
    pfam08539
    Location:5100
    HbrB; HbrB-like
  3. NM_001160169.1NP_001153641.1  proline-rich protein 5-like isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC009656, BC008922, BX640959, DA344861, DR001466
    Consensus CDS
    CCDS53617.1
    UniProtKB/Swiss-Prot
    Q6MZQ0
    Related
    ENSP00000435241.1, ENST00000527487.1
    Conserved Domains (1) summary
    pfam08539
    Location:49168
    HbrB; HbrB-like
  4. NM_024841.4NP_079117.3  proline-rich protein 5-like isoform a

    See identical proteins and their annotated locations for NP_079117.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC009656, BX640959, DA344861, DA458327
    Consensus CDS
    CCDS31463.1
    UniProtKB/Swiss-Prot
    Q6MZQ0
    Related
    ENSP00000368144.3, ENST00000378867.7
    Conserved Domains (1) summary
    pfam08539
    Location:49168
    HbrB; HbrB-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    36296288..36465204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center