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ZNF613 zinc finger protein 613 [ Homo sapiens (human) ]

Gene ID: 79898, updated on 13-May-2022

Summary

Official Symbol
ZNF613provided by HGNC
Official Full Name
zinc finger protein 613provided by HGNC
Primary source
HGNC:HGNC:25827
See related
Ensembl:ENSG00000176024 AllianceGenome:HGNC:25827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in prostate (RPKM 6.4), placenta (RPKM 2.1) and 22 other tissues See more
Orthologs
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Genomic context

See ZNF613 in Genome Data Viewer
Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51927472..51946621)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55014667..55033819)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52430725..52449874)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF649 antisense RNA 1 Neighboring gene zinc finger protein 649 Neighboring gene zinc finger protein 41 pseudogene Neighboring gene ZNF350 antisense RNA 1 Neighboring gene zinc finger protein 350 Neighboring gene zinc finger protein 615

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13590

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031721.4NP_001026891.2  zinc finger protein 613 isoform 1

    See identical proteins and their annotated locations for NP_001026891.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011460, AK027565, BC057776, CA427456
    Consensus CDS
    CCDS33089.1
    UniProtKB/Swiss-Prot
    Q6PF04
    Related
    ENSP00000293471.5, ENST00000293471.11
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:176531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:374394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:484506
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:414439
    zf-H2C2_2; Zinc-finger double domain
  2. NM_024840.4NP_079116.2  zinc finger protein 613 isoform 2

    See identical proteins and their annotated locations for NP_079116.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC011460, AK027565, CA427456
    Consensus CDS
    CCDS12844.1
    UniProtKB/Swiss-Prot
    Q6PF04
    Related
    ENSP00000375671.3, ENST00000391794.8
    Conserved Domains (5) summary
    smart00349
    Location:131
    KRAB; krueppel associated box
    COG5048
    Location:140495
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:338358
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:448470
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:378403
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51927472..51946621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55014667..55033819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)