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RPP21 ribonuclease P/MRP subunit p21 [ Homo sapiens (human) ]

Gene ID: 79897, updated on 23-Sep-2018

Summary

Official Symbol
RPP21provided by HGNC
Official Full Name
ribonuclease P/MRP subunit p21provided by HGNC
Primary source
HGNC:HGNC:21300
See related
Ensembl:ENSG00000241370 MIM:612524; Vega:OTTHUMG00000031220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAT60; C6orf135
Summary
RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]
Expression
Ubiquitous expression in endometrium (RPKM 10.7), ovary (RPKM 10.6) and 25 other tissues See more
Orthologs

Genomic context

See RPP21 in Genome Data Viewer
Location:
6p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (30345129..30346858)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30312897..30314635)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene HLA complex group 17 Neighboring gene major histocompatibility complex, class I, L (pseudogene) Neighboring gene HLA complex group 18 Neighboring gene TRIM39-RPP21 readthrough Neighboring gene tripartite motif containing 39 Neighboring gene major histocompatibility complex, class I, N (pseudogene) Neighboring gene ubiquilin 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystem (from REACTOME)
    Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • rRNA processing, organism-specific biosystem (from REACTOME)
    rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
  • rRNA processing in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
    rRNA processing in the nucleus and cytosol, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
  • tRNA processing, organism-specific biosystem (from REACTOME)
    tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
  • tRNA processing in the nucleus, organism-specific biosystem (from REACTOME)
    tRNA processing in the nucleus, organism-specific biosystemGenes encoding transfer RNAs are transcribed in the nucleus by RNA polymerase III. (Distinct processes of transcription and processing also occur in mitochondria.) The initial transcripts, pre-tRNAs,...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TRIM39-RPP21

Readthrough gene: TRIM39-RPP21, Included gene: TRIM39

Homology

Clone Names

  • FLJ22638

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
tRNA 5'-leader removal IDA
Inferred from Direct Assay
more info
PubMed 
tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
multimeric ribonuclease P complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolar ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ribonuclease P protein subunit p21
Names
RNaseP protein p21
ribonuclease P/MRP 21kDa subunit
ribonucleoprotein V
NP_001186049.1
NP_001186050.1
NP_079115.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199120.1NP_001186049.1  ribonuclease P protein subunit p21 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ504713, BG708140, BI598757, DA270919
    Consensus CDS
    CCDS56409.1
    UniProtKB/Swiss-Prot
    Q9H633
    UniProtKB/TrEMBL
    A0A1U9X8H3
    Related
    ENSP00000409799.2, OTTHUMP00000163580, ENST00000433076.6, OTTHUMT00000256040
    Conserved Domains (1) summary
    pfam04032
    Location:13103
    Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain
  2. NM_001199121.1NP_001186050.1  ribonuclease P protein subunit p21 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, and an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AJ504716, BG708140, DA270919
    Consensus CDS
    CCDS56410.1
    UniProtKB/Swiss-Prot
    Q9H633
    Related
    ENSP00000397778.2, OTTHUMP00000163581, ENST00000436442.2, OTTHUMT00000076452
    Conserved Domains (1) summary
    pfam04032
    Location:1396
    Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain
  3. NM_024839.2NP_079115.1  ribonuclease P protein subunit p21 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AJ504713, BG708140, DA270919
    Consensus CDS
    CCDS4679.1
    UniProtKB/Swiss-Prot
    Q9H633
    Related
    ENSP00000403833.2, OTTHUMP00000029321, ENST00000442966.6, OTTHUMT00000076451
    Conserved Domains (1) summary
    pfam04032
    Location:1396
    Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    30345129..30346858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    1674625..1676354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    1824810..1826539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p12 ALT_REF_LOCI_3

    Range
    1600975..1602704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p12 ALT_REF_LOCI_4

    Range
    1655361..1657092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p12 ALT_REF_LOCI_6

    Range
    1600211..1601940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p12 ALT_REF_LOCI_7

    Range
    1643586..1645315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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