Format

Send to:

Choose Destination

THNSL1 threonine synthase like 1 [ Homo sapiens (human) ]

Gene ID: 79896, updated on 7-Jul-2019

Summary

Official Symbol
THNSL1provided by HGNC
Official Full Name
threonine synthase like 1provided by HGNC
Primary source
HGNC:HGNC:26160
See related
Ensembl:ENSG00000185875 MIM:611260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSH1
Expression
Ubiquitous expression in liver (RPKM 5.2), thyroid (RPKM 5.2) and 24 other tissues See more
Orthologs

Genomic context

See THNSL1 in Genome Data Viewer
Location:
10p12.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (24952319..25026664)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (25305508..25315593)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene phosphoribosyl transferase domain containing 1 Neighboring gene NFE2L2 motif-containing MPRA enhancer 245 Neighboring gene RN7SK pseudogene 241 Neighboring gene Sharpr-MPRA regulatory region 97 Neighboring gene enkurin, TRPC channel interacting protein Neighboring gene long intergenic non-protein coding RNA 1516 Neighboring gene GPR158 antisense RNA 1 Neighboring gene G protein-coupled receptor 158 Neighboring gene RN7SK pseudogene 220

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024838.5NP_079114.3  threonine synthase-like 1

    See identical proteins and their annotated locations for NP_079114.3

    Status: VALIDATED

    Source sequence(s)
    AK025655, AK125249, BX647989, DA496769
    Consensus CDS
    CCDS7147.1
    UniProtKB/Swiss-Prot
    Q8IYQ7
    UniProtKB/TrEMBL
    Q9H6P9
    Related
    ENSP00000365534.4, ENST00000376356.5
    Conserved Domains (5) summary
    cd01560
    Location:230733
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    PRK00131
    Location:56223
    aroK; shikimate kinase; Reviewed
    PRK09225
    Location:231739
    PRK09225; threonine synthase; Validated
    cd00464
    Location:57211
    SK; Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis ...
    cl21455
    Location:1478
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    24952319..25026664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016665.1XP_016872154.1  threonine synthase-like 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8IYQ7
    Conserved Domains (5) summary
    cd01560
    Location:230733
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    PRK00131
    Location:56223
    aroK; shikimate kinase; Reviewed
    PRK09225
    Location:231739
    PRK09225; threonine synthase; Validated
    cd00464
    Location:57211
    SK; Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis ...
    cl21455
    Location:1478
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_005252597.3XP_005252654.1  threonine synthase-like 1 isoform X1

    See identical proteins and their annotated locations for XP_005252654.1

    UniProtKB/Swiss-Prot
    Q8IYQ7
    Related
    ENSP00000434887.1, ENST00000524413.5
    Conserved Domains (5) summary
    cd01560
    Location:230733
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    PRK00131
    Location:56223
    aroK; shikimate kinase; Reviewed
    PRK09225
    Location:231739
    PRK09225; threonine synthase; Validated
    cd00464
    Location:57211
    SK; Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis ...
    cl21455
    Location:1478
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Support Center