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GGNBP2 gametogenetin binding protein 2 [ Homo sapiens (human) ]

Gene ID: 79893, updated on 3-May-2025
Official Symbol
GGNBP2provided by HGNC
Official Full Name
gametogenetin binding protein 2provided by HGNC
Primary source
HGNC:HGNC:19357
See related
Ensembl:ENSG00000278311 MIM:612275; AllianceGenome:HGNC:19357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIF3; LZK1; DIF-3; LCRG1; ZFP403; ZNF403
Summary
Predicted to be involved in spermatogenesis. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of cell population proliferation; and negative regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in testis (RPKM 42.4), bone marrow (RPKM 29.3) and 25 other tissues See more
Orthologs
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See GGNBP2 in Genome Data Viewer
Location:
17q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (36544919..36589848)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (37530672..37576192)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34900768..34946278)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 439 Neighboring gene zinc finger HIT-type containing 3 Neighboring gene myosin XIX Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:34889386-34890061 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class W Neighboring gene ribosomal protein S2 pseudogene 50 Neighboring gene uncharacterized LOC107985031 Neighboring gene dehydrogenase/reductase 11 Neighboring gene mitochondrial rRNA methyltransferase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34983260-34983760

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930. Li Y, et al. Cancer Lett, 2004 Jun 8. PMID 15145523
  2. Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators. Guan R, et al. Mol Cell Biochem, 2012 Jun. PMID 22350815
  3. Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells. Xu X, et al. Oncol Rep, 2020 Dec. PMID 33125130, Free PMC Article
  4. Effects of gametogenetin-binding protein 2 on proliferation, invasion and migration of prostate cancer PC-3 cells. Yang Z, et al. Andrologia, 2020 Mar. PMID 31797427
  5. ZFP403, a novel tumor suppressor, inhibits the proliferation and metastasis in ovarian cancer. Zhu Z, et al. Gynecol Oncol, 2017 Nov. PMID 28864131

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells.
    Title: Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells.
  2. Effects of gametogenetin-binding protein 2 on proliferation, invasion and migration of prostate cancer PC-3 cells.
    Title: Effects of gametogenetin-binding protein 2 on proliferation, invasion and migration of prostate cancer PC-3 cells.
  3. Our data demonstrate that GGNBP2 suppresses cancer aggressiveness by inhibition of IL-6/STAT3 activation in triple-negative breast cancer
    Title: GGNBP2 suppresses triple-negative breast cancer aggressiveness through inhibition of IL-6/STAT3 signaling activation.
  4. Results identified GGNBP2 as a novel tumor suppressor which is downregulated in human breast tumors and cell lines and suggest that GGNBP2 may function as a corepressor to inhibit ERa's transcriptional activity and consequently inhibit tumorigenic potential of breast cancer cells.
    Title: GGNBP2 acts as a tumor suppressor by inhibiting estrogen receptor α activity in breast cancer cells.
  5. The effects of ZFP403 on cell proliferation and metastasis suggest that it may serve as a tumor suppressor in ovarian cancer.
    Title: ZFP403, a novel tumor suppressor, inhibits the proliferation and metastasis in ovarian cancer.
  6. Results show that downregulation of RNASET2 and GGNBP2 in drug-resistant ovarian cancer tissues/cells contributes to the regulation of drug resistance in ovarian cancer.
    Title: Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer.
  7. There is an essential role for ZNF403 in cell proliferation and G2/M cell-cycle transition.
    Title: Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators.
  8. LCRG1 is a novel gene localized to the tumor suppressor locus D17S800-D17S930 involved in laryngeal carcinoma.
    Title: Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ21230, FLJ22561, FLJ42090

Gene Ontology Provided by GOA

Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within labyrinthine layer development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of receptor signaling pathway via STAT IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
gametogenetin-binding protein 2
Names
C3HC4-type zinc finger protein
laryngeal carcinoma related gene 1
laryngeal carcinoma-related protein 1
zinc finger protein 403

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024835.5 → NP_079111.1  gametogenetin-binding protein 2

    See identical proteins and their annotated locations for NP_079111.1

    Status: VALIDATED

    Source sequence(s)
    AF126964, BC137491, DA494492
    Consensus CDS
    CCDS11314.1
    UniProtKB/Swiss-Prot
    B2RPK7, Q96T90, Q9GZR8, Q9H3C7, Q9H767
    UniProtKB/TrEMBL
    A8K3S2
    Related
    ENSP00000478220.1, ENST00000613102.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    36544919..36589848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257689.4 → XP_005257746.1  gametogenetin-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005257746.1

    UniProtKB/TrEMBL
    A8K3S2

  2. XM_011525266.3 → XP_011523568.1  gametogenetin-binding protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011523568.1

    UniProtKB/TrEMBL
    A8K3S2

  3. XM_047436774.1 → XP_047292730.1  gametogenetin-binding protein 2 isoform X5

    UniProtKB/TrEMBL
    A8K3S2

  4. XM_011525265.4 → XP_011523567.1  gametogenetin-binding protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011523567.1

    UniProtKB/TrEMBL
    A8K3S2

  5. XM_017025107.2 → XP_016880596.1  gametogenetin-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A8K3S2

  6. XM_047436775.1 → XP_047292731.1  gametogenetin-binding protein 2 isoform X6

    UniProtKB/TrEMBL
    A8K3S2

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    779823..825343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329335.1 → XP_054185310.1  gametogenetin-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A8K3S2

  2. XM_054329338.1 → XP_054185313.1  gametogenetin-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    A8K3S2

  3. XM_054329339.1 → XP_054185314.1  gametogenetin-binding protein 2 isoform X5

    UniProtKB/TrEMBL
    A8K3S2

  4. XM_054329336.1 → XP_054185311.1  gametogenetin-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A8K3S2

  5. XM_054329337.1 → XP_054185312.1  gametogenetin-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A8K3S2

  6. XM_054329340.1 → XP_054185315.1  gametogenetin-binding protein 2 isoform X6

    UniProtKB/TrEMBL
    A8K3S2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    37530672..37576192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317271.1 → XP_054173246.1  gametogenetin-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A8K3S2

  2. XM_054317274.1 → XP_054173249.1  gametogenetin-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    A8K3S2

  3. XM_054317275.1 → XP_054173250.1  gametogenetin-binding protein 2 isoform X5

    UniProtKB/TrEMBL
    A8K3S2

  4. XM_054317272.1 → XP_054173247.1  gametogenetin-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A8K3S2

  5. XM_054317273.1 → XP_054173248.1  gametogenetin-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A8K3S2

  6. XM_054317276.1 → XP_054173251.1  gametogenetin-binding protein 2 isoform X6

    UniProtKB/TrEMBL
    A8K3S2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H3C7.1 GenPept UniProtKB/Swiss-Prot:Q9H3C7

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