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MCMBP minichromosome maintenance complex binding protein [ Homo sapiens (human) ]

Gene ID: 79892, updated on 7-Jul-2019

Summary

Official Symbol
MCMBPprovided by HGNC
Official Full Name
minichromosome maintenance complex binding proteinprovided by HGNC
Primary source
HGNC:HGNC:25782
See related
Ensembl:ENSG00000197771 MIM:610909
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCM-BP; C10orf119
Summary
This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in placenta (RPKM 15.0), appendix (RPKM 14.1) and 25 other tissues See more
Orthologs

Genomic context

See MCMBP in Genome Data Viewer
Location:
10q26.11
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (119829404..119873628, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121588916..121633140, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase F Neighboring gene RNA, 7SL, cytoplasmic 846, pseudogene Neighboring gene uncharacterized LOC105378513 Neighboring gene phosphatase and actin regulator 2 pseudogene 1 Neighboring gene SEC23 interacting protein Neighboring gene microRNA 4682

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13081, FLJ36756

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA-dependent DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-dependent DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with MCM complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mini-chromosome maintenance complex-binding protein
Names
MCM-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256378.1NP_001243307.1  mini-chromosome maintenance complex-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001243307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AC027672, BC004183
    Consensus CDS
    CCDS58099.1
    UniProtKB/Swiss-Prot
    Q9BTE3
    UniProtKB/TrEMBL
    A0A0S2Z5P5
    Related
    ENSP00000358073.3, ENST00000369077.3
    Conserved Domains (1) summary
    pfam09739
    Location:36626
    MCM_bind; Mini-chromosome maintenance replisome factor
  2. NM_001256379.1NP_001243308.1  mini-chromosome maintenance complex-binding protein isoform 3

    See identical proteins and their annotated locations for NP_001243308.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region, and uses a downstream start codon compared to variant 1. The resulting protein (isoform 3) is shorter and has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC027672, AK094075, DA381502
    UniProtKB/Swiss-Prot
    Q9BTE3
    Conserved Domains (1) summary
    pfam09739
    Location:1453
    MCM_bind; Mini-chromosome maintenance replisome factor
  3. NM_024834.3NP_079110.1  mini-chromosome maintenance complex-binding protein isoform 1

    See identical proteins and their annotated locations for NP_079110.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AA292620, AC027672, AK023143, BQ929053
    Consensus CDS
    CCDS7617.1
    UniProtKB/Swiss-Prot
    Q9BTE3
    Related
    ENSP00000353098.3, ENST00000360003.7
    Conserved Domains (1) summary
    pfam09739
    Location:36628
    MCM_bind; Mini-chromosome maintenance replisome factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    119829404..119873628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016664.1XP_016872153.1  mini-chromosome maintenance complex-binding protein isoform X4

  2. XM_011540170.1XP_011538472.1  mini-chromosome maintenance complex-binding protein isoform X3

    Conserved Domains (1) summary
    pfam09739
    Location:1558
    MCM_bind; Mini-chromosome maintenance replisome factor
  3. XM_017016663.1XP_016872152.1  mini-chromosome maintenance complex-binding protein isoform X2

  4. XM_005270157.4XP_005270214.1  mini-chromosome maintenance complex-binding protein isoform X1

    Conserved Domains (1) summary
    pfam09739
    Location:36573
    MCM_bind; Mini-chromosome maintenance replisome factor
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