U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PLBD1 phospholipase B domain containing 1 [ Homo sapiens (human) ]

Gene ID: 79887, updated on 17-Jun-2024

Summary

Official Symbol
PLBD1provided by HGNC
Official Full Name
phospholipase B domain containing 1provided by HGNC
Primary source
HGNC:HGNC:26215
See related
Ensembl:ENSG00000121316 MIM:618486; AllianceGenome:HGNC:26215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 104.6), colon (RPKM 35.9) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PLBD1 in Genome Data Viewer
Location:
12p13.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (14503661..14567883, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (14381172..14445388, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (14656595..14720817, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902884 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:14518197-14519014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6046 Neighboring gene ribosomal protein L30 pseudogene 11 Neighboring gene Sharpr-MPRA regulatory region 5402 Neighboring gene activating transcription factor 7 interacting protein Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:14658416-14659615 Neighboring gene uncharacterized LOC101928317 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:14719662-14719838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:14720083-14720764 Neighboring gene RN7SK pseudogene 134 Neighboring gene PLBD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6050 Neighboring gene guanylate cyclase 2C Neighboring gene GUCY2C antisense RNA 1 Neighboring gene MPRA-validated peak1579 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:14857936-14858468 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:14858469-14859000 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:14862728-14863259 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:14863260-14863792 Neighboring gene Sharpr-MPRA regulatory region 453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6051 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:14881606-14881786 Neighboring gene uncharacterized LOC105369669 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:14922691-14923286 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:14923287-14923883

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of phospholipase B domain containing 1 (PLBD1) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ22662

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in phospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phospholipase B-like 1
Names
LAMA-like protein 1
PLB homolog 1
lamina ancestor homolog 1
phospholipase B domain-containing protein 1
putative phospholipase B-like 1
NP_079105.4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024829.6NP_079105.4  phospholipase B-like 1 precursor

    See identical proteins and their annotated locations for NP_079105.4

    Status: VALIDATED

    Source sequence(s)
    AC008114
    Consensus CDS
    CCDS31751.1
    UniProtKB/Swiss-Prot
    A8K4E9, Q6P4A8, Q9BVV3, Q9H625
    Related
    ENSP00000240617.5, ENST00000240617.10
    Conserved Domains (1) summary
    pfam04916
    Location:32544
    Phospholip_B; Phospholipase B

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    14503661..14567883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    14381172..14445388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)