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PLBD1 phospholipase B domain containing 1 [ Homo sapiens (human) ]

Gene ID: 79887, updated on 5-Aug-2018

Summary

Official Symbol
PLBD1provided by HGNC
Official Full Name
phospholipase B domain containing 1provided by HGNC
Primary source
HGNC:HGNC:26215
See related
Ensembl:ENSG00000121316 Vega:OTTHUMG00000168821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in bone marrow (RPKM 104.6), colon (RPKM 35.9) and 17 other tissues See more
Orthologs

Genomic context

See PLBD1 in Genome Data Viewer
Location:
12p13.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (14503663..14567857, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (14656597..14720791, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L30 pseudogene 11 Neighboring gene activating transcription factor 7 interacting protein Neighboring gene uncharacterized LOC101928317 Neighboring gene RNA, 7SK small nuclear pseudogene 134 Neighboring gene PLBD1 antisense RNA 1 Neighboring gene chromosome 12 open reading frame 60 Neighboring gene guanylate cyclase 2C Neighboring gene uncharacterized LOC105369669

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of phospholipase B domain containing 1 (PLBD1) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Acyl chain remodelling of PC, organism-specific biosystem (from REACTOME)
    Acyl chain remodelling of PC, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylcholine (PC) is hydrolysed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid compos...
  • Acyl chain remodelling of PE, organism-specific biosystem (from REACTOME)
    Acyl chain remodelling of PE, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylethanolamine (PE) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid ...
  • Acyl chain remodelling of PI, organism-specific biosystem (from REACTOME)
    Acyl chain remodelling of PI, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylinositol (PI) is hydrolyzed by phospholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid comp...
  • Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
    Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
  • Hydrolysis of LPC, organism-specific biosystem (from REACTOME)
    Hydrolysis of LPC, organism-specific biosystemLysophosphatidylcholine (LPC) is hydrolyzed by phospholipases to produce glycerophosphocholine (GPCho) which is in turn hydrolyzed by glycerophosphocholine phosphodiesterase to produce choline (Cho) ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
    Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22662

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lysophospholipase activity TAS
Traceable Author Statement
more info
 
phospholipase A2 activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylinositol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phospholipase B-like 1
Names
LAMA-like protein 1
PLB homolog 1
lamina ancestor homolog 1
phospholipase B domain-containing protein 1
putative phospholipase B-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024829.5NP_079105.4  phospholipase B-like 1 precursor

    See identical proteins and their annotated locations for NP_079105.4

    Status: VALIDATED

    Source sequence(s)
    AI370813, AK026315, BC063561, BQ721063, BU859334
    Consensus CDS
    CCDS31751.1
    UniProtKB/Swiss-Prot
    Q6P4A8
    Related
    ENSP00000240617.5, OTTHUMP00000239536, ENST00000240617.9, OTTHUMT00000401203
    Conserved Domains (1) summary
    pfam04916
    Location:32544
    Phospholip_B; Phospholipase B

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    14503663..14567857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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