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PLBD1 phospholipase B domain containing 1 [ Homo sapiens (human) ]

Gene ID: 79887, updated on 3-May-2025
Official Symbol
PLBD1provided by HGNC
Official Full Name
phospholipase B domain containing 1provided by HGNC
Primary source
HGNC:HGNC:26215
See related
Ensembl:ENSG00000121316 MIM:618486; AllianceGenome:HGNC:26215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Located in extracellular space. [provided by Alliance of Genome Resources, May 2025]
Expression
Broad expression in bone marrow (RPKM 104.6), colon (RPKM 35.9) and 17 other tissues See more
Orthologs
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See PLBD1 in Genome Data Viewer
Location:
12p13.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (14503661..14567883, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (14381172..14445388, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (14656595..14720817, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902884 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:14518197-14519014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6046 Neighboring gene ribosomal protein L30 pseudogene 11 Neighboring gene Sharpr-MPRA regulatory region 5402 Neighboring gene activating transcription factor 7 interacting protein Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:14658416-14659615 Neighboring gene PLBD1 antisense RNA 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:14719662-14719838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:14720083-14720764 Neighboring gene RN7SK pseudogene 134 Neighboring gene PLBD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6050 Neighboring gene guanylate cyclase 2C Neighboring gene GUCY2C antisense RNA 1 Neighboring gene MPRA-validated peak1579 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:14857936-14858468 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:14858469-14859000 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:14862728-14863259 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:14863260-14863792 Neighboring gene Sharpr-MPRA regulatory region 453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6051 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:14881606-14881786 Neighboring gene uncharacterized LOC105369669 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:14922691-14923286 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:14923287-14923883

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

EBI GWAS Catalog

Description
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of phospholipase B domain containing 1 (PLBD1) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ22662

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
phospholipase B-like 1
Names
LAMA-like protein 1
PLB homolog 1
lamina ancestor homolog 1
phospholipase B domain-containing protein 1
putative phospholipase B-like 1
NP_079105.4

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024829.6NP_079105.4  phospholipase B-like 1 precursor

    See identical proteins and their annotated locations for NP_079105.4

    Status: VALIDATED

    Source sequence(s)
    AC008114
    Consensus CDS
    CCDS31751.1
    UniProtKB/Swiss-Prot
    A8K4E9, Q6P4A8, Q9BVV3, Q9H625
    Related
    ENSP00000240617.5, ENST00000240617.10
    Conserved Domains (1) summary
    pfam04916
    Location:32544
    Phospholip_B; Phospholipase B

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    14503661..14567883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    14381172..14445388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)