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gpx3 glutathione peroxidase 3 [ Danio rerio (zebrafish) ]

Gene ID: 798788, updated on 19-Jun-2024

Summary

Official Symbol
gpx3provided by ZNC
Official Full Name
glutathione peroxidase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-070222-3
See related
Ensembl:ENSDARG00000043342 AllianceGenome:ZFIN:ZDB-GENE-070222-3
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. This is one of the glutathione-related genes that is involved in redox regulation during embryonic development. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2016]
Orthologs
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Genomic context

See gpx3 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (49444339..49460399, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (50456582..50472642, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene annexin A6 Neighboring gene uncharacterized LOC103908781 Neighboring gene TNFAIP3 interacting protein 1 Neighboring gene dynactin 4 Neighboring gene synaptopodin

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within swimming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutathione peroxidase 3
Names
glutathione peroxidase 3 (plasma)
NP_001131027.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137555.3NP_001131027.1  glutathione peroxidase 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL914419, CO926849, CT997810, EB936689
    UniProtKB/TrEMBL
    A0A8M1NIR5
    Related
    ENSDARP00000063624.5, ENSDART00000063625.6
    Conserved Domains (1) summary
    cd00340
    Location:37210
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    49444339..49460399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)