rnasel3 ribonuclease like 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rnasel3provided by ZNC
Official Full Name: ribonuclease like 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-050809-5
See related: Ensembl:ENSDARG00000036171 AllianceGenome:ZFIN:ZDB-GENE-050809-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6907218
Summary: Enables RNA nuclease activity. Acts upstream of or within defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Predicted to be located in extracellular region. Is expressed in digestive system; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to human ANG (angiogenin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (38654305..38656046)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (38313991..38315732)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb95a10.x1 (e-PCR)
- UniSTS:191860

fb95a10.x1 (e-PCR)
- UniSTS:191861

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IC Inferred by Curator more info	PubMed
enables RNA endonuclease activity, producing 3'-phosphomonoesters	IEA Inferred from Electronic Annotation more info
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribonuclease-like 3

Names: Dr-RNase1; RNase 1

NP_001092923.1

EC 3.1.27.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099453.1 → NP_001092923.1 ribonuclease-like 3 precursor

See identical proteins and their annotated locations for NP_001092923.1

Status: PROVISIONAL

Source sequence(s)

EF382669

UniProtKB/Swiss-Prot

A5HAK0

Related

ENSDARP00000123763.1, ENSDART00000148938.4

Conserved Domains (1) summary

cd06265
Location:29 → 145

RNase_A_canonical; Canonical RNase A family includes all vertebrate homologues to the bovine pancreatic ribonuclease A (RNase A) that contain the catalytic site, necessary for RNase activity. In the human genome 8 RNases , refered to as "canonical" RNases, have been ...