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DCAKD dephospho-CoA kinase domain containing [ Homo sapiens (human) ]

Gene ID: 79877, updated on 1-Jun-2020

Summary

Official Symbol
DCAKDprovided by HGNC
Official Full Name
dephospho-CoA kinase domain containingprovided by HGNC
Primary source
HGNC:HGNC:26238
See related
Ensembl:ENSG00000172992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 10.9), thyroid (RPKM 9.8) and 25 other tissues See more
Orthologs

Genomic context

See DCAKD in Genome Data Viewer
Location:
17q21.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (45023338..45061131, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43100706..43138473, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene basic proline-rich protein-like Neighboring gene uncharacterized LOC107987243 Neighboring gene N-myristoyltransferase 1 Neighboring gene phospholipase C delta 3 Neighboring gene microRNA 6784

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22955

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
dephospho-CoA kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
membrane HDA PubMed 

General protein information

Preferred Names
dephospho-CoA kinase domain-containing protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128631.3NP_001122103.1  dephospho-CoA kinase domain-containing protein

    See identical proteins and their annotated locations for NP_001122103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC015936, AC116493
    Consensus CDS
    CCDS11493.1
    UniProtKB/Swiss-Prot
    Q8WVC6
    Related
    ENSP00000467913.1, ENST00000588499.5
    Conserved Domains (1) summary
    PRK00081
    Location:1196
    coaE; dephospho-CoA kinase; Reviewed
  2. NM_001288654.2NP_001275583.1  dephospho-CoA kinase domain-containing protein

    See identical proteins and their annotated locations for NP_001275583.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC015936, AI497945, BC018132, BF115235, BX487139, HY061203
    Consensus CDS
    CCDS11493.1
    UniProtKB/Swiss-Prot
    Q8WVC6
    Related
    ENSP00000308515.5, ENST00000310604.8
    Conserved Domains (1) summary
    PRK00081
    Location:1196
    coaE; dephospho-CoA kinase; Reviewed
  3. NM_001288655.2NP_001275584.1  dephospho-CoA kinase domain-containing protein

    See identical proteins and their annotated locations for NP_001275584.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC015936, AC116493
    Consensus CDS
    CCDS11493.1
    UniProtKB/Swiss-Prot
    Q8WVC6
    Related
    ENSP00000498268.1, ENST00000651974.1
    Conserved Domains (1) summary
    PRK00081
    Location:1196
    coaE; dephospho-CoA kinase; Reviewed
  4. NM_001321326.2NP_001308255.1  dephospho-CoA kinase domain-containing protein

    Status: VALIDATED

    Source sequence(s)
    AC015936, AC116493
    Consensus CDS
    CCDS11493.1
    UniProtKB/Swiss-Prot
    Q8WVC6
    Related
    ENSP00000413483.1, ENST00000452796.6
    Conserved Domains (1) summary
    PRK00081
    Location:1196
    coaE; dephospho-CoA kinase; Reviewed
  5. NM_024819.7NP_079095.3  dephospho-CoA kinase domain-containing protein

    See identical proteins and their annotated locations for NP_079095.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC015936, AC116493
    Consensus CDS
    CCDS11493.1
    UniProtKB/Swiss-Prot
    Q8WVC6
    Related
    ENSP00000341504.4, ENST00000342350.9
    Conserved Domains (1) summary
    PRK00081
    Location:1196
    coaE; dephospho-CoA kinase; Reviewed

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    45023338..45061131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025105.1XP_016880594.1  dephospho-CoA kinase domain-containing protein isoform X3

  2. XM_011525262.2XP_011523564.1  dephospho-CoA kinase domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011523564.1

    UniProtKB/Swiss-Prot
    Q8WVC6
    Conserved Domains (1) summary
    PRK00081
    Location:1196
    coaE; dephospho-CoA kinase; Reviewed
  3. XM_017025104.1XP_016880593.1  dephospho-CoA kinase domain-containing protein isoform X2

    UniProtKB/Swiss-Prot
    Q8WVC6
    Conserved Domains (2) summary
    COG0237
    Location:1107
    CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
    cl17190
    Location:198
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  4. XM_017025103.1XP_016880592.1  dephospho-CoA kinase domain-containing protein isoform X2

    UniProtKB/Swiss-Prot
    Q8WVC6
    Conserved Domains (2) summary
    COG0237
    Location:1107
    CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
    cl17190
    Location:198
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  5. XM_005257688.2XP_005257745.1  dephospho-CoA kinase domain-containing protein isoform X2

    See identical proteins and their annotated locations for XP_005257745.1

    UniProtKB/Swiss-Prot
    Q8WVC6
    Related
    ENST00000588295.1
    Conserved Domains (2) summary
    COG0237
    Location:1107
    CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
    cl17190
    Location:198
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RNA

  1. XR_002958070.1 RNA Sequence

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