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NUDT18 nudix hydrolase 18 [ Homo sapiens (human) ]

Gene ID: 79873, updated on 2-Mar-2021

Summary

Official Symbol
NUDT18provided by HGNC
Official Full Name
nudix hydrolase 18provided by HGNC
Primary source
HGNC:HGNC:26194
See related
Ensembl:ENSG00000275074 MIM:615791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTH3
Summary
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]
Expression
Ubiquitous expression in spleen (RPKM 3.1), lymph node (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See NUDT18 in Genome Data Viewer
Location:
8p21.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (22106872..22110355, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (21964389..21966932, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs781 Neighboring gene dematin actin binding protein Neighboring gene FHF complex subunit HOOK interacting protein 2B Neighboring gene HR lysine demethylase and nuclear receptor corepressor Neighboring gene receptor accessory protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22494

Gene Ontology Provided by GOA

Function Evidence Code Pubs
8-hydroxy-dADP phosphatase activity EXP
Inferred from Experiment
more info
PubMed 
8-hydroxy-dADP phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
8-oxo-GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
8-oxo-GDP phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
8-oxo-dGDP phosphatase activity EXP
Inferred from Experiment
more info
PubMed 
8-oxo-dGDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
8-oxo-dGDP phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
GDP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
dADP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
dGDP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
nucleobase-containing small molecule catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
8-oxo-dGDP phosphatase NUDT18
Names
2-hydroxy-dADP phosphatase
7,8-dihydro-8-oxoguanine phosphatase
mutT homolog 3
mutT human homolog 3
nucleoside diphosphate-linked moiety X motif 18
nudix (nucleoside diphosphate linked moiety X)-type motif 18
nudix motif 18
NP_079091.3
XP_011542952.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032941.1 RefSeqGene

    Range
    5001..7542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024815.4NP_079091.3  8-oxo-dGDP phosphatase NUDT18

    See identical proteins and their annotated locations for NP_079091.3

    Status: REVIEWED

    Source sequence(s)
    AC091171, BC016902, DA015404
    Consensus CDS
    CCDS75706.1
    UniProtKB/Swiss-Prot
    Q6ZVK8
    Related
    ENSP00000480722.1, ENST00000611621.2
    Conserved Domains (1) summary
    cd04671
    Location:44166
    Nudix_Hydrolase_13; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    22106872..22110355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544650.1XP_011542952.1  8-oxo-dGDP phosphatase NUDT18 isoform X1

    Conserved Domains (1) summary
    cd04671
    Location:260382
    Nudix_Hydrolase_13; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
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