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SNX22 sorting nexin 22 [ Homo sapiens (human) ]

Gene ID: 79856, updated on 7-Jun-2020

Summary

Official Symbol
SNX22provided by HGNC
Official Full Name
sorting nexin 22provided by HGNC
Primary source
HGNC:HGNC:16315
See related
Ensembl:ENSG00000157734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a sorting nexin that is found in the cytoplasm, where it interacts with membrane-bound phosphatidylinositol 3-phosphate. The encoded protein may play a role in intracellular trafficking. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in thyroid (RPKM 48.1), placenta (RPKM 36.5) and 25 other tissues See more
Orthologs

Genomic context

See SNX22 in Genome Data Viewer
Location:
15q22.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (64151698..64157481)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64443899..64449680)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene cytosolic iron-sulfur assembly component 2A Neighboring gene sorting nexin 1 Neighboring gene casein kinase 1 gamma 1 Neighboring gene peptidylprolyl isomerase B Neighboring gene Sharpr-MPRA regulatory region 12494 Neighboring gene PCNA clamp associated factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies SNX22, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13952

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033071.1 RefSeqGene

    Range
    5015..10765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024798.3NP_079074.2  sorting nexin-22

    See identical proteins and their annotated locations for NP_079074.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC100840, AK024014
    Consensus CDS
    CCDS10190.1
    UniProtKB/Swiss-Prot
    Q96L94
    UniProtKB/TrEMBL
    A0A024R5Y5
    Related
    ENSP00000323435.4, ENST00000325881.9
    Conserved Domains (1) summary
    cd06880
    Location:2116
    PX_SNX22; The phosphoinositide binding Phox Homology domain of Sorting Nexin 22

RNA

  1. NR_073534.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of a coding exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC100840, AK024014, BC019655

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    64151698..64157481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254677.3XP_005254734.1  sorting nexin-22 isoform X1

    See identical proteins and their annotated locations for XP_005254734.1

    UniProtKB/TrEMBL
    Q6ZTF9
    Conserved Domains (1) summary
    cl02563
    Location:288
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. XM_017022581.1XP_016878070.1  sorting nexin-22 isoform X2

    Related
    ENST00000557789.5
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