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RNF122 ring finger protein 122 [ Homo sapiens (human) ]

Gene ID: 79845, updated on 2-Mar-2021

Summary

Official Symbol
RNF122provided by HGNC
Official Full Name
ring finger protein 122provided by HGNC
Primary source
HGNC:HGNC:21147
See related
Ensembl:ENSG00000133874
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in gall bladder (RPKM 7.2), adrenal (RPKM 6.8) and 25 other tissues See more
Orthologs
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Genomic context

See RNF122 in Genome Data Viewer
Location:
8p12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (33547754..33567128, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (33405272..33424646, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene thymosin beta 4 X-linked pseudogene Neighboring gene ribosomal protein L10 pseudogene 18 Neighboring gene RNA, 7SL, cytoplasmic 621, pseudogene Neighboring gene dual specificity phosphatase 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12526, MGC126622

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024787.3NP_079063.2  RING finger protein 122

    See identical proteins and their annotated locations for NP_079063.2

    Status: REVIEWED

    Source sequence(s)
    AC013603, BC093884, DA610129, DA904646
    Consensus CDS
    CCDS6091.1
    UniProtKB/Swiss-Prot
    Q9H9V4
    Related
    ENSP00000256257.1, ENST00000256257.2
    Conserved Domains (1) summary
    cd16469
    Location:91137
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    33547754..33567128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013846.1XP_016869335.1  RING finger protein 122 isoform X1

    Conserved Domains (1) summary
    pfam13639
    Location:68109
    zf-RING_2; Ring finger domain
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