U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AGBL2 AGBL carboxypeptidase 2 [ Homo sapiens (human) ]

Gene ID: 79841, updated on 29-Oct-2022

Summary

Official Symbol
AGBL2provided by HGNC
Official Full Name
AGBL carboxypeptidase 2provided by HGNC
Primary source
HGNC:HGNC:26296
See related
Ensembl:ENSG00000165923 MIM:617345; AllianceGenome:HGNC:26296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCP2
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in protein side chain deglutamylation. Located in centriole and ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 8.5), lung (RPKM 1.3) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See AGBL2 in Genome Data Viewer
Location:
11p11.2
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (47659591..47715369, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (47824574..47880377, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47681143..47736921, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 4 Neighboring gene mitochondrial carrier 2 Neighboring gene formin binding protein 4 Neighboring gene nucleoporin 160 Neighboring gene RNA, 5S ribosomal pseudogene 340

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23598

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metallocarboxypeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein side chain deglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein side chain deglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cytosolic carboxypeptidase 2
Names
ATP/GTP binding protein like 2
cytoplasmic carboxypeptidase 2
protein deglutamylase CCP2
testis tissue sperm-binding protein Li 96mP
NP_079059.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024783.4NP_079059.2  cytosolic carboxypeptidase 2

    See identical proteins and their annotated locations for NP_079059.2

    Status: VALIDATED

    Source sequence(s)
    AC021443, BC036234
    Consensus CDS
    CCDS7944.1
    UniProtKB/Swiss-Prot
    Q5U5Z8, Q9H5C0
    UniProtKB/TrEMBL
    A0A140VKH9
    Related
    ENSP00000435582.1, ENST00000525123.6
    Conserved Domains (2) summary
    cd06907
    Location:407666
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam13900
    Location:105120
    GVQW; Putative domain of unknown function

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    47659591..47715369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_019805496.1 Reference GRCh38.p14 PATCHES

    Range
    91958..147736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    47824574..47880377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)