Format

Send to:

Choose Destination

AGBL2 AGBL carboxypeptidase 2 [ Homo sapiens (human) ]

Gene ID: 79841, updated on 27-Nov-2021

Summary

Official Symbol
AGBL2provided by HGNC
Official Full Name
AGBL carboxypeptidase 2provided by HGNC
Primary source
HGNC:HGNC:26296
See related
Ensembl:ENSG00000165923 MIM:617345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCP2
Expression
Biased expression in testis (RPKM 8.5), lung (RPKM 1.3) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See AGBL2 in Genome Data Viewer
Location:
11p11.2
Exon count:
24
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (47659168..47715382, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47681143..47736921, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 4 Neighboring gene mitochondrial carrier 2 Neighboring gene formin binding protein 4 Neighboring gene nucleoporin 160 Neighboring gene RNA, 5S ribosomal pseudogene 340

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23598

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metallocarboxypeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein side chain deglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein side chain deglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cytosolic carboxypeptidase 2
Names
ATP/GTP binding protein like 2
cytoplasmic carboxypeptidase 2
protein deglutamylase CCP2
testis tissue sperm-binding protein Li 96mP
NP_079059.2
XP_005253195.1
XP_005253196.1
XP_005253197.1
XP_005253198.1
XP_006718390.1
XP_006718391.1
XP_011518674.1
XP_011518675.1
XP_011518676.1
XP_011518677.1
XP_011518678.1
XP_011518679.1
XP_011518680.1
XP_011518681.1
XP_011518683.1
XP_016873820.1
XP_016873821.1
XP_016873822.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024783.4NP_079059.2  cytosolic carboxypeptidase 2

    See identical proteins and their annotated locations for NP_079059.2

    Status: VALIDATED

    Source sequence(s)
    AC021443, BC036234
    Consensus CDS
    CCDS7944.1
    UniProtKB/Swiss-Prot
    Q5U5Z8
    UniProtKB/TrEMBL
    A0A140VKH9
    Related
    ENSP00000435582.1, ENST00000525123.6
    Conserved Domains (2) summary
    cd06907
    Location:407666
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam13900
    Location:105120
    GVQW; Putative domain of unknown function

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    47659168..47715382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520373.3XP_011518675.1  cytosolic carboxypeptidase 2 isoform X2

    Conserved Domains (1) summary
    cd06907
    Location:369628
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  2. XM_006718328.4XP_006718391.1  cytosolic carboxypeptidase 2 isoform X9

    Conserved Domains (1) summary
    cd06907
    Location:351610
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  3. XM_011520381.3XP_011518683.1  cytosolic carboxypeptidase 2 isoform X12

    Conserved Domains (1) summary
    cd06907
    Location:369628
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  4. XM_005253140.5XP_005253197.1  cytosolic carboxypeptidase 2 isoform X10

    Conserved Domains (1) summary
    cd06907
    Location:369628
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  5. XM_005253139.5XP_005253196.1  cytosolic carboxypeptidase 2 isoform X4

    Conserved Domains (1) summary
    cd06907
    Location:369628
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  6. XM_005253138.5XP_005253195.1  cytosolic carboxypeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_005253195.1

    Conserved Domains (1) summary
    cd06907
    Location:369628
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  7. XM_011520372.3XP_011518674.1  cytosolic carboxypeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_011518674.1

    Related
    ENSP00000436630.1, ENST00000528244.5
    Conserved Domains (1) summary
    cd06907
    Location:369628
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  8. XM_011520375.3XP_011518677.1  cytosolic carboxypeptidase 2 isoform X8

    Conserved Domains (1) summary
    cd06907
    Location:324583
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  9. XM_006718327.4XP_006718390.1  cytosolic carboxypeptidase 2 isoform X3

    Conserved Domains (1) summary
    cd06907
    Location:351610
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  10. XM_011520374.3XP_011518676.1  cytosolic carboxypeptidase 2 isoform X5

    Conserved Domains (1) summary
    cd06907
    Location:333592
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  11. XM_011520376.3XP_011518678.1  cytosolic carboxypeptidase 2 isoform X11

    See identical proteins and their annotated locations for XP_011518678.1

    Conserved Domains (2) summary
    cd06907
    Location:280530
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:132259
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  12. XM_011520379.2XP_011518681.1  cytosolic carboxypeptidase 2 isoform X11

    See identical proteins and their annotated locations for XP_011518681.1

    Conserved Domains (2) summary
    cd06907
    Location:280530
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:132259
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  13. XM_011520378.2XP_011518680.1  cytosolic carboxypeptidase 2 isoform X11

    See identical proteins and their annotated locations for XP_011518680.1

    Conserved Domains (2) summary
    cd06907
    Location:280530
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:132259
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  14. XM_017018332.1XP_016873821.1  cytosolic carboxypeptidase 2 isoform X7

  15. XM_011520377.2XP_011518679.1  cytosolic carboxypeptidase 2 isoform X11

    See identical proteins and their annotated locations for XP_011518679.1

    Conserved Domains (2) summary
    cd06907
    Location:280530
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:132259
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  16. XM_017018331.2XP_016873820.1  cytosolic carboxypeptidase 2 isoform X6

  17. XM_017018333.2XP_016873822.1  cytosolic carboxypeptidase 2 isoform X14

  18. XM_005253141.5XP_005253198.1  cytosolic carboxypeptidase 2 isoform X13

    Conserved Domains (1) summary
    cl11393
    Location:369506
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RNA

  1. XR_001747981.2 RNA Sequence

  2. XR_930909.3 RNA Sequence

  3. XR_930908.3 RNA Sequence

  4. XR_242824.5 RNA Sequence

  5. XR_428852.4 RNA Sequence

  6. XR_242823.5 RNA Sequence

  7. XR_930911.3 RNA Sequence

  8. XR_930910.3 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_019805496.1 Reference GRCh38.p13 PATCHES

    Range
    91958..147736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center