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LONRF3 LON peptidase N-terminal domain and ring finger 3 [ Homo sapiens (human) ]

Gene ID: 79836, updated on 11-Jun-2021

Summary

Official Symbol
LONRF3provided by HGNC
Official Full Name
LON peptidase N-terminal domain and ring finger 3provided by HGNC
Primary source
HGNC:HGNC:21152
See related
Ensembl:ENSG00000175556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF127
Summary
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple alternatively spliced transcript variants have been suggested, but their full length natures are not clear. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 3.2), liver (RPKM 3.1) and 25 other tissues See more
Orthologs
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Genomic context

See LONRF3 in Genome Data Viewer
Location:
Xq24
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (118974614..119022925)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (118108577..118152318)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1285 Neighboring gene AKR7A2P pseudogene 1 Neighboring gene COBL pseudogene 1 Neighboring gene cancer/testis antigen family 47 member A11 pseudogene Neighboring gene KIAA1210

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of LON peptidase N-terminal domain and ring finger 3 (LONRF3) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22612, MGC119463, MGC119465

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
LON peptidase N-terminal domain and RING finger protein 3
Names
ring finger protein 127

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012577.1 RefSeqGene

    Range
    4869..48606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001031855.3NP_001027026.1  LON peptidase N-terminal domain and RING finger protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001027026.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK290198, BC100671, DA249558
    Consensus CDS
    CCDS35374.1
    UniProtKB/Swiss-Prot
    Q496Y0
    UniProtKB/TrEMBL
    A8K2D3
    Related
    ENSP00000360690.3, ENST00000371628.8
    Conserved Domains (6) summary
    cd00162
    Location:466505
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl19481
    Location:566744
    LON; Found in ATP-dependent protease La (LON)
    sd00006
    Location:243271
    TPR; TPR repeat [structural motif]
    pfam02190
    Location:555756
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    pfam13414
    Location:242308
    TPR_11; TPR repeat
    cl17238
    Location:158195
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. NM_001289109.1NP_001276038.1  LON peptidase N-terminal domain and RING finger protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001276038.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in a protein (isoform 3) which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK097641, AK290198, AL772284, BC098283
    Consensus CDS
    CCDS76014.1
    UniProtKB/TrEMBL
    A8K2D3, B3KUN7
    Related
    ENSP00000408894.2, ENST00000422289.3
    Conserved Domains (3) summary
    cd00162
    Location:210249
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl19481
    Location:300488
    LON; Found in ATP-dependent protease La (LON)
    pfam02190
    Location:299500
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
  3. NM_024778.5NP_079054.3  LON peptidase N-terminal domain and RING finger protein 3 isoform 2

    See identical proteins and their annotated locations for NP_079054.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AK290198, BC103491, DA249558
    Consensus CDS
    CCDS14575.1
    UniProtKB/Swiss-Prot
    Q496Y0
    UniProtKB/TrEMBL
    A8K2D3
    Related
    ENSP00000307732.7, ENST00000304778.11
    Conserved Domains (6) summary
    cd00162
    Location:425464
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl19481
    Location:525703
    LON; Found in ATP-dependent protease La (LON)
    sd00006
    Location:243271
    TPR; TPR repeat [structural motif]
    pfam02190
    Location:514715
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    pfam13414
    Location:242308
    TPR_11; TPR repeat
    cl17238
    Location:158195
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

  1. NR_110311.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 3' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK091777, AK290198, DA249558
    Related
    ENST00000481285.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    118974614..119022925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262476.2XP_005262533.1  LON peptidase N-terminal domain and RING finger protein 3 isoform X1

    Conserved Domains (6) summary
    cd00162
    Location:518557
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl19481
    Location:618796
    LON; Found in ATP-dependent protease La (LON)
    sd00006
    Location:243271
    TPR; TPR repeat [structural motif]
    pfam02190
    Location:607808
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    pfam13414
    Location:242308
    TPR_11; TPR repeat
    cl17238
    Location:158195
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. XM_017029845.1XP_016885334.1  LON peptidase N-terminal domain and RING finger protein 3 isoform X3

  3. XM_011531398.2XP_011529700.1  LON peptidase N-terminal domain and RING finger protein 3 isoform X2

    Conserved Domains (6) summary
    cd00162
    Location:518557
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl19481
    Location:618653
    LON; Found in ATP-dependent protease La (LON)
    sd00006
    Location:243271
    TPR; TPR repeat [structural motif]
    pfam02190
    Location:607650
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    pfam13414
    Location:242308
    TPR_11; TPR repeat
    cl17238
    Location:158195
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

  1. XR_938554.2 RNA Sequence

  2. XR_001755725.1 RNA Sequence

  3. XR_001755724.2 RNA Sequence

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