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PEAK1 pseudopodium enriched atypical kinase 1 [ Homo sapiens (human) ]

Gene ID: 79834, updated on 4-Oct-2020

Summary

Official Symbol
PEAK1provided by HGNC
Official Full Name
pseudopodium enriched atypical kinase 1provided by HGNC
Primary source
HGNC:HGNC:29431
See related
Ensembl:ENSG00000173517 MIM:614248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGK269
Summary
This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in spleen (RPKM 15.5), lung (RPKM 8.0) and 23 other tissues See more
Orthologs

Genomic context

See PEAK1 in Genome Data Viewer
Location:
15q24.3
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (77100829..77420699, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (77400498..77712446, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene proline-serine-threonine phosphatase interacting protein 1 Neighboring gene tetraspanin 3 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 27 Neighboring gene long intergenic non-protein coding RNA 597 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene high mobility group 20A Neighboring gene uncharacterized LOC101929457

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21140, FLJ34483, KIAA2002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell migration IDA
Inferred from Direct Assay
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inactive tyrosine-protein kinase PEAK1
Names
NKF3 kinase family member
sugen kinase 269
tyrosine-protein kinase SgK269
NP_001371955.1
NP_001371956.1
NP_079052.2
XP_005254727.1
XP_005254728.1
XP_005254730.1
XP_005254731.1
XP_005254732.1
XP_011520335.1
XP_011520336.1
XP_011520337.1
XP_011520338.1
XP_011520339.1
XP_011520340.1
XP_011520341.1
XP_011520342.1
XP_011520343.1
XP_011520344.1
XP_024305824.1
XP_024305825.1
XP_024305826.1
XP_024305827.1
XP_024305828.1
XP_024305829.1
XP_024305830.1
XP_024305831.1
XP_024305832.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034037.1 RefSeqGene

    Range
    5001..316949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001385026.1NP_001371955.1  inactive tyrosine-protein kinase PEAK1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AC060773, AC087465, AC090984, AC107883
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001385027.1NP_001371956.1  inactive tyrosine-protein kinase PEAK1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC060773, AC087465, AC090984
  3. NM_001387085.1NP_001374014.1  inactive tyrosine-protein kinase PEAK1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1, 2, and 5, encodes isoform a.
    Source sequence(s)
    AC060773, AC087465, AC090984, AC107883
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001387086.1NP_001374015.1  inactive tyrosine-protein kinase PEAK1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 2, and 4, encodes isoform a.
    Source sequence(s)
    AC060773, AC087465, AC090984, AC107883
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  5. NM_024776.5NP_079052.2  inactive tyrosine-protein kinase PEAK1 isoform a

    See identical proteins and their annotated locations for NP_079052.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AC060773, AC087465, AC090984, AC107883
    Consensus CDS
    CCDS42062.1
    UniProtKB/Swiss-Prot
    Q9H792
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    77100829..77420699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522040.1XP_011520342.1  inactive tyrosine-protein kinase PEAK1 isoform X2

  2. XM_024450059.1XP_024305827.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  3. XM_024450064.1XP_024305832.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  4. XM_024450062.1XP_024305830.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  5. XM_024450056.1XP_024305824.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  6. XM_024450057.1XP_024305825.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  7. XM_024450060.1XP_024305828.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  8. XM_005254674.2XP_005254731.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_005254731.1

    UniProtKB/Swiss-Prot
    Q9H792
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  9. XM_005254673.2XP_005254730.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_005254730.1

    UniProtKB/Swiss-Prot
    Q9H792
    Related
    ENSP00000452796.2, ENST00000560626.6
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  10. XM_005254671.2XP_005254728.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_005254728.1

    UniProtKB/Swiss-Prot
    Q9H792
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  11. XM_005254670.2XP_005254727.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_005254727.1

    UniProtKB/Swiss-Prot
    Q9H792
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  12. XM_011522033.2XP_011520335.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_011520335.1

    UniProtKB/Swiss-Prot
    Q9H792
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  13. XM_011522038.2XP_011520340.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_011520340.1

    UniProtKB/Swiss-Prot
    Q9H792
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  14. XM_011522039.2XP_011520341.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_011520341.1

    UniProtKB/Swiss-Prot
    Q9H792
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  15. XM_011522034.2XP_011520336.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_011520336.1

    UniProtKB/Swiss-Prot
    Q9H792
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  16. XM_011522036.2XP_011520338.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_011520338.1

    UniProtKB/Swiss-Prot
    Q9H792
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  17. XM_011522037.2XP_011520339.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_011520339.1

    UniProtKB/Swiss-Prot
    Q9H792
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  18. XM_011522035.2XP_011520337.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_011520337.1

    UniProtKB/Swiss-Prot
    Q9H792
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  19. XM_024450058.1XP_024305826.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  20. XM_024450061.1XP_024305829.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  21. XM_024450063.1XP_024305831.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  22. XM_005254675.4XP_005254732.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_005254732.1

    UniProtKB/Swiss-Prot
    Q9H792
    Related
    ENSP00000309230.4, ENST00000312493.5
    Conserved Domains (1) summary
    cl21453
    Location:15031668
    PKc_like; Protein Kinases, catalytic domain
  23. XM_011522042.2XP_011520344.1  inactive tyrosine-protein kinase PEAK1 isoform X4

  24. XM_011522041.1XP_011520343.1  inactive tyrosine-protein kinase PEAK1 isoform X3

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