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ZMYM1 zinc finger MYM-type containing 1 [ Homo sapiens (human) ]

Gene ID: 79830, updated on 21-Dec-2019

Summary

Official Symbol
ZMYM1provided by HGNC
Official Full Name
zinc finger MYM-type containing 1provided by HGNC
Primary source
HGNC:HGNC:26253
See related
Ensembl:ENSG00000197056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYM
Expression
Ubiquitous expression in testis (RPKM 3.0), ovary (RPKM 2.8) and 25 other tissues See more
Orthologs

Genomic context

See ZMYM1 in Genome Data Viewer
Location:
1p34.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (35059786..35116458)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (35525387..35581460)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger MYM-type containing 6 Neighboring gene ribosomal protein L12 pseudogene 45 Neighboring gene EF-hand calcium binding domain 14 pseudogene 1 Neighboring gene uncharacterized LOC105378644

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23151, FLJ43753

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger MYM-type protein 1
Names
zinc finger, MYM domain containing 1
zinc finger, MYM-type 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289088.1NP_001276017.1  zinc finger MYM-type protein 1 isoform a

    See identical proteins and their annotated locations for NP_001276017.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 4, and 5 encode the same protein (isoform a).
    Source sequence(s)
    AK026804, AK125741, BC037313, BX537537
    Consensus CDS
    CCDS41302.1
    UniProtKB/Swiss-Prot
    Q5SVZ6
    UniProtKB/TrEMBL
    A0A1B0GXA6, Q9H5R2
    Related
    ENSP00000482579.1, ENST00000611874.4
    Conserved Domains (5) summary
    smart00597
    Location:452531
    ZnF_TTF; zinc finger in transposases and transcription factors
    smart00746
    Location:135175
    TRASH; metallochaperone-like domain
    pfam05699
    Location:10291118
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam06467
    Location:83121
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:496728
    DUF4371; Domain of unknown function (DUF4371)
  2. NM_001289089.1NP_001276018.1  zinc finger MYM-type protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AK026804, AK299779, BC037313, BX537537
    UniProtKB/Swiss-Prot
    Q5SVZ6
    UniProtKB/TrEMBL
    B4DSJ9, Q9H5R2
    Conserved Domains (4) summary
    smart00597
    Location:433512
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:10101099
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam06467
    Location:130171
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:477709
    DUF4371; Domain of unknown function (DUF4371)
  3. NM_001289090.1NP_001276019.1  zinc finger MYM-type protein 1 isoform a

    See identical proteins and their annotated locations for NP_001276019.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform a).
    Source sequence(s)
    AK026804, AK299779, BC037313, BX537537
    Consensus CDS
    CCDS41302.1
    UniProtKB/Swiss-Prot
    Q5SVZ6
    UniProtKB/TrEMBL
    B4DSJ9, Q9H5R2
    Related
    ENSP00000362427.1, ENST00000373330.1
    Conserved Domains (5) summary
    smart00597
    Location:452531
    ZnF_TTF; zinc finger in transposases and transcription factors
    smart00746
    Location:135175
    TRASH; metallochaperone-like domain
    pfam05699
    Location:10291118
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam06467
    Location:83121
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:496728
    DUF4371; Domain of unknown function (DUF4371)
  4. NM_001289091.1NP_001276020.1  zinc finger MYM-type protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AK026804, AK096206, AK299779, BC037313
    UniProtKB/TrEMBL
    B4DSJ9, Q9H5R2
    Conserved Domains (3) summary
    smart00597
    Location:92171
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:700758
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:133367
    DUF4371; Domain of unknown function (DUF4371)
  5. NM_001319955.1NP_001306884.1  zinc finger MYM-type protein 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK026804, AK125741, AK299779, BC037313, BX537537, BX648307
    UniProtKB/Swiss-Prot
    Q5SVZ6
    UniProtKB/TrEMBL
    A0A1B0GXA6, B4DSJ9, Q9H5R2
    Conserved Domains (5) summary
    smart00597
    Location:377456
    ZnF_TTF; zinc finger in transposases and transcription factors
    smart00746
    Location:60100
    TRASH; metallochaperone-like domain
    pfam05699
    Location:9541043
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam06467
    Location:846
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:421653
    DUF4371; Domain of unknown function (DUF4371)
  6. NM_024772.5NP_079048.3  zinc finger MYM-type protein 1 isoform a

    See identical proteins and their annotated locations for NP_079048.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform a).
    Source sequence(s)
    AL607089
    Consensus CDS
    CCDS41302.1
    UniProtKB/Swiss-Prot
    Q5SVZ6
    UniProtKB/TrEMBL
    B4DSJ9, Q9H5R2
    Related
    ENSP00000352920.4, ENST00000359858.9
    Conserved Domains (5) summary
    smart00597
    Location:452531
    ZnF_TTF; zinc finger in transposases and transcription factors
    smart00746
    Location:135175
    TRASH; metallochaperone-like domain
    pfam05699
    Location:10291118
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam06467
    Location:83121
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:496728
    DUF4371; Domain of unknown function (DUF4371)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    35059786..35116458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449828.1XP_024305596.1  zinc finger MYM-type protein 1 isoform X6

    Conserved Domains (3) summary
    smart00597
    Location:261340
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:838927
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:302536
    DUF4371; Domain of unknown function (DUF4371)
  2. XM_017002359.1XP_016857848.1  zinc finger MYM-type protein 1 isoform X5

  3. XM_024449827.1XP_024305595.1  zinc finger MYM-type protein 1 isoform X6

    Conserved Domains (3) summary
    smart00597
    Location:261340
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:838927
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:302536
    DUF4371; Domain of unknown function (DUF4371)
  4. XM_024449824.1XP_024305592.1  zinc finger MYM-type protein 1 isoform X6

    Conserved Domains (3) summary
    smart00597
    Location:261340
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:838927
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:302536
    DUF4371; Domain of unknown function (DUF4371)
  5. XM_024449825.1XP_024305593.1  zinc finger MYM-type protein 1 isoform X6

    Conserved Domains (3) summary
    smart00597
    Location:261340
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:838927
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:302536
    DUF4371; Domain of unknown function (DUF4371)
  6. XM_024449823.1XP_024305591.1  zinc finger MYM-type protein 1 isoform X3

    Conserved Domains (4) summary
    smart00597
    Location:482561
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:10591148
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam06467
    Location:161201
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:523757
    DUF4371; Domain of unknown function (DUF4371)
  7. XM_011542163.3XP_011540465.2  zinc finger MYM-type protein 1 isoform X2

    Conserved Domains (4) summary
    smart00597
    Location:491570
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:10681157
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam06467
    Location:182222
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:532766
    DUF4371; Domain of unknown function (DUF4371)
  8. XM_024449833.1XP_024305601.1  zinc finger MYM-type protein 1 isoform X7

    Conserved Domains (3) summary
    smart00597
    Location:92171
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:700758
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:133367
    DUF4371; Domain of unknown function (DUF4371)
  9. XM_024449822.1XP_024305590.1  zinc finger MYM-type protein 1 isoform X1

    Conserved Domains (4) summary
    smart00597
    Location:503582
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:10801169
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam06467
    Location:182222
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:544778
    DUF4371; Domain of unknown function (DUF4371)
  10. XM_011542165.3XP_011540467.1  zinc finger MYM-type protein 1 isoform X6

    See identical proteins and their annotated locations for XP_011540467.1

    Conserved Domains (3) summary
    smart00597
    Location:261340
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:838927
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:302536
    DUF4371; Domain of unknown function (DUF4371)
  11. XM_017002360.2XP_016857849.1  zinc finger MYM-type protein 1 isoform X6

    Conserved Domains (3) summary
    smart00597
    Location:261340
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:838927
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:302536
    DUF4371; Domain of unknown function (DUF4371)
  12. XM_011542166.3XP_011540468.2  zinc finger MYM-type protein 1 isoform X8

    Related
    ENSP00000394233.1, ENST00000417119.5
    Conserved Domains (1) summary
    pfam06467
    Location:182222
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
  13. XM_017002358.1XP_016857847.1  zinc finger MYM-type protein 1 isoform X4

    Conserved Domains (5) summary
    smart00597
    Location:377456
    ZnF_TTF; zinc finger in transposases and transcription factors
    smart00746
    Location:60100
    TRASH; metallochaperone-like domain
    pfam05699
    Location:9541043
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam06467
    Location:846
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:421653
    DUF4371; Domain of unknown function (DUF4371)
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