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METTL8 methyltransferase 8, methylcytidine [ Homo sapiens (human) ]

Gene ID: 79828, updated on 4-Dec-2022

Summary

Official Symbol
METTL8provided by HGNC
Official Full Name
methyltransferase 8, methylcytidineprovided by HGNC
Primary source
HGNC:HGNC:25856
See related
Ensembl:ENSG00000123600 MIM:609525; AllianceGenome:HGNC:25856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIP
Summary
Enables mRNA methyltransferase activity. Involved in mRNA methylation. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 2.5), esophagus (RPKM 2.0) and 24 other tissues See more
Orthologs
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Genomic context

See METTL8 in Genome Data Viewer
Location:
2q31.1
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (171315746..171434772, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (171792877..171911912, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (172172256..172291282, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107983995 Neighboring gene uncharacterized LOC105373737 Neighboring gene small integral membrane protein 26-like Neighboring gene Sharpr-MPRA regulatory region 707 Neighboring gene Sharpr-MPRA regulatory region 8774 Neighboring gene ribosomal protein S26 pseudogene 20 Neighboring gene DDB1 and CUL4 associated factor 17 Neighboring gene CRISPRi-validated cis-regulatory element chr2.5458 Neighboring gene death associated protein 3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13334, FLJ13984, FLJ31054, FLJ42098, FLJ77788

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in mRNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA C3-cytosine methylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NOT is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
NOT is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial
Names
mRNA N(3)-methylcytidine methyltransferase METTL8
methyltransferase like 8
methyltransferase-like protein 8
tension-induced/inhibited protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321154.2NP_001308083.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK024046, AK124092, BC025250, BM930105
    Consensus CDS
    CCDS2242.2
    UniProtKB/Swiss-Prot
    Q9H825
    UniProtKB/TrEMBL
    B3KW44, E7ETE0
    Related
    ENSP00000364407.4, ENST00000375258.9
    Conserved Domains (1) summary
    pfam13649
    Location:200303
    Methyltransf_25; Methyltransferase domain
  2. NM_001321155.2NP_001308084.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK024046, AK124092, BC025250, BM930105
    Consensus CDS
    CCDS2242.2
    UniProtKB/Swiss-Prot
    Q9H825
    UniProtKB/TrEMBL
    B3KW44, E7ETE0
    Conserved Domains (1) summary
    pfam13649
    Location:200303
    Methyltransf_25; Methyltransferase domain
  3. NM_001321156.2NP_001308085.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK124092, BM930105
    Consensus CDS
    CCDS2242.2
    UniProtKB/Swiss-Prot
    Q9H825
    UniProtKB/TrEMBL
    B3KW44, E7ETE0
    Conserved Domains (1) summary
    pfam13649
    Location:200303
    Methyltransf_25; Methyltransferase domain
  4. NM_001321157.2NP_001308086.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK124092, AK297141, BC025250, BM930105
    UniProtKB/Swiss-Prot
    Q9H825
    UniProtKB/TrEMBL
    B3KW44, B4DLT0
    Conserved Domains (1) summary
    pfam13649
    Location:248351
    Methyltransf_25; Methyltransferase domain
  5. NM_001321158.2NP_001308087.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007739, AC008065, AK297141, BM930105
    UniProtKB/TrEMBL
    B4DLT0
    Conserved Domains (1) summary
    pfam13649
    Location:155258
    Methyltransf_25; Methyltransferase domain
  6. NM_001321159.2NP_001308088.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK124092, BC025250, BM930105
    UniProtKB/Swiss-Prot
    Q9H825
    UniProtKB/TrEMBL
    B3KW44
    Conserved Domains (1) summary
    pfam13649
    Location:150253
    Methyltransf_25; Methyltransferase domain
  7. NM_001321160.2NP_001308089.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC007739, AC008065, BC025250, BM930105
    Consensus CDS
    CCDS82532.1
    UniProtKB/Swiss-Prot
    Q53TQ0, Q9H825
    Related
    ENSP00000376382.2, ENST00000392604.6
    Conserved Domains (1) summary
    pfam13649
    Location:200286
    Methyltransf_25; Methyltransferase domain
  8. NM_001321161.2NP_001308090.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC007739, AC007969, AC008065, BM930105, KF459614
    Conserved Domains (1) summary
    pfam13649
    Location:155241
    Methyltransf_25; Methyltransferase domain
  9. NM_001321162.2NP_001308091.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK024046, BM930105
    Consensus CDS
    CCDS82531.1
    UniProtKB/Swiss-Prot
    Q9H825
    Related
    ENSP00000409025.1, ENST00000447486.5
    Conserved Domains (1) summary
    pfam13649
    Location:150236
    Methyltransf_25; Methyltransferase domain
  10. NM_024770.5NP_079046.2  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_079046.2

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK124092, AK292108, BM930105
    Consensus CDS
    CCDS2242.2
    UniProtKB/TrEMBL
    A8K7U3, B3KW44, B4DLT0, E7ETE0
    Related
    ENSP00000480056.1, ENST00000612742.5
    Conserved Domains (1) summary
    pfam13649
    Location:200303
    Methyltransf_25; Methyltransferase domain

RNA

  1. NR_135568.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007739, AC008065, BM930105, DB031573, KF459614

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    171315746..171434772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    171792877..171911912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)