Format

Send to:

Choose Destination

METTL8 methyltransferase like 8 [ Homo sapiens (human) ]

Gene ID: 79828, updated on 13-Mar-2020

Summary

Official Symbol
METTL8provided by HGNC
Official Full Name
methyltransferase like 8provided by HGNC
Primary source
HGNC:HGNC:25856
See related
Ensembl:ENSG00000123600 MIM:609525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIP
Expression
Ubiquitous expression in skin (RPKM 2.5), esophagus (RPKM 2.0) and 24 other tissues See more
Orthologs

Genomic context

See METTL8 in Genome Data Viewer
Location:
2q31.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (171315746..171434803, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (172173912..172291312, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107983995 Neighboring gene uncharacterized LOC105373737 Neighboring gene small integral membrane protein 26-like Neighboring gene ribosomal protein S26 pseudogene 20 Neighboring gene DDB1 and CUL4 associated factor 17 Neighboring gene CRISPRi-validated cis-regulatory element chr2.5458 Neighboring gene death associated protein 3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13334, FLJ13984, FLJ31054, FLJ42098, FLJ77788

Gene Ontology Provided by GOA

Function Evidence Code Pubs
tRNA (cytosine-3-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
tRNA methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mRNA N(3)-methylcytidine methyltransferase METTL8
Names
methyltransferase-like protein 8
tension-induced/inhibited protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321154.2NP_001308083.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK024046, AK124092, BC025250, BM930105
    Consensus CDS
    CCDS2242.2
    UniProtKB/Swiss-Prot
    Q9H825
    UniProtKB/TrEMBL
    B3KW44
    Related
    ENSP00000364407.3, ENST00000375258.8
    Conserved Domains (2) summary
    COG0500
    Location:196389
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:201305
    Methyltransf_12; Methyltransferase domain
  2. NM_001321155.2NP_001308084.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK024046, AK124092, BC025250, BM930105
    Consensus CDS
    CCDS2242.2
    UniProtKB/Swiss-Prot
    Q9H825
    UniProtKB/TrEMBL
    B3KW44
    Conserved Domains (2) summary
    COG0500
    Location:196389
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:201305
    Methyltransf_12; Methyltransferase domain
  3. NM_001321156.2NP_001308085.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK124092, BM930105
    Consensus CDS
    CCDS2242.2
    UniProtKB/Swiss-Prot
    Q9H825
    UniProtKB/TrEMBL
    B3KW44
    Conserved Domains (2) summary
    COG0500
    Location:196389
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:201305
    Methyltransf_12; Methyltransferase domain
  4. NM_001321157.2NP_001308086.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK124092, AK297141, BC025250, BM930105
    UniProtKB/Swiss-Prot
    Q9H825
    UniProtKB/TrEMBL
    B3KW44, B4DLT0
    Conserved Domains (2) summary
    COG0500
    Location:244437
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:249353
    Methyltransf_12; Methyltransferase domain
  5. NM_001321158.2NP_001308087.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007739, AC008065, AK297141, BM930105
    UniProtKB/TrEMBL
    B4DLT0
    Conserved Domains (2) summary
    COG0500
    Location:151344
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:156260
    Methyltransf_12; Methyltransferase domain
  6. NM_001321159.2NP_001308088.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK124092, BC025250, BM930105
    UniProtKB/Swiss-Prot
    Q9H825
    UniProtKB/TrEMBL
    B3KW44
    Conserved Domains (2) summary
    COG0500
    Location:146339
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:151255
    Methyltransf_12; Methyltransferase domain
  7. NM_001321160.2NP_001308089.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC007739, AC008065, BC025250, BM930105
    Consensus CDS
    CCDS82532.1
    UniProtKB/Swiss-Prot
    Q9H825
    Related
    ENSP00000376382.2, ENST00000392604.6
    Conserved Domains (1) summary
    pfam08242
    Location:201289
    Methyltransf_12; Methyltransferase domain
  8. NM_001321161.2NP_001308090.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC007739, AC007969, AC008065, BM930105, KF459614
    Conserved Domains (1) summary
    pfam08242
    Location:156244
    Methyltransf_12; Methyltransferase domain
  9. NM_001321162.2NP_001308091.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK024046, BM930105
    Consensus CDS
    CCDS82531.1
    UniProtKB/Swiss-Prot
    Q9H825
    Related
    ENSP00000409025.1, ENST00000447486.5
    Conserved Domains (1) summary
    pfam13649
    Location:150236
    Methyltransf_25; Methyltransferase domain
  10. NM_024770.4NP_079046.2  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform 1

    See identical proteins and their annotated locations for NP_079046.2

    Status: VALIDATED

    Source sequence(s)
    AC007739, AK124092, AK292108, AK297141, BM930105
    Consensus CDS
    CCDS2242.2
    UniProtKB/TrEMBL
    A8K7U3, B3KW44, B4DLT0
    Related
    ENSP00000480056.1, ENST00000612742.4
    Conserved Domains (2) summary
    COG0500
    Location:196389
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:201305
    Methyltransf_12; Methyltransferase domain

RNA

  1. NR_135568.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007739, AC008065, BM930105, DB031573, KF459614

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    171315746..171434803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004987.2XP_016860476.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform X4

  2. XM_017004986.2XP_016860475.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform X2

  3. XM_011511875.3XP_011510177.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform X3

  4. XM_017004984.2XP_016860473.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform X1

  5. XM_017004985.2XP_016860474.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform X2

  6. XM_017004989.2XP_016860478.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform X2

  7. XM_017004988.2XP_016860477.1  mRNA N(3)-methylcytidine methyltransferase METTL8 isoform X5

RNA

  1. XR_002959340.1 RNA Sequence

  2. XR_002959341.1 RNA Sequence

  3. XR_923028.3 RNA Sequence

  4. XR_923027.3 RNA Sequence

  5. XR_001738956.2 RNA Sequence

  6. XR_001738955.1 RNA Sequence

Support Center