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CAMKMT calmodulin-lysine N-methyltransferase [ Homo sapiens (human) ]

Gene ID: 79823, updated on 1-Jun-2020

Summary

Official Symbol
CAMKMTprovided by HGNC
Official Full Name
calmodulin-lysine N-methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:26276
See related
Ensembl:ENSG00000143919 MIM:609559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cam; KMT; CLNMT; C2orf34; CaM KMT
Summary
This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. The protein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling. [provided by RefSeq, Sep 2012]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See CAMKMT in Genome Data Viewer
Location:
2p21
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (44361714..44772592)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (44589043..44999731)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene 19 Neighboring gene solute carrier family 3 member 1 Neighboring gene prolyl endopeptidase like Neighboring gene uncharacterized LOC107985878 Neighboring gene VISTA enhancer hs541 Neighboring gene uncharacterized LOC105374573

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
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NHGRI GWA Catalog
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NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23451

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calmodulin-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
peptidyl-lysine methylation IEA
Inferred from Electronic Annotation
more info
 
protein methylation TAS
Traceable Author Statement
more info
 
regulation of rhodopsin mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calmodulin-lysine N-methyltransferase
NP_079042.1
XP_011531413.1
XP_011531415.1
XP_016860459.1
XP_016860460.1
XP_016860461.1
XP_016860462.1
XP_016860463.1
XP_016860464.1
XP_016860465.1
XP_016860466.1
XP_016860467.1
XP_016860468.1
XP_016860469.1
XP_016860470.1
XP_016860471.1
XP_016860472.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032944.1 RefSeqGene

    Range
    5044..415689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024766.5NP_079042.1  calmodulin-lysine N-methyltransferase

    See identical proteins and their annotated locations for NP_079042.1

    Status: REVIEWED

    Source sequence(s)
    AI933944, AK027104, DA760277
    Consensus CDS
    CCDS1820.1
    UniProtKB/Swiss-Prot
    Q7Z624
    Related
    ENSP00000367755.3, ENST00000378494.8
    Conserved Domains (1) summary
    cl17173
    Location:113278
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    44361714..44772592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004971.1XP_016860460.1  calmodulin-lysine N-methyltransferase isoform X3

  2. XM_017004976.1XP_016860465.1  calmodulin-lysine N-methyltransferase isoform X6

  3. XM_017004978.1XP_016860467.1  calmodulin-lysine N-methyltransferase isoform X7

  4. XM_017004980.1XP_016860469.1  calmodulin-lysine N-methyltransferase isoform X9

  5. XM_017004977.1XP_016860466.1  calmodulin-lysine N-methyltransferase isoform X7

  6. XM_017004975.1XP_016860464.1  calmodulin-lysine N-methyltransferase isoform X5

  7. XM_017004981.1XP_016860470.1  calmodulin-lysine N-methyltransferase isoform X10

  8. XM_017004979.2XP_016860468.1  calmodulin-lysine N-methyltransferase isoform X8

  9. XM_017004970.1XP_016860459.1  calmodulin-lysine N-methyltransferase isoform X2

  10. XM_017004973.2XP_016860462.1  calmodulin-lysine N-methyltransferase isoform X4

  11. XM_017004974.2XP_016860463.1  calmodulin-lysine N-methyltransferase isoform X4

  12. XM_017004972.1XP_016860461.1  calmodulin-lysine N-methyltransferase isoform X4

  13. XM_011533111.2XP_011531413.1  calmodulin-lysine N-methyltransferase isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:113232
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  14. XM_017004983.2XP_016860472.1  calmodulin-lysine N-methyltransferase isoform X11

  15. XM_017004982.2XP_016860471.1  calmodulin-lysine N-methyltransferase isoform X11

  16. XM_011533113.3XP_011531415.1  calmodulin-lysine N-methyltransferase isoform X12

    See identical proteins and their annotated locations for XP_011531415.1

    UniProtKB/TrEMBL
    D6W5A4
    Related
    ENSP00000482360.1, ENST00000613618.1
    Conserved Domains (1) summary
    cl17173
    Location:2122
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. XR_001738950.1 RNA Sequence

  2. XR_001738953.1 RNA Sequence

  3. XR_001738951.1 RNA Sequence

  4. XR_001738952.1 RNA Sequence

  5. XR_001738954.1 RNA Sequence

  6. XR_001738949.2 RNA Sequence

  7. XR_939723.1 RNA Sequence

  8. XR_939722.2 RNA Sequence

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