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ST7 suppression of tumorigenicity 7 [ Homo sapiens (human) ]

Gene ID: 7982, updated on 3-May-2020

Summary

Official Symbol
ST7provided by HGNC
Official Full Name
suppression of tumorigenicity 7provided by HGNC
Primary source
HGNC:HGNC:11351
See related
Ensembl:ENSG00000004866 MIM:600833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HELG; RAY1; SEN4; TSG7; ETS7q; FAM4A; FAM4A1
Summary
The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 11.1), lung (RPKM 10.9) and 25 other tissues See more
Orthologs

Genomic context

See ST7 in Genome Data Viewer
Location:
7q31.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (116953501..117230176)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116593381..116870077)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375465 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4218 Neighboring gene RNA, 5S ribosomal pseudogene 239 Neighboring gene ST7 antisense RNA 1 Neighboring gene ST7 overlapping transcript 4 Neighboring gene tropomyosin 3 pseudogene 1 Neighboring gene microRNA 6132 Neighboring gene greater CFTR locus negative regulatory element NR4 Neighboring gene ST7 antisense RNA 2 Neighboring gene greater CFTR locus negative regulatory element CR10 Neighboring gene greater CFTR locus negative regulatory element CR11 Neighboring gene ST7 overlapping transcript 3 Neighboring gene uncharacterized LOC105375466 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like 2 pseudogene Neighboring gene MT-ND2 pseudogene 37

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp762O2113

Gene Ontology Provided by GOA

Process Evidence Code Pubs
extracellular matrix organization NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
suppressor of tumorigenicity 7 protein
Names
family with sequence similarity 4, subfamily A, member 1
suppression of tumorigenicity 7 (breast)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047088.1 RefSeqGene

    Range
    5175..281850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001369598.1NP_001356527.1  suppressor of tumorigenicity 7 protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Related
    ENSP00000325673.3, ENST00000323984.7
    Conserved Domains (1) summary
    pfam04184
    Location:19576
    ST7; ST7 protein
  2. NM_001369599.1NP_001356528.1  suppressor of tumorigenicity 7 protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Related
    ENSP00000377093.4, ENST00000393447.8
    Conserved Domains (1) summary
    pfam04184
    Location:6533
    ST7; ST7 protein
  3. NM_001369600.1NP_001356529.1  suppressor of tumorigenicity 7 protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Related
    ENSP00000377090.3, ENST00000393444.7
    Conserved Domains (1) summary
    pfam04184
    Location:6510
    ST7; ST7 protein
  4. NM_001369601.1NP_001356530.1  suppressor of tumorigenicity 7 protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Related
    ENSP00000377095.1, ENST00000393449.5
    Conserved Domains (1) summary
    pfam04184
    Location:19571
    ST7; ST7 protein
  5. NM_001369602.1NP_001356531.1  suppressor of tumorigenicity 7 protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Related
    ENSP00000411118.1, ENST00000432298.5
    Conserved Domains (1) summary
    pfam04184
    Location:4530
    ST7; ST7 protein
  6. NM_001369603.1NP_001356532.1  suppressor of tumorigenicity 7 protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Related
    ENSP00000414031.1, ENST00000422922.5
    Conserved Domains (1) summary
    pfam04184
    Location:4507
    ST7; ST7 protein
  7. NM_001369604.1NP_001356533.1  suppressor of tumorigenicity 7 protein isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC106873
    Conserved Domains (1) summary
    pfam04184
    Location:19523
    ST7; ST7 protein
  8. NM_001369606.1NP_001356535.1  suppressor of tumorigenicity 7 protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Related
    ENSP00000377089.1, ENST00000393443.5
    Conserved Domains (1) summary
    pfam04184
    Location:1526
    ST7; ST7 protein
  9. NM_001369607.1NP_001356536.1  suppressor of tumorigenicity 7 protein isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Conserved Domains (1) summary
    pfam04184
    Location:1503
    ST7; ST7 protein
  10. NM_018412.4NP_060882.2  suppressor of tumorigenicity 7 protein isoform 5

    See identical proteins and their annotated locations for NP_060882.2

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Consensus CDS
    CCDS5769.1
    UniProtKB/Swiss-Prot
    Q9NRC1
    Related
    ENSP00000377097.3, ENST00000393451.7
    Conserved Domains (1) summary
    pfam04184
    Location:19553
    ST7; ST7 protein
  11. NM_021908.3NP_068708.1  suppressor of tumorigenicity 7 protein isoform 8

    See identical proteins and their annotated locations for NP_068708.1

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC106873
    Consensus CDS
    CCDS5770.1
    UniProtKB/Swiss-Prot
    Q9NRC1
    UniProtKB/TrEMBL
    X5DRA0
    Related
    ENSP00000265437.5, ENST00000265437.9
    Conserved Domains (1) summary
    pfam04184
    Location:19546
    ST7; ST7 protein

RNA

  1. NR_161418.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873, HY033462
  2. NR_161419.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873, HY033462
  3. NR_161420.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873, HY033462
  4. NR_161421.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873, HY033462
  5. NR_161422.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
  6. NR_161423.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    116953501..117230176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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