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AGMAT agmatinase [ Homo sapiens (human) ]

Gene ID: 79814, updated on 5-Sep-2021

Summary

Official Symbol
AGMATprovided by HGNC
Official Full Name
agmatinaseprovided by HGNC
Primary source
HGNC:HGNC:18407
See related
Ensembl:ENSG00000116771 MIM:617887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in kidney (RPKM 88.3), liver (RPKM 22.6) and 5 other tissues See more
Orthologs
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Genomic context

See AGMAT in Genome Data Viewer
Location:
1p36.21
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (15571699..15585051, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (15898194..15911546, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene caspase 9 Neighboring gene DnaJ heat shock protein family (Hsp40) member C16 Neighboring gene small Cajal body-specific RNA 21B Neighboring gene RNA, U7 small nuclear 179 pseudogene Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag Depletion of the AGMAT expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23384

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables agmatinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables agmatinase activity TAS
Traceable Author Statement
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in agmatine biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in putrescine biosynthetic process from arginine, using agmatinase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
agmatinase, mitochondrial
Names
AUH
agmatine ureohydrolase (agmatinase)
NP_079034.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024758.5NP_079034.3  agmatinase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_079034.3

    Status: VALIDATED

    Source sequence(s)
    AL121992, BC005090, DN996958
    Consensus CDS
    CCDS160.1
    UniProtKB/Swiss-Prot
    Q9BSE5
    UniProtKB/TrEMBL
    A0A024QZ78
    Related
    ENSP00000364986.3, ENST00000375826.4
    Conserved Domains (1) summary
    cd11592
    Location:55343
    Agmatinase_PAH; Agmatinase-like family includes proclavaminic acid amidinohydrolase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    15571699..15585051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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