EHMT1 euchromatic histone lysine methyltransferase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: EHMT1provided by HGNC
Official Full Name: euchromatic histone lysine methyltransferase 1provided by HGNC
Primary source: HGNC:HGNC:24650
See related: Ensembl:ENSG00000181090 MIM:607001
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GLP; GLP1; KMT1D; KLEFS1; FP13812; EHMT1-IT1; EUHMTASE1; Eu-HMTase1
Summary: The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Expression: Ubiquitous expression in testis (RPKM 9.7), spleen (RPKM 7.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q34.3

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
109.20210226	current	GRCh38.p13 (GCF_000001405.39)	9	NC_000009.12 (137619001..137836127)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (140513457..140730579)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

9q34.3 microduplications lead to neurodevelopmental disorders through EHMT1 overexpression.
Title: 9q34.3 microduplications lead to neurodevelopmental disorders through EHMT1 overexpression.
Results show that EHMT1 is overexpressed in PARP inhibitors (PARPi)-resistant high-grade serous ovarian carcinoma (HGSOC) cell lines and patient-derived ascites. Combined EHMT1/2 high expression level correlates with poor patient outcomes. Knockdown or inhibition of EHMT1/2 restores PARPi sensitivity suggesting their implication in PARPi resistance.
Title: Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma.
The authors show that IFI16 is in complex with the H3K9 methyltransferase SUV39H1 and GLP and recruits them to the human herpesvirus 8 genome during de novo infection and latency. The resulting depositions of H3K9me2/me3 serve as a docking site for the heterochromatin-inducing HP1alpha protein leading into the IFI16-dependent epigenetic modifications and silencing of the virus lytic genes.
Title: IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP.
Neuronal networks of Kleefstra syndrome patient-derived cells exhibit network bursting with a reduced rate, longer duration, and increased temporal irregularity compared to control networks. We show that these changes are mediated by upregulation of NMDA receptor (NMDAR) subunit 1 correlating with reduced deposition of the repressive H3K9me2 mark, the catalytic product of EHMT1, at the GRIN1 promoter.
Title: Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.
We report infantile onset Pulmonary hypertension (PH) and congenital heart disease despite early CHD repair in three unrelated children with Kleefstra syndrome with deletions at 9q34.3 and define a 1.24 Mb critical region containing 47 protein-coding RefSeq genes including EHMT1.
Title: Pulmonary hypertension in patients with 9q34.3 microdeletion-associated Kleefstra syndrome.
G9a and GLP directly bound to the alpha subunit of HIF-1 (HIF-1alpha) and catalyzed mono- and di-methylation of HIF-1alpha. The methylation suppressed HIF-1 transcriptional activity
Title: Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration.
In summary, it was demonstrated here that the overexpression of GLP is associated with a worse prognosis in Chronic Lymphocytic Leukemia (CLL) and that the inhibition of GLP/G9a complex leads to CLL cell death. These results suggest a potential use for GLP/G9a as markers for disease progression, as well as a promising epigenetic target for CLL treatment and prevention of disease evolution.
Title: GLP overexpression is associated with poor prognosis in Chronic Lymphocytic Leukemia and its inhibition induces leukemic cell death.
High GLP expression is associated with Ovarian Cancer metastasis.
Title: FIH Is an Oxygen Sensor in Ovarian Cancer for G9a/GLP-Driven Epigenetic Regulation of Metastasis-Related Genes.
The Autism spectrum disorder candidate genes SATB2, CHD8 and EHMT1 show enriched expression in neurons, especially inhibitory neurons
Title: Enriched expression of genes associated with autism spectrum disorders in human inhibitory neurons.
Individuals with EHMT1 mosaicism seem to have increased vulnerability for developing severe psychopathology, especially ASD and mood disorders.
Title: <i>EHMT1</i> mosaicism in apparently unaffected parents is associated with autism spectrum disorder and neurocognitive dysfunction.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Kleefstra syndrome 1 MedGen: C0795833 OMIM: 610253 GeneReviews: Kleefstra Syndrome	Compare labs

Copy number response

Description
Copy number response Triplosensitivity Little evidence for dosage pathogenicity (Last evaluated 2012-07-06) ClinGen Genome Curation PagePubMed Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2012-07-06) ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH11945 (e-PCR)
- UniSTS:7732

D9S1838 (e-PCR)
- UniSTS:9019

SHGC-149365 (e-PCR)
- UniSTS:176964

RH48863 (e-PCR)
- UniSTS:70219

D10S2448 (e-PCR)
- UniSTS:474444

SHGC-82935 (e-PCR)
- UniSTS:101248

SHGC-111534 (e-PCR)
- UniSTS:168383

Homology

Homologs of the EHMT1 gene: The EHMT1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 316 organisms have orthologs with human gene EHMT1
Orthologs

Clone Names

FLJ12879, FLJ40292, FLJ46107, KIAA1876, DKFZp667M072

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
C2H2 zinc finger domain binding	IEA Inferred from Electronic Annotation more info
RNA polymerase II transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed
histone methyltransferase activity (H3-K27 specific)	ISS Inferred from Sequence or Structural Similarity more info
histone methyltransferase activity (H3-K9 specific)	ISS Inferred from Sequence or Structural Similarity more info
histone-lysine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
p53 binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein-lysine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA methylation	ISS Inferred from Sequence or Structural Similarity more info
chromatin organization	IDA Inferred from Direct Assay more info	PubMed
histone H3-K27 methylation	IEA Inferred from Electronic Annotation more info
histone H3-K9 methylation	IEA Inferred from Electronic Annotation more info
histone methylation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of G0 to G1 transition	TAS Traceable Author Statement more info
negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
negative regulation of transcription, DNA-templated	ISS Inferred from Sequence or Structural Similarity more info
peptidyl-lysine dimethylation	IDA Inferred from Direct Assay more info	PubMed
peptidyl-lysine monomethylation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
regulation of embryonic development	ISS Inferred from Sequence or Structural Similarity more info
regulation of signal transduction by p53 class mediator	TAS Traceable Author Statement more info
response to fungicide	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
chromosome	IEA Inferred from Electronic Annotation more info
nuclear body	IDA Inferred from Direct Assay more info
nucleoplasm	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IC Inferred by Curator more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase EHMT1

Names: EHMT1 intronic transcript 1; G9a-like protein 1; H3-K9-HMTase 5; euchromatic histone-lysine N-methyltransferase 1; histone H3-K9 methyltransferase 5; histone-lysine N-methyltransferase, H3 lysine-9 specific 5; lysine N-methyltransferase 1D

NP_001138999.1

EC 2.1.1.43

NP_001341188.1

EC 2.1.1.43

NP_001341192.1

EC 2.1.1.43

NP_001341540.1

EC 2.1.1.43

NP_001341541.1

EC 2.1.1.43

NP_079033.4

EC 2.1.1.43

XP_005266162.1

EC 2.1.1.43

XP_005266167.1

EC 2.1.1.43

XP_011517323.1

EC 2.1.1.43

XP_011517324.1

EC 2.1.1.43

XP_011517325.1

EC 2.1.1.43

XP_011517327.1

EC 2.1.1.43

XP_011517331.1

EC 2.1.1.43

XP_011517332.1

EC 2.1.1.43

XP_011517333.1

EC 2.1.1.43

XP_016870623.1

EC 2.1.1.43

XP_016870625.1

EC 2.1.1.43

XP_016870626.1

EC 2.1.1.43

XP_016870627.1

EC 2.1.1.43

XP_024303442.1

EC 2.1.1.43

XP_024303443.1

EC 2.1.1.43

XP_024303444.1

EC 2.1.1.43

XP_024303445.1

EC 2.1.1.43

XP_024303446.1

EC 2.1.1.43

XP_024303447.1

EC 2.1.1.43

XP_024303448.1

EC 2.1.1.43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011776.1 RefSeqGene

Range

5014..222136

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001145527.2 → NP_001138999.1 histone-lysine N-methyltransferase EHMT1 isoform 2

See identical proteins and their annotated locations for NP_001138999.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AB028932, BC047504, BM681619

Consensus CDS

CCDS56595.1

UniProtKB/Swiss-Prot

Q9H9B1

Related

ENSP00000417328.1, ENST00000462484.5

Conserved Domains (3) summary

cd00204
Location:742 → 796

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:742 → 793

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:742 → 768

ANK; ANK repeat [structural motif]
NM_001354259.2 → NP_001341188.1 histone-lysine N-methyltransferase EHMT1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an exon in the 5' region and differs in the 3' exon structure compared to variant 1. It initiates translation at a downstream start codon. The encoded isoform (3) has a shorter N-terminus and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK022941, AL590627, AL611925, BC047504

Conserved Domains (2) summary

cd00204
Location:711 → 802

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:743 → 772

ANK; ANK repeat [structural motif]
NM_001354263.2 → NP_001341192.1 histone-lysine N-methyltransferase EHMT1 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice site compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AL365502, AL590627, AL611925

Conserved Domains (5) summary

smart00317
Location:1119 → 1241

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:793 → 919

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:798 → 829

ANK; ANK repeat [structural motif]

pfam05033
Location:1007 → 1111

Pre-SET; Pre-SET motif

cl26073
Location:740 → 999

Ank_2; Ankyrin repeats (3 copies)
NM_001354611.2 → NP_001341540.1 histone-lysine N-methyltransferase EHMT1 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks multiple 3' exons and contains an alternate 3' coding region and 3' UTR compared to variant 1. The encoded isoform (5) has a shorter, distinct C-terminus compared to isoform 1.

Source sequence(s)

AL365502, AL590627

Consensus CDS

CCDS87721.1

Related

ENSP00000490056.1, ENST00000629335.2
NM_001354612.2 → NP_001341541.1 histone-lysine N-methyltransferase EHMT1 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an exon in the 5' region, initiates translation at a downstream start codon and differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (6) has a shorter N-terminus and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL365502, AL590627

Related

ENSP00000485900.1, ENST00000626066.2
NM_024757.5 → NP_079033.4 histone-lysine N-methyltransferase EHMT1 isoform 1

See identical proteins and their annotated locations for NP_079033.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AB028932, BC011608, BC047504, CA426038

Consensus CDS

CCDS7050.2

UniProtKB/Swiss-Prot

Q9H9B1

Related

ENSP00000417980.1, ENST00000460843.6

Conserved Domains (6) summary

smart00248
Location:772 → 800

ANK; ankyrin repeats

smart00317
Location:1126 → 1248

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:800 → 926

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam05033
Location:1014 → 1118

Pre-SET; Pre-SET motif

pfam12796
Location:810 → 903

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:805 → 836

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p13 Primary Assembly

Range

137619001..137836127

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017015136.2 → XP_016870625.1 histone-lysine N-methyltransferase EHMT1 isoform X8
XM_005266110.1 → XP_005266167.1 histone-lysine N-methyltransferase EHMT1 isoform X7

See identical proteins and their annotated locations for XP_005266167.1

UniProtKB/TrEMBL

A0A1B0GV09

Conserved Domains (6) summary

smart00248
Location:741 → 769

ANK; ankyrin repeats

smart00317
Location:1095 → 1217

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:769 → 895

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam05033
Location:983 → 1087

Pre-SET; Pre-SET motif

pfam12796
Location:779 → 872

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:774 → 805

ANK; ANK repeat [structural motif]
XM_017015138.1 → XP_016870627.1 histone-lysine N-methyltransferase EHMT1 isoform X9
XM_011519022.3 → XP_011517324.1 histone-lysine N-methyltransferase EHMT1 isoform X2

Conserved Domains (6) summary

smart00248
Location:774 → 802

ANK; ankyrin repeats

smart00317
Location:1128 → 1250

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:802 → 928

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam05033
Location:1016 → 1120

Pre-SET; Pre-SET motif

pfam12796
Location:812 → 905

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:807 → 838

ANK; ANK repeat [structural motif]
XM_017015134.1 → XP_016870623.1 histone-lysine N-methyltransferase EHMT1 isoform X5
XM_005266105.5 → XP_005266162.1 histone-lysine N-methyltransferase EHMT1 isoform X3

Conserved Domains (6) summary

smart00248
Location:769 → 797

ANK; ankyrin repeats

smart00317
Location:1123 → 1245

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:797 → 923

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam05033
Location:1011 → 1115

Pre-SET; Pre-SET motif

pfam12796
Location:807 → 900

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:802 → 833

ANK; ANK repeat [structural motif]
XM_011519021.3 → XP_011517323.1 histone-lysine N-methyltransferase EHMT1 isoform X1

Conserved Domains (6) summary

smart00248
Location:775 → 803

ANK; ankyrin repeats

smart00317
Location:1129 → 1251

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:803 → 929

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam05033
Location:1017 → 1121

Pre-SET; Pre-SET motif

pfam12796
Location:813 → 906

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:808 → 839

ANK; ANK repeat [structural motif]
XM_011519023.3 → XP_011517325.1 histone-lysine N-methyltransferase EHMT1 isoform X4

Conserved Domains (6) summary

smart00248
Location:768 → 796

ANK; ankyrin repeats

smart00317
Location:1122 → 1244

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:796 → 922

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam05033
Location:1010 → 1114

Pre-SET; Pre-SET motif

pfam12796
Location:806 → 899

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:801 → 832

ANK; ANK repeat [structural motif]
XM_011519025.1 → XP_011517327.1 histone-lysine N-methyltransferase EHMT1 isoform X7

See identical proteins and their annotated locations for XP_011517327.1

UniProtKB/TrEMBL

A0A1B0GV09

Related

ENSP00000490328.1, ENST00000637161.1

Conserved Domains (6) summary

smart00248
Location:741 → 769

ANK; ankyrin repeats

smart00317
Location:1095 → 1217

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:769 → 895

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam05033
Location:983 → 1087

Pre-SET; Pre-SET motif

pfam12796
Location:779 → 872

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:774 → 805

ANK; ANK repeat [structural motif]
XM_017015137.1 → XP_016870626.1 histone-lysine N-methyltransferase EHMT1 isoform X9
XM_024447675.1 → XP_024303443.1 histone-lysine N-methyltransferase EHMT1 isoform X10

Conserved Domains (5) summary

smart00317
Location:1047 → 1169

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:721 → 847

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:726 → 757

ANK; ANK repeat [structural motif]

pfam05033
Location:935 → 1039

Pre-SET; Pre-SET motif

pfam12796
Location:663 → 757

Ank_2; Ankyrin repeats (3 copies)
XM_024447674.1 → XP_024303442.1 histone-lysine N-methyltransferase EHMT1 isoform X6

Conserved Domains (5) summary

smart00317
Location:1069 → 1191

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:743 → 869

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:748 → 779

ANK; ANK repeat [structural motif]

pfam05033
Location:957 → 1061

Pre-SET; Pre-SET motif

pfam12796
Location:685 → 779

Ank_2; Ankyrin repeats (3 copies)
XM_024447680.1 → XP_024303448.1 histone-lysine N-methyltransferase EHMT1 isoform X17

Conserved Domains (5) summary

smart00317
Location:1040 → 1162

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:714 → 840

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:719 → 750

ANK; ANK repeat [structural motif]

pfam05033
Location:928 → 1032

Pre-SET; Pre-SET motif

pfam12796
Location:656 → 750

Ank_2; Ankyrin repeats (3 copies)
XM_024447678.1 → XP_024303446.1 histone-lysine N-methyltransferase EHMT1 isoform X12

Related

ENSP00000489961.1, ENST00000636027.1

Conserved Domains (3) summary

cd00204
Location:741 → 862

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:774 → 805

ANK; ANK repeat [structural motif]

cl02529
Location:711 → 762

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
XM_024447679.1 → XP_024303447.1 histone-lysine N-methyltransferase EHMT1 isoform X13

Conserved Domains (2) summary

sd00045
Location:711 → 737

ANK; ANK repeat [structural motif]

pfam12796
Location:711 → 763

Ank_2; Ankyrin repeats (3 copies)
XM_024447676.1 → XP_024303444.1 histone-lysine N-methyltransferase EHMT1 isoform X11

Conserved Domains (5) summary

smart00317
Location:834 → 956

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:508 → 634

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:513 → 544

ANK; ANK repeat [structural motif]

pfam05033
Location:722 → 826

Pre-SET; Pre-SET motif

pfam12796
Location:450 → 544

Ank_2; Ankyrin repeats (3 copies)
XM_024447677.1 → XP_024303445.1 histone-lysine N-methyltransferase EHMT1 isoform X11

Conserved Domains (5) summary

smart00317
Location:834 → 956

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:508 → 634

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:513 → 544

ANK; ANK repeat [structural motif]

pfam05033
Location:722 → 826

Pre-SET; Pre-SET motif

pfam12796
Location:450 → 544

Ank_2; Ankyrin repeats (3 copies)
XM_011519029.3 → XP_011517331.1 histone-lysine N-methyltransferase EHMT1 isoform X14

Conserved Domains (6) summary

smart00248
Location:249 → 277

ANK; ankyrin repeats

smart00317
Location:603 → 725

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:277 → 403

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam05033
Location:491 → 595

Pre-SET; Pre-SET motif

pfam12796
Location:287 → 380

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:282 → 313

ANK; ANK repeat [structural motif]
XM_011519030.3 → XP_011517332.1 histone-lysine N-methyltransferase EHMT1 isoform X15

Conserved Domains (7) summary

smart00248
Location:199 → 228

ANK; ankyrin repeats

smart00317
Location:387 → 509

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:61 → 187

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam05033
Location:275 → 379

Pre-SET; Pre-SET motif

pfam12796
Location:71 → 164

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:54 → 87

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:66 → 97

ANK; ANK repeat [structural motif]
XM_011519031.1 → XP_011517333.1 histone-lysine N-methyltransferase EHMT1 isoform X16

See identical proteins and their annotated locations for XP_011517333.1

Conserved Domains (5) summary

smart00317
Location:316 → 438

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:23 → 149

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam05033
Location:204 → 308

Pre-SET; Pre-SET motif

pfam12796
Location:1 → 93

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:28 → 60

ANK; ANK repeat [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001039765.1: Suppressed sequence

Description

NM_001039765.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.