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GSTCD glutathione S-transferase C-terminal domain containing [ Homo sapiens (human) ]

Gene ID: 79807, updated on 11-Jun-2021

Summary

Official Symbol
GSTCDprovided by HGNC
Official Full Name
glutathione S-transferase C-terminal domain containingprovided by HGNC
Primary source
HGNC:HGNC:25806
See related
Ensembl:ENSG00000138780 MIM:615912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.2) and 25 other tissues See more
Orthologs
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Genomic context

See GSTCD in Genome Data Viewer
Location:
4q24
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (105708778..105847726)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (106629941..106768882)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ARHGEF38 intronic transcript 1 Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene integrator complex subunit 12 Neighboring gene uncharacterized LOC107986190 Neighboring gene GSTCD antisense RNA 1 Neighboring gene nephronectin Neighboring gene uncharacterized LOC101929577

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Gene network analysis in a pediatric cohort identifies novel lung function genes.
GeneReviews: Not available
Genome-wide association study identifies five loci associated with lung function.
GeneReviews: Not available
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
GeneReviews: Not available
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13273, DKFZp686I10174

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
glutathione S-transferase C-terminal domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031720.3NP_001026890.2  glutathione S-transferase C-terminal domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001026890.2

    Status: VALIDATED

    Source sequence(s)
    AC008243, AK292355, BC032942
    Consensus CDS
    CCDS43257.1
    UniProtKB/Swiss-Prot
    Q8NEC7
    Related
    ENSP00000353695.5, ENST00000360505.9
    Conserved Domains (2) summary
    cl02776
    Location:270329
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:423541
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001370181.1NP_001357110.1  glutathione S-transferase C-terminal domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008243, AC105391
    Related
    ENSP00000422354.1, ENST00000515279.6
    Conserved Domains (2) summary
    cl02776
    Location:270329
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:423541
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_024751.3NP_079027.2  glutathione S-transferase C-terminal domain-containing protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008243, AK303547, BC032942, BX648355
    Consensus CDS
    CCDS3672.2
    UniProtKB/Swiss-Prot
    Q8NEC7
    UniProtKB/TrEMBL
    B7Z8J7
    Related
    ENSP00000378218.3, ENST00000394730.7
    Conserved Domains (2) summary
    cl02776
    Location:186242
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:336454
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    105708778..105847726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532252.3XP_011530554.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011530554.1

    UniProtKB/Swiss-Prot
    Q8NEC7
    Conserved Domains (2) summary
    cl02776
    Location:270329
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:423541
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_011532249.3XP_011530551.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011530551.1

    UniProtKB/Swiss-Prot
    Q8NEC7
    Conserved Domains (2) summary
    cl02776
    Location:270329
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:423541
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_011532248.3XP_011530550.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011530550.1

    UniProtKB/Swiss-Prot
    Q8NEC7
    Conserved Domains (2) summary
    cl02776
    Location:270329
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:423541
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. XR_938771.1 RNA Sequence

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