Format

Send to:

Choose Destination

UGT2A3 UDP glucuronosyltransferase family 2 member A3 [ Homo sapiens (human) ]

Gene ID: 79799, updated on 21-Dec-2019

Summary

Official Symbol
UGT2A3provided by HGNC
Official Full Name
UDP glucuronosyltransferase family 2 member A3provided by HGNC
Primary source
HGNC:HGNC:28528
See related
Ensembl:ENSG00000135220 MIM:616382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in duodenum (RPKM 93.7), small intestine (RPKM 88.2) and 5 other tissues See more
Orthologs

Genomic context

See UGT2A3 in Genome Data Viewer
Location:
4q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (68928460..68951804, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (69794177..69817509, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP-glucuronosyltransferase 2B10-like Neighboring gene speckle type BTB/POZ protein like pseudogene Neighboring gene UDP-glucuronosyltransferase 2B10-like Neighboring gene UDP glucuronosyltransferase family 2 member A1 complex locus pseudogene Neighboring gene speckle type BTB/POZ protein like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21934

Gene Ontology Provided by GOA

Function Evidence Code Pubs
UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular glucuronidation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
UDP-glucuronosyltransferase 2A3
Names
UDP glucuronosyltransferase 2 family, polypeptide A3
UDPGT 2A3
NP_079019.3
XP_011530549.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024743.4NP_079019.3  UDP-glucuronosyltransferase 2A3 precursor

    See identical proteins and their annotated locations for NP_079019.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript.
    Source sequence(s)
    AC021146, AK025587, AY542891
    Consensus CDS
    CCDS3525.1
    UniProtKB/Swiss-Prot
    Q6UWM9
    Related
    ENSP00000251566.4, ENST00000251566.9
    Conserved Domains (2) summary
    PHA03392
    Location:267492
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:24522
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RNA

  1. NR_024010.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon in the coding region, compared to variant 1, which results in the introduction of an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC021146, AK025587, AY542891, BP262099

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    68928460..68951804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532247.2XP_011530549.1  UDP-glucuronosyltransferase 2A3 isoform X1

    See identical proteins and their annotated locations for XP_011530549.1

    Conserved Domains (2) summary
    PHA03392
    Location:267498
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:24528
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167250.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    504482..527823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center