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CLMN calmin [ Homo sapiens (human) ]

Gene ID: 79789, updated on 12-Oct-2019

Summary

Official Symbol
CLMNprovided by HGNC
Official Full Name
calminprovided by HGNC
Primary source
HGNC:HGNC:19972
See related
Ensembl:ENSG00000165959 MIM:611121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 7.5), kidney (RPKM 7.3) and 25 other tissues See more
Orthologs

Genomic context

See CLMN in Genome Data Viewer
Location:
14q32.13
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (95181940..95319908, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95648276..95786245, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene dicer 1, ribonuclease III Neighboring gene microRNA 3173 Neighboring gene DICER1 antisense RNA 1 Neighboring gene uncharacterized LOC105370637 Neighboring gene long intergenic non-protein coding RNA 2292

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variants associated with breast size also influence breast cancer risk.
NHGRI GWA Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
NHGRI GWA Catalog
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of calmin (CLMN) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12383, FLJ43048, KIAA0500, KIAA1188

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cytoskeletal anchoring at nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection development IEA
Inferred from Electronic Annotation
more info
 
nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calmin
Names
calmin (calponin-like, transmembrane)
calponin-like transmembrane domain protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024734.4NP_079010.2  calmin

    See identical proteins and their annotated locations for NP_079010.2

    Status: VALIDATED

    Source sequence(s)
    AB007969, AB047979, AL356017, BC068482, CB155696
    Consensus CDS
    CCDS9933.1
    UniProtKB/Swiss-Prot
    Q96JQ2
    UniProtKB/TrEMBL
    Q6NUQ2
    Related
    ENSP00000298912.3, ENST00000298912.9
    Conserved Domains (1) summary
    pfam00307
    Location:33134
    CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    95181940..95319908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537158.1XP_011535460.1  calmin isoform X1

    Conserved Domains (1) summary
    pfam00307
    Location:33134
    CH; Calponin homology (CH) domain
  2. XM_017021646.1XP_016877135.1  calmin isoform X2

  3. XM_011537159.2XP_011535461.1  calmin isoform X4

    Conserved Domains (1) summary
    pfam00307
    Location:33134
    CH; Calponin homology (CH) domain
  4. XM_017021647.1XP_016877136.1  calmin isoform X3

RNA

  1. XR_429332.2 RNA Sequence

  2. XR_429330.2 RNA Sequence

  3. XR_245721.2 RNA Sequence

  4. XR_001750558.1 RNA Sequence

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