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KLHL36 kelch like family member 36 [ Homo sapiens (human) ]

Gene ID: 79786, updated on 11-Sep-2019

Summary

Official Symbol
KLHL36provided by HGNC
Official Full Name
kelch like family member 36provided by HGNC
Primary source
HGNC:HGNC:17844
See related
Ensembl:ENSG00000135686
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C16orf44
Expression
Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See KLHL36 in Genome Data Viewer
Location:
16q24.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (84648511..84667686)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (84682131..84701187)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MTOR associated protein, eak-7 homolog Neighboring gene coactosin like F-actin binding protein 1 Neighboring gene uncharacterized LOC105371376 Neighboring gene ubiquitin specific peptidase 10 Neighboring gene uncharacterized LOC105371378

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12543

Gene Ontology Provided by GOA

Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kelch-like protein 36
Names
kelch-like 36

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303451.2NP_001290380.1  kelch-like protein 36 isoform 2

    See identical proteins and their annotated locations for NP_001290380.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC009116, AW337439, BC032400, DA049618
    Consensus CDS
    CCDS76909.1
    UniProtKB/Swiss-Prot
    Q8N4N3
    Related
    ENSP00000258157.5, ENST00000258157.9
    Conserved Domains (2) summary
    sd00038
    Location:372416
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:45522
    BTB; Broad-Complex, Tramtrack and Bric a brac
  2. NM_024731.4NP_079007.2  kelch-like protein 36 isoform 1

    See identical proteins and their annotated locations for NP_079007.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC009116, AK022605, AW337439, BC033821, DA049618
    Consensus CDS
    CCDS10948.1
    UniProtKB/Swiss-Prot
    Q8N4N3
    Related
    ENSP00000456743.1, ENST00000564996.6
    Conserved Domains (6) summary
    smart00612
    Location:547593
    Kelch; Kelch domain
    PHA03098
    Location:45585
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:335383
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:36139
    BTB; BTB/POZ domain
    pfam01344
    Location:386431
    Kelch_1; Kelch motif
    pfam07707
    Location:149250
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    84648511..84667686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256149.2XP_005256206.1  kelch-like protein 36 isoform X1

    See identical proteins and their annotated locations for XP_005256206.1

    UniProtKB/Swiss-Prot
    Q8N4N3
    Conserved Domains (6) summary
    smart00612
    Location:547593
    Kelch; Kelch domain
    PHA03098
    Location:45585
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:335383
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:36139
    BTB; BTB/POZ domain
    pfam01344
    Location:386431
    Kelch_1; Kelch motif
    pfam07707
    Location:149250
    BACK; BTB And C-terminal Kelch

RNA

  1. XR_933433.3 RNA Sequence

  2. XR_001751986.2 RNA Sequence

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