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SUGCT succinyl-CoA:glutarate-CoA transferase [ Homo sapiens (human) ]

Gene ID: 79783, updated on 31-Oct-2022

Summary

Official Symbol
SUGCTprovided by HGNC
Official Full Name
succinyl-CoA:glutarate-CoA transferaseprovided by HGNC
Primary source
HGNC:HGNC:16001
See related
Ensembl:ENSG00000175600 MIM:609187; AllianceGenome:HGNC:16001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GA3; ORF19; DERP13; C7orf10
Summary
This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Expression
Biased expression in kidney (RPKM 3.4), liver (RPKM 1.2) and 12 other tissues See more
Orthologs
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Genomic context

See SUGCT in Genome Data Viewer
Location:
7p14.1
Exon count:
24
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (40135005..41038816)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (40292462..41018559)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (40174604..40900362)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 7 Neighboring gene THUMP domain containing 3 pseudogene 1 Neighboring gene M-phase specific PLK1 interacting protein Neighboring gene uncharacterized LOC105375245 Neighboring gene Sharpr-MPRA regulatory region 14136 Neighboring gene uncharacterized LOC105375244 Neighboring gene SUGCT antisense RNA 1 Neighboring gene uncharacterized LOC105375243 Neighboring gene uncharacterized LOC112267984 Neighboring gene uncharacterized LOC105375242 Neighboring gene long intergenic non-protein coding RNA 1450 Neighboring gene Sharpr-MPRA regulatory region 15680 Neighboring gene uncharacterized LOC105375241 Neighboring gene long intergenic non-protein coding RNA 1449

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Glutaryl-CoA oxidase deficiency
MedGen: C0342873 OMIM: 231690 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11808, FLJ53872

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables succinate-hydroxymethylglutarate CoA-transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
succinate--hydroxymethylglutarate CoA-transferase
Names
Russel-Silver syndrome candidate
dermal papilla-derived protein 13
succinylCoA:glutarate-CoA transferase
NP_001180240.2
NP_001180241.2
NP_001180242.2
NP_079004.2
XP_006715838.2
XP_011513827.2
XP_011513828.1
XP_011513829.2
XP_011513831.2
XP_011513832.2
XP_016868110.1
XP_016868111.2
XP_047276796.1
XP_047276797.1
XP_047276798.1
XP_047276799.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023422.3 RefSeqGene

    Range
    5002..730760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193311.2NP_001180240.2  succinate--hydroxymethylglutarate CoA-transferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC005160, AK296048, BC098318
    Consensus CDS
    CCDS55104.2
    Related
    ENSP00000486291.2, ENST00000628514.3
    Conserved Domains (1) summary
    COG1804
    Location:39458
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]
  2. NM_001193312.2NP_001180241.2  succinate--hydroxymethylglutarate CoA-transferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC005160, BC098310
    Consensus CDS
    CCDS55106.2
    Related
    ENSP00000385222.3, ENST00000401647.7
    Conserved Domains (1) summary
    COG1804
    Location:39384
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]
  3. NM_001193313.2NP_001180242.2  succinate--hydroxymethylglutarate CoA-transferase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC005160, AK021870, AK296048
    Consensus CDS
    CCDS55105.2
    UniProtKB/TrEMBL
    B4DJF0
    Related
    ENSP00000338475.5, ENST00000335693.9
    Conserved Domains (1) summary
    COG1804
    Location:39432
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]
  4. NM_024728.3NP_079004.2  succinate--hydroxymethylglutarate CoA-transferase isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AC005160, AK021870, AK299133
    Conserved Domains (1) summary
    COG1804
    Location:39421
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    40135005..41038816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420840.1XP_047276796.1  succinate--hydroxymethylglutarate CoA-transferase isoform X4

  2. XM_047420843.1XP_047276799.1  succinate--hydroxymethylglutarate CoA-transferase isoform X11

  3. XM_011515525.4XP_011513827.2  succinate--hydroxymethylglutarate CoA-transferase isoform X1

  4. XM_006715775.4XP_006715838.2  succinate--hydroxymethylglutarate CoA-transferase isoform X2

  5. XM_011515527.4XP_011513829.2  succinate--hydroxymethylglutarate CoA-transferase isoform X6

  6. XM_011515529.4XP_011513831.2  succinate--hydroxymethylglutarate CoA-transferase isoform X9

  7. XM_047420841.1XP_047276797.1  succinate--hydroxymethylglutarate CoA-transferase isoform X8

  8. XM_017012622.3XP_016868111.2  succinate--hydroxymethylglutarate CoA-transferase isoform X7

  9. XM_011515530.4XP_011513832.2  succinate--hydroxymethylglutarate CoA-transferase isoform X12

  10. XM_047420842.1XP_047276798.1  succinate--hydroxymethylglutarate CoA-transferase isoform X10

  11. XM_011515526.2XP_011513828.1  succinate--hydroxymethylglutarate CoA-transferase isoform X3

    Conserved Domains (1) summary
    COG1804
    Location:20465
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]
  12. XM_017012621.1XP_016868110.1  succinate--hydroxymethylglutarate CoA-transferase isoform X5

RNA

  1. XR_007060157.1 RNA Sequence

  2. XR_007060158.1 RNA Sequence

  3. XR_007060156.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    40292462..41018559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)