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LRRC31 leucine rich repeat containing 31 [ Homo sapiens (human) ]

Gene ID: 79782, updated on 23-Nov-2021

Summary

Official Symbol
LRRC31provided by HGNC
Official Full Name
leucine rich repeat containing 31provided by HGNC
Primary source
HGNC:HGNC:26261
See related
Ensembl:ENSG00000114248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL-S-293
Expression
Biased expression in colon (RPKM 8.8), small intestine (RPKM 3.9) and 4 other tissues See more
Orthologs
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Genomic context

See LRRC31 in Genome Data Viewer
Location:
3q26.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (169839172..169869935, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (169556960..169587723, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7912 Neighboring gene myoneurin Neighboring gene leucine rich repeat containing 34 Neighboring gene leucine rich repeats and IQ motif containing 4 Neighboring gene keratin 18 pseudogene 43 Neighboring gene sterile alpha motif domain containing 7 Neighboring gene FAM20B, glycosaminoglycan xylosylkinase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23259, FLJ40019

General protein information

Preferred Names
leucine-rich repeat-containing protein 31
Names
epididymis secretory protein Li 293
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277127.2NP_001264056.1  leucine-rich repeat-containing protein 31 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK026912, BC143582, DA425899
    Consensus CDS
    CCDS63833.1
    UniProtKB/Swiss-Prot
    Q6UY01
    Related
    ENSP00000429145.1, ENST00000523069.1
    Conserved Domains (3) summary
    cd00116
    Location:91349
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:116143
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:89115
    LRR_AMN1; leucine-rich repeat [structural motif]
  2. NM_001277128.2NP_001264057.1  leucine-rich repeat-containing protein 31 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC078795, AK026912, BC117401, DA425899
    Consensus CDS
    CCDS63832.1
    UniProtKB/Swiss-Prot
    Q6UY01
    Related
    ENSP00000264676.5, ENST00000264676.9
    Conserved Domains (2) summary
    cd00116
    Location:164433
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:91115
    LRR_RI; leucine-rich repeat [structural motif]
  3. NM_024727.4NP_079003.2  leucine-rich repeat-containing protein 31 isoform 1

    See identical proteins and their annotated locations for NP_079003.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC078795, AK026912, BC117401, DA425899
    Consensus CDS
    CCDS43167.1
    UniProtKB/Swiss-Prot
    Q6UY01
    Related
    ENSP00000325978.5, ENST00000316428.10
    Conserved Domains (2) summary
    sd00033
    Location:116143
    LRR_RI; leucine-rich repeat [structural motif]
    cl26161
    Location:91349
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    169839172..169869935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513159.2XP_011511461.1  leucine-rich repeat-containing protein 31 isoform X2

    Conserved Domains (2) summary
    cd00116
    Location:135407
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:116143
    LRR_RI; leucine-rich repeat [structural motif]
  2. XM_011513158.2XP_011511460.1  leucine-rich repeat-containing protein 31 isoform X1

    Conserved Domains (2) summary
    cd00116
    Location:91349
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:116143
    LRR_RI; leucine-rich repeat [structural motif]
  3. XM_017007204.1XP_016862693.1  leucine-rich repeat-containing protein 31 isoform X3

  4. XM_011513160.3XP_011511462.1  leucine-rich repeat-containing protein 31 isoform X4

    See identical proteins and their annotated locations for XP_011511462.1

    UniProtKB/Swiss-Prot
    Q6UY01
    Conserved Domains (2) summary
    cd00116
    Location:91335
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:89115
    LRR_AMN1; leucine-rich repeat [structural motif]
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