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MTERF1 mitochondrial transcription termination factor 1 [ Homo sapiens (human) ]

Gene ID: 7978, updated on 9-Jan-2019

Summary

Official Symbol
MTERF1provided by HGNC
Official Full Name
mitochondrial transcription termination factor 1provided by HGNC
Primary source
HGNC:HGNC:21463
See related
Ensembl:ENSG00000127989 MIM:602318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTERF
Summary
This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 5.6), appendix (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See MTERF1 in Genome Data Viewer
Location:
7q21.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (91872876..91880733, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (91502021..91510016, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375392 Neighboring gene uncharacterized LOC107986716 Neighboring gene uncharacterized LOC101927473 Neighboring gene uncharacterized LOC112267986 Neighboring gene A-kinase anchoring protein 9 Neighboring gene CYP51A1 antisense RNA 1 Neighboring gene cytochrome P450 family 51 subfamily A member 1 Neighboring gene leucine rich repeats and death domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131634

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA geometric change IDA
Inferred from Direct Assay
more info
PubMed 
DNA-templated transcription, termination IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion organization TAS
Traceable Author Statement
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
termination of mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
termination of mitochondrial transcription IDA
Inferred from Direct Assay
more info
PubMed 
termination of mitochondrial transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
transcription termination factor 1, mitochondrial
Names
transcription termination factor, mitochondrial

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301134.1NP_001288063.1  transcription termination factor 1, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001288063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK222730, AL832861, BC130391, BU740531
    Consensus CDS
    CCDS75629.1
    UniProtKB/Swiss-Prot
    Q99551
    UniProtKB/TrEMBL
    B4DPR9
    Related
    ENSP00000414116.1, ENST00000419292.1
    Conserved Domains (1) summary
    pfam02536
    Location:56369
    mTERF; mTERF
  2. NM_001301135.1NP_001288064.1  transcription termination factor 1, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001288064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK222730, AK298469, BU740531
    Consensus CDS
    CCDS75629.1
    UniProtKB/Swiss-Prot
    Q99551
    UniProtKB/TrEMBL
    B4DPR9
    Related
    ENSP00000384986.2, ENST00000406735.6
    Conserved Domains (1) summary
    pfam02536
    Location:56369
    mTERF; mTERF
  3. NM_006980.4NP_008911.1  transcription termination factor 1, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_008911.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK222730, BC130391, BU740531
    Consensus CDS
    CCDS5621.1
    UniProtKB/Swiss-Prot
    Q99551
    Related
    ENSP00000248643.3, ENST00000351870.7
    Conserved Domains (1) summary
    pfam02536
    Location:76389
    mTERF; mTERF

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    91872876..91880733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012620.1XP_016868109.1  transcription termination factor 1, mitochondrial isoform X2

    UniProtKB/TrEMBL
    B4DPR9
    Conserved Domains (1) summary
    pfam02536
    Location:56369
    mTERF; mTERF
  2. XM_006716126.3XP_006716189.1  transcription termination factor 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006716189.1

    UniProtKB/Swiss-Prot
    Q99551
    Conserved Domains (1) summary
    pfam02536
    Location:76389
    mTERF; mTERF
  3. XM_005250593.3XP_005250650.1  transcription termination factor 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005250650.1

    UniProtKB/Swiss-Prot
    Q99551
    Conserved Domains (1) summary
    pfam02536
    Location:76389
    mTERF; mTERF
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