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MICALL2 MICAL like 2 [ Homo sapiens (human) ]

Gene ID: 79778, updated on 10-Oct-2023

Summary

Official Symbol
MICALL2provided by HGNC
Official Full Name
MICAL like 2provided by HGNC
Primary source
HGNC:HGNC:29672
See related
Ensembl:ENSG00000164877 AllianceGenome:HGNC:29672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JRAB; MICAL-L2
Summary
Enables filamin binding activity. Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in several cellular components, including bicellular tight junction; neuron projection; and recycling endosome. Predicted to colocalize with stress fiber. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 13.4), small intestine (RPKM 10.9) and 23 other tissues See more
Orthologs
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Genomic context

See MICALL2 in Genome Data Viewer
Location:
7p22.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (1434359..1459470, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (1545546..1571603, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1473995..1499106, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene hESC enhancers GRCh37_chr7:1199449-1199961 and GRCh37_chr7:1199962-1200475 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1200476-1200988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1209085-1210060 Neighboring gene ZFAND2A divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1210061-1211034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17848 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:1220431-1221630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1232959-1233460 Neighboring gene Sharpr-MPRA regulatory region 5475 Neighboring gene VISTA enhancer hs293 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1273513-1274057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1274230-1275058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1281290-1282188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1288405-1288950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1294047-1294547 Neighboring gene MPRA-validated peak6338 silencer Neighboring gene UNC homeobox Neighboring gene MS31A repeat instability region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1329612-1330486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1341047-1341548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1360639-1361139 Neighboring gene MPRA-validated peak6340 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1409793-1410317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17851 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1458534-1459206 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1459207-1459877 Neighboring gene Sharpr-MPRA regulatory region 11952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1468179-1468734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1486489-1486993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1491449-1492000 Neighboring gene Sharpr-MPRA regulatory region 3173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1497060-1497782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1497783-1498505 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1499929-1500480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1500481-1501032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1505291-1505986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1505987-1506682 Neighboring gene MICALL2 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1509467-1510162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1533403-1533903 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17854 Neighboring gene integrator complex subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ23471, FLJ41996, FLJ44858, FLJ45410, MGC46023

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables actinin binding IEA
Inferred from Electronic Annotation
more info
 
enables filamin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in bicellular tight junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endocytic recycling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
involved_in substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
colocalizes_with actin filament bundle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with stress fiber ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
MICAL-like protein 2
Names
junctional Rab13-binding protein
molecule interacting with CasL-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182924.4NP_891554.1  MICAL-like protein 2

    See identical proteins and their annotated locations for NP_891554.1

    Status: VALIDATED

    Source sequence(s)
    AK027124, AK074068, AY358755, BC037988, DA945802
    Consensus CDS
    CCDS5324.1
    UniProtKB/Swiss-Prot
    D3YTD2, Q7RTP4, Q7Z655, Q8IY33, Q8TEQ4, Q9H5F9
    Related
    ENSP00000297508.7, ENST00000297508.8
    Conserved Domains (4) summary
    cd09444
    Location:188241
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    pfam00307
    Location:5102
    CH; Calponin homology (CH) domain
    pfam12130
    Location:736872
    DUF3585; Protein of unknown function (DUF3585)
    pfam12325
    Location:784879
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    1434359..1459470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420838.1XP_047276794.1  MICAL-like protein 2 isoform X3

  2. XM_047420836.1XP_047276792.1  MICAL-like protein 2 isoform X1

  3. XM_047420837.1XP_047276793.1  MICAL-like protein 2 isoform X2

    Related
    ENSP00000405415.1, ENST00000413446.5

RNA

  1. XR_002956487.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    1545546..1571603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359005.1XP_054214980.1  MICAL-like protein 2 isoform X3

  2. XM_054359004.1XP_054214979.1  MICAL-like protein 2 isoform X1

RNA

  1. XR_008487754.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024723.1: Suppressed sequence

    Description
    NM_024723.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.