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ZFHX4 zinc finger homeobox 4 [ Homo sapiens (human) ]

Gene ID: 79776, updated on 17-Jun-2024

Summary

Official Symbol
ZFHX4provided by HGNC
Official Full Name
zinc finger homeobox 4provided by HGNC
Primary source
HGNC:HGNC:30939
See related
Ensembl:ENSG00000091656 MIM:606940; AllianceGenome:HGNC:30939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFH4; ZHF4
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 2.1), adrenal (RPKM 2.1) and 16 other tissues See more
Orthologs
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Genomic context

See ZFHX4 in Genome Data Viewer
Location:
8q21.13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (76681247..76867281)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (77110392..77296418)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (77593482..77779517)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1111 Neighboring gene uncharacterized LOC107986952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27544 Neighboring gene ZFHX4 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr8:77553488-77553989 Neighboring gene mitochondrial ribosomal protein L9 pseudogene 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:77585153-77585653 Neighboring gene Sharpr-MPRA regulatory region 233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19304 Neighboring gene VISTA enhancer hs1318 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:77676670-77677613 Neighboring gene VISTA enhancer hs774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19305 Neighboring gene VISTA enhancer hs1681 Neighboring gene Sharpr-MPRA regulatory region 11833 Neighboring gene microRNA 3149 Neighboring gene peroxisomal biogenesis factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Ptosis, hereditary congenital, 1
MedGen: C1867438 OMIM: 178300 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome wide association study of age at menarche in the Japanese population.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ16514, FLJ20980

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
zinc finger homeobox protein 4
Names
zinc-finger homeodomain protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410934.1NP_001397863.1  zinc finger homeobox protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC011716, AC023200, AC087110
    Consensus CDS
    CCDS94320.1
    UniProtKB/Swiss-Prot
    G3V138, Q18PS0, Q6ZN20, Q86UP3
    UniProtKB/TrEMBL
    E7EVZ1
    Related
    ENSP00000430848.1, ENST00000518282.5
  2. NM_024721.5NP_078997.4  zinc finger homeobox protein 4 isoform 1

    See identical proteins and their annotated locations for NP_078997.4

    Status: VALIDATED

    Source sequence(s)
    AB083343, AC011716, AC023200, AC087110, CA430749, DA658176
    Consensus CDS
    CCDS47878.2
    UniProtKB/Swiss-Prot
    G3V138, Q18PS0, Q6ZN20, Q86UP3
    Related
    ENSP00000498627.1, ENST00000651372.2
    Conserved Domains (6) summary
    PHA02682
    Location:23502506
    PHA02682; ORF080 virion core protein; Provisional
    smart00389
    Location:21302185
    HOX; Homeodomain
    COG5576
    Location:21012240
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:15431567
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:13991419
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:22292282
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    76681247..76867281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    77110392..77296418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)