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GRTP1 growth hormone regulated TBC protein 1 [ Homo sapiens (human) ]

Gene ID: 79774, updated on 1-Jun-2020

Summary

Official Symbol
GRTP1provided by HGNC
Official Full Name
growth hormone regulated TBC protein 1provided by HGNC
Primary source
HGNC:HGNC:20310
See related
Ensembl:ENSG00000139835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TBC1D6
Expression
Broad expression in duodenum (RPKM 6.6), small intestine (RPKM 5.5) and 19 other tissues See more
Orthologs

Genomic context

See GRTP1 in Genome Data Viewer
Location:
13q34
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (113323252..113364158, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (113978505..114018463, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene cullin 4A Neighboring gene microRNA 8075 Neighboring gene lactate dehydrogenase B pseudogene 1 Neighboring gene lysosomal associated membrane protein 1 Neighboring gene GRTP1 antisense RNA 1 Neighboring gene collagen alpha-1(II) chain-like Neighboring gene ADP-ribosylhydrolase like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of growth hormone regulated TBC protein 1 (GRTP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22474, MGC138328, MGC138330

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
growth hormone-regulated TBC protein 1
Names
TBC1 domain family member 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286732.1NP_001273661.1  growth hormone-regulated TBC protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001273661.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a 3' coding exon and its 3' terminal exon extends past a splice site that is used in variant 1, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AB449887, AK026127, CX788865
    Consensus CDS
    CCDS66591.1
    UniProtKB/Swiss-Prot
    Q5TC63
    Related
    ENSP00000364579.4, ENST00000375430.8
    Conserved Domains (1) summary
    smart00164
    Location:65278
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  2. NM_001286733.1NP_001273662.1  growth hormone-regulated TBC protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL136221, AW243250, BC062461, BQ689859, CX788865
    Consensus CDS
    CCDS73606.1
    UniProtKB/Swiss-Prot
    Q5TC63
    UniProtKB/TrEMBL
    A0A087X0Y1
    Related
    ENSP00000483734.1, ENST00000620217.4
    Conserved Domains (1) summary
    smart00164
    Location:65187
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  3. NM_024719.4NP_078995.2  growth hormone-regulated TBC protein 1 isoform 1

    See identical proteins and their annotated locations for NP_078995.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL136221, AW243250, BC062461, CX788865
    Consensus CDS
    CCDS9534.2
    UniProtKB/Swiss-Prot
    Q5TC63
    Related
    ENSP00000364580.3, ENST00000375431.9
    Conserved Domains (1) summary
    smart00164
    Location:65278
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    113323252..113364158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020755.2XP_016876244.1  growth hormone-regulated TBC protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q5TC63
    Related
    ENSP00000321850.3, ENST00000326039.3
  2. XM_005268333.4XP_005268390.1  growth hormone-regulated TBC protein 1 isoform X1

    Conserved Domains (1) summary
    pfam00566
    Location:59225
    RabGAP-TBC; Rab-GTPase-TBC domain
  3. XM_017020756.2XP_016876245.1  growth hormone-regulated TBC protein 1 isoform X3

    Conserved Domains (1) summary
    pfam00566
    Location:9175
    RabGAP-TBC; Rab-GTPase-TBC domain
  4. XM_011537521.3XP_011535823.1  growth hormone-regulated TBC protein 1 isoform X4

    Conserved Domains (1) summary
    smart00164
    Location:65187
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  5. XM_011537522.2XP_011535824.1  growth hormone-regulated TBC protein 1 isoform X5

    Conserved Domains (1) summary
    smart00164
    Location:65187
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RNA

  1. XR_944280.2 RNA Sequence

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