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ELMO3 engulfment and cell motility 3 [ Homo sapiens (human) ]

Gene ID: 79767, updated on 1-Jun-2020

Summary

Official Symbol
ELMO3provided by HGNC
Official Full Name
engulfment and cell motility 3provided by HGNC
Primary source
HGNC:HGNC:17289
See related
Ensembl:ENSG00000102890 MIM:606422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CED12; CED-12; ELMO-3
Summary
The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]
Expression
Broad expression in duodenum (RPKM 15.2), skin (RPKM 12.9) and 20 other tissues See more
Orthologs

Genomic context

See ELMO3 in Genome Data Viewer
Location:
16q22.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67199131..67204029)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67233014..67237932)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene exocyst complex component 3 like 1 Neighboring gene E2F transcription factor 4 Neighboring gene microRNA 328 Neighboring gene leucine rich repeat containing 29 Neighboring gene transmembrane protein 208

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13824

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rac GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
engulfment and cell motility protein 3
Names
ced-12 homolog 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024712.5NP_078988.3  engulfment and cell motility protein 3

    Status: REVIEWED

    Source sequence(s)
    AC040160, BC034410, DA872517
    Consensus CDS
    CCDS10833.2
    Related
    ENSP00000377566.3, ENST00000393997.8
    Conserved Domains (3) summary
    cd13359
    Location:534663
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:292463
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116267
    DUF3361; Domain of unknown function (DUF3361)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67199131..67204029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450447.1XP_024306215.1  engulfment and cell motility protein 3 isoform X1

    Conserved Domains (3) summary
    pfam04727
    Location:115286
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:390
    DUF3361; Domain of unknown function (DUF3361)
    cl17171
    Location:357486
    PH-like; Pleckstrin homology-like domain
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