Format

Send to:

Choose Destination

ZFAND1 zinc finger AN1-type containing 1 [ Homo sapiens (human) ]

Gene ID: 79752, updated on 4-Oct-2020

Summary

Official Symbol
ZFAND1provided by HGNC
Official Full Name
zinc finger AN1-type containing 1provided by HGNC
Primary source
HGNC:HGNC:25858
See related
Ensembl:ENSG00000104231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 23.7), ovary (RPKM 15.6) and 25 other tissues See more
Orthologs

Genomic context

See ZFAND1 in Genome Data Viewer
Location:
8q21.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (81701331..81721304, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (82613566..82633539, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene inositol monophosphatase 1 Neighboring gene solute carrier family 10 member 5 Neighboring gene charged multivesicular body protein 4C Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 36 Neighboring gene sorting nexin 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14007

Gene Ontology Provided by GOA

Function Evidence Code Pubs
proteasome binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to arsenite ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT cellular response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT cellular response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
stress granule disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
AN1-type zinc finger protein 1
Names
zinc finger AN1-type-containing protein 1
zinc finger, AN1-type domain 1
NP_001164267.1
NP_001164268.1
NP_078975.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170796.1NP_001164267.1  AN1-type zinc finger protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC132219, AK225195, BQ427843, BU678501
    Consensus CDS
    CCDS55251.1
    UniProtKB/Swiss-Prot
    Q8TCF1
    Related
    ENSP00000430736.1, ENST00000523096.5
    Conserved Domains (1) summary
    pfam01428
    Location:1046
    zf-AN1; AN1-like Zinc finger
  2. NM_001170797.2NP_001164268.1  AN1-type zinc finger protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1, resulting in an isoform (c) with a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    BQ427843, CA412820
    Consensus CDS
    CCDS55250.1
    UniProtKB/Swiss-Prot
    Q8TCF1
    Related
    ENSP00000429167.1, ENST00000519523.5
    Conserved Domains (1) summary
    pfam01428
    Location:1046
    zf-AN1; AN1-like Zinc finger
  3. NM_024699.3NP_078975.2  AN1-type zinc finger protein 1 isoform a

    See identical proteins and their annotated locations for NP_078975.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC132219, BC022251, BQ427843, BU678501
    Consensus CDS
    CCDS6232.1
    UniProtKB/Swiss-Prot
    Q8TCF1
    Related
    ENSP00000220669.5, ENST00000220669.10
    Conserved Domains (1) summary
    pfam01428
    Location:1046
    zf-AN1; AN1-like Zinc finger

RNA

  1. NR_033193.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon but includes a different alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of upstream ORFs that are predicted to interfere with the translation of the longest ORF; translation from an upstream ORF makes the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132219, BG618233, BQ427843, BU678501
  2. NR_033194.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of upstream ORFs that are predicted to interfere with the translation of the longest ORF; translation from an upstream ORF makes the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132219, BC051857, BQ427843, BU678501
  3. NR_033195.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the 5' exon and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of upstream ORFs that are predicted to interfere with the translation of the longest ORF; translation from an upstream ORF makes the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132219, BQ427843, BQ435400, BU678501
  4. NR_033196.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate internal exon and differs in its 3'-most exon, compared to variant 1. This variant is represented as non-coding due to the presence of upstream ORFs that are predicted to interfere with the translation of the longest ORF; translation from an upstream ORF makes the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132219, BQ427843, BU624414
    Related
    ENST00000517588.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    81701331..81721304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center