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ZNF385D zinc finger protein 385D [ Homo sapiens (human) ]

Gene ID: 79750, updated on 5-Jan-2022

Summary

Official Symbol
ZNF385Dprovided by HGNC
Official Full Name
zinc finger protein 385Dprovided by HGNC
Primary source
HGNC:HGNC:26191
See related
Ensembl:ENSG00000151789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF659
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in testis (RPKM 1.9), brain (RPKM 1.5) and 16 other tissues See more
Orthologs
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Genomic context

See ZNF385D in Genome Data Viewer
Location:
3p24.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (21412218..22372641, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (21453710..21792702, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376988 Neighboring gene VENT homeobox pseudogene 7 Neighboring gene ZNF385D antisense RNA 1 Neighboring gene ZNF385D antisense RNA 2 Neighboring gene high mobility group box 1 pseudogene 5 Neighboring gene RRBP1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
EBI GWAS Catalog
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
EBI GWAS Catalog
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
EBI GWAS Catalog
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog
Host determinants of HIV-1 control in African Americans.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22419

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 385D
Names
zinc finger protein 659

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024697.3NP_078973.1  zinc finger protein 385D

    See identical proteins and their annotated locations for NP_078973.1

    Status: VALIDATED

    Source sequence(s)
    AC104183, AK026072
    Consensus CDS
    CCDS2636.1
    UniProtKB/Swiss-Prot
    Q9H6B1
    Related
    ENSP00000281523.2, ENST00000281523.8
    Conserved Domains (2) summary
    sd00020
    Location:206228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:267291
    zf-met; Zinc-finger of C2H2 type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    21412218..22372641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007192.1XP_016862681.1  zinc finger protein 385D isoform X2

    Conserved Domains (2) summary
    sd00020
    Location:307329
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:368392
    zf-met; Zinc-finger of C2H2 type
  2. XM_017007191.1XP_016862680.1  zinc finger protein 385D isoform X1

    Conserved Domains (2) summary
    sd00020
    Location:326348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:388411
    zf-met; Zinc-finger of C2H2 type
  3. XM_017007194.1XP_016862683.1  zinc finger protein 385D isoform X4

    Conserved Domains (2) summary
    sd00020
    Location:242264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:304327
    zf-met; Zinc-finger of C2H2 type
  4. XM_017007199.1XP_016862688.1  zinc finger protein 385D isoform X9

    Conserved Domains (2) summary
    sd00020
    Location:173195
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:235258
    zf-met; Zinc-finger of C2H2 type
  5. XM_017007198.1XP_016862687.1  zinc finger protein 385D isoform X8

  6. XM_017007195.1XP_016862684.1  zinc finger protein 385D isoform X5

    Conserved Domains (2) summary
    sd00020
    Location:240262
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:302325
    zf-met; Zinc-finger of C2H2 type
  7. XM_017007193.1XP_016862682.1  zinc finger protein 385D isoform X3

    Conserved Domains (2) summary
    sd00020
    Location:255277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:317340
    zf-met; Zinc-finger of C2H2 type
  8. XM_017007196.1XP_016862685.1  zinc finger protein 385D isoform X6

    Conserved Domains (2) summary
    sd00020
    Location:225247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:287310
    zf-met; Zinc-finger of C2H2 type
  9. XM_017007197.1XP_016862686.1  zinc finger protein 385D isoform X7

  10. XM_017007200.2XP_016862689.1  zinc finger protein 385D isoform X10

    Conserved Domains (2) summary
    sd00020
    Location:170192
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:232255
    zf-met; Zinc-finger of C2H2 type
  11. XM_017007201.1XP_016862690.1  zinc finger protein 385D isoform X11

    Conserved Domains (2) summary
    sd00020
    Location:112134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:174197
    zf-met; Zinc-finger of C2H2 type
  12. XM_017007202.1XP_016862691.1  zinc finger protein 385D isoform X13

    Conserved Domains (2) summary
    sd00020
    Location:7395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:135158
    zf-met; Zinc-finger of C2H2 type
  13. XM_011534122.2XP_011532424.1  zinc finger protein 385D isoform X12

    See identical proteins and their annotated locations for XP_011532424.1

    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:7092
    zf-met; Zinc-finger of C2H2 type
  14. XM_024453754.1XP_024309522.1  zinc finger protein 385D isoform X15

    Conserved Domains (2) summary
    sd00020
    Location:97119
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:97119
    zf-met; Zinc-finger of C2H2 type
  15. XM_011534124.3XP_011532426.1  zinc finger protein 385D isoform X12

    See identical proteins and their annotated locations for XP_011532426.1

    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:7092
    zf-met; Zinc-finger of C2H2 type
  16. XM_017007203.1XP_016862692.1  zinc finger protein 385D isoform X14

    Related
    ENSP00000495609.2, ENST00000494108.2
  17. XM_011534123.2XP_011532425.1  zinc finger protein 385D isoform X12

    See identical proteins and their annotated locations for XP_011532425.1

    Conserved Domains (2) summary
    sd00020
    Location:183205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:7092
    zf-met; Zinc-finger of C2H2 type
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