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LMAN1L lectin, mannose binding 1 like [ Homo sapiens (human) ]

Gene ID: 79748, updated on 2-Nov-2024

Summary

Official Symbol
LMAN1Lprovided by HGNC
Official Full Name
lectin, mannose binding 1 likeprovided by HGNC
Primary source
HGNC:HGNC:6632
See related
Ensembl:ENSG00000140506 MIM:609548; AllianceGenome:HGNC:6632
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERGL; ERGIC-53L
Summary
This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This lectin is thought to transport newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. [provided by RefSeq, Jan 2017]
Expression
Biased expression in prostate (RPKM 62.2), spleen (RPKM 25.8) and 2 other tissues See more
Orthologs
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Genomic context

See LMAN1L in Genome Data Viewer
Location:
15q24.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (74812835..74825754)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (72682728..72695650)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75105176..75118095)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CYP1A2 5' regulatory region Neighboring gene cytochrome P450 family 1 subfamily A member 2 Neighboring gene dioxin-responsive -38 kb CYP1A2 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75059675-75060452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75063617-75064332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75064333-75065046 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75066003-75066580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75070096-75070626 Neighboring gene Sharpr-MPRA regulatory region 4992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6657 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75075123-75075698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9793 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9796 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:75080141-75080318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75084649-75085478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75085479-75086307 Neighboring gene C-terminal Src kinase Neighboring gene microRNA 4513 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:75090696-75091895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75092171-75093022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75093023-75093872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75112197-75113010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75113011-75113824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75114639-75115451 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:75118950-75119157 Neighboring gene uncharacterized LOC105370897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9808 Neighboring gene complexin 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:75128807-75129383 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:75131867-75132014 Neighboring gene unc-51 like kinase 3 Neighboring gene microRNA 6882

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure.
EBI GWAS Catalog
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
protein ERGIC-53-like
Names
ERGIC53-like protein
LMAN1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052659.1 RefSeqGene

    Range
    4983..17902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021819.3NP_068591.2  protein ERGIC-53-like precursor

    See identical proteins and their annotated locations for NP_068591.2

    Status: REVIEWED

    Source sequence(s)
    AC091230, AF303398, AY358724
    Consensus CDS
    CCDS10270.1
    UniProtKB/Swiss-Prot
    Q6UWN2, Q9HAT1
    UniProtKB/TrEMBL
    A8K704
    Related
    ENSP00000310431.5, ENST00000309664.10
    Conserved Domains (1) summary
    cl14058
    Location:31253
    lectin_L-type; legume lectins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    74812835..74825754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    72682728..72695650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)