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LMAN1L lectin, mannose binding 1 like [ Homo sapiens (human) ]

Gene ID: 79748, updated on 21-Dec-2019

Summary

Official Symbol
LMAN1Lprovided by HGNC
Official Full Name
lectin, mannose binding 1 likeprovided by HGNC
Primary source
HGNC:HGNC:6632
See related
Ensembl:ENSG00000140506 MIM:609548
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERGL; ERGIC-53L
Summary
This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This lectin is thought to transport newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. [provided by RefSeq, Jan 2017]
Expression
Biased expression in prostate (RPKM 62.2), spleen (RPKM 25.8) and 2 other tissues See more
Orthologs

Genomic context

See LMAN1L in Genome Data Viewer
Location:
15q24.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74812835..74825754)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75105194..75118099)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene enhancer downstream of CYP1A2 Neighboring gene C-terminal Src kinase Neighboring gene microRNA 4513 Neighboring gene uncharacterized LOC105370897 Neighboring gene complexin 3 Neighboring gene unc-51 like kinase 3 Neighboring gene microRNA 6882

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CPLX3

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein ERGIC-53-like
Names
ERGIC53-like protein
LMAN1-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052659.1 RefSeqGene

    Range
    4983..17902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021819.3NP_068591.2  protein ERGIC-53-like precursor

    See identical proteins and their annotated locations for NP_068591.2

    Status: REVIEWED

    Source sequence(s)
    AC091230, AF303398, AY358724
    Consensus CDS
    CCDS10270.1
    UniProtKB/Swiss-Prot
    Q9HAT1
    Related
    ENSP00000310431.5, ENST00000309664.10
    Conserved Domains (1) summary
    cl14058
    Location:31253
    lectin_L-type; legume lectins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74812835..74825754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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