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ADGB androglobin [ Homo sapiens (human) ]

Gene ID: 79747, updated on 6-Sep-2021

Summary

Official Symbol
ADGBprovided by HGNC
Official Full Name
androglobinprovided by HGNC
Primary source
HGNC:HGNC:21212
See related
Ensembl:ENSG00000118492 MIM:614630
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPN16; C6orf103
Expression
Biased expression in testis (RPKM 2.9) and lung (RPKM 0.4) See more
Orthologs
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Genomic context

See ADGB in Genome Data Viewer
Location:
6q24.3
Exon count:
36
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (146598972..146815462)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (146920108..147136598)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4102 Neighboring gene RAB32, member RAS oncogene family Neighboring gene ADGB divergent transcript Neighboring gene uncharacterized LOC105378041 Neighboring gene uncharacterized LOC105378040 Neighboring gene katanin regulatory subunit B1 like 1 pseudogene 6 Neighboring gene STXBP5 antisense RNA 1 Neighboring gene lung adenocarcinoma associated transcript 1 Neighboring gene syntaxin binding protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
androglobin
Names
calpain-7-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024694.4NP_078970.3  androglobin

    See identical proteins and their annotated locations for NP_078970.3

    Status: VALIDATED

    Source sequence(s)
    AK026774, AK097570, AL359547, AL832192, BG199812, DN831198
    UniProtKB/Swiss-Prot
    Q8N7X0
    UniProtKB/TrEMBL
    Q9H5S1
    Related
    ENSP00000381036.3, ENST00000397944.8
    Conserved Domains (2) summary
    cd01040
    Location:780853
    Mb_like; myoglobin_like; M family globin domain
    cl00051
    Location:192299
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    146598972..146815462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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