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CLIP4 CAP-Gly domain containing linker protein family member 4 [ Homo sapiens (human) ]

Gene ID: 79745, updated on 12-Oct-2019

Summary

Official Symbol
CLIP4provided by HGNC
Official Full Name
CAP-Gly domain containing linker protein family member 4provided by HGNC
Primary source
HGNC:HGNC:26108
See related
Ensembl:ENSG00000115295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSNL2
Expression
Ubiquitous expression in thyroid (RPKM 10.8), skin (RPKM 7.6) and 23 other tissues See more
Orthologs

Genomic context

See CLIP4 in Genome Data Viewer
Location:
2p23.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (29097676..29183808)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (29320542..29406679)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374386 Neighboring gene CLIP4 5' region CAGE-defined mid-level expression enhancer Neighboring gene photoreceptor cilium actin regulator Neighboring gene ALK receptor tyrosine kinase Neighboring gene uncharacterized LOC101929386 Neighboring gene uncharacterized LOC105374389

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21069, FLJ32705

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
CAP-Gly domain-containing linker protein 4
Names
CAP-GLY domain containing linker protein family, member 4
restin-like protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287527.2NP_001274456.1  CAP-Gly domain-containing linker protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001274456.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC105398, AK023505, AK304384, AL834443, BI600762
    Consensus CDS
    CCDS1770.1
    UniProtKB/Swiss-Prot
    Q8N3C7
    UniProtKB/TrEMBL
    B7Z936
    Conserved Domains (3) summary
    cd00204
    Location:98252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:487551
    CAP_GLY; CAP-Gly domain
  2. NM_001287528.1NP_001274457.1  CAP-Gly domain-containing linker protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001274457.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA429893, AF433661, AK291595, AK302325, DC317668
    Consensus CDS
    CCDS74502.1
    UniProtKB/Swiss-Prot
    Q8N3C7
    UniProtKB/TrEMBL
    A8K6D0
    Related
    ENSP00000384242.1, ENST00000401605.5
    Conserved Domains (4) summary
    cd00204
    Location:98252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01302
    Location:488551
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
  3. NM_024692.6NP_078968.3  CAP-Gly domain-containing linker protein 4 isoform 1

    See identical proteins and their annotated locations for NP_078968.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC105398, AK023505, AK304384, AL834443, BI600762
    Consensus CDS
    CCDS1770.1
    UniProtKB/Swiss-Prot
    Q8N3C7
    UniProtKB/TrEMBL
    B7Z936
    Related
    ENSP00000327009.5, ENST00000320081.10
    Conserved Domains (3) summary
    cd00204
    Location:98252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:487551
    CAP_GLY; CAP-Gly domain

RNA

  1. NR_109844.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses alternate 5' and 3'-terminal exons, lacks an internal exon, and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA429893, AK057267, AL834443
    Related
    ENST00000456385.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    29097676..29183808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264562.2XP_005264619.1  CAP-Gly domain-containing linker protein 4 isoform X1

    See identical proteins and their annotated locations for XP_005264619.1

    UniProtKB/Swiss-Prot
    Q8N3C7
    Conserved Domains (3) summary
    cd00204
    Location:98252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:487551
    CAP_GLY; CAP-Gly domain
  2. XM_011533110.1XP_011531412.1  CAP-Gly domain-containing linker protein 4 isoform X3

    Related
    ENSP00000385148.2, ENST00000401617.6
    Conserved Domains (4) summary
    cd00204
    Location:1145
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01302
    Location:381444
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:4110
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:4677
    ANK; ANK repeat [structural motif]
  3. XM_006712104.2XP_006712167.1  CAP-Gly domain-containing linker protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006712167.1

    UniProtKB/Swiss-Prot
    Q8N3C7
    Related
    ENSP00000385594.1, ENST00000404424.5
    Conserved Domains (3) summary
    cd00204
    Location:98252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:487551
    CAP_GLY; CAP-Gly domain
  4. XM_005264563.1XP_005264620.1  CAP-Gly domain-containing linker protein 4 isoform X1

    See identical proteins and their annotated locations for XP_005264620.1

    UniProtKB/Swiss-Prot
    Q8N3C7
    Conserved Domains (3) summary
    cd00204
    Location:98252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:487551
    CAP_GLY; CAP-Gly domain
  5. XM_011533109.1XP_011531411.1  CAP-Gly domain-containing linker protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011531411.1

    UniProtKB/Swiss-Prot
    Q8N3C7
    Conserved Domains (3) summary
    cd00204
    Location:98252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:487551
    CAP_GLY; CAP-Gly domain
  6. XM_017004958.1XP_016860447.1  CAP-Gly domain-containing linker protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8N3C7
    Conserved Domains (3) summary
    cd00204
    Location:98252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:487551
    CAP_GLY; CAP-Gly domain
  7. XM_006712105.4XP_006712168.1  CAP-Gly domain-containing linker protein 4 isoform X4

    Conserved Domains (4) summary
    cd00204
    Location:98252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01302
    Location:488551
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
  8. XM_017004959.2XP_016860448.1  CAP-Gly domain-containing linker protein 4 isoform X2

RNA

  1. XR_001738944.2 RNA Sequence

  2. XR_939718.3 RNA Sequence

  3. XR_002959339.1 RNA Sequence

  4. XR_939717.3 RNA Sequence

  5. XR_939719.3 RNA Sequence

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