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ZNF419 zinc finger protein 419 [ Homo sapiens (human) ]

Gene ID: 79744, updated on 23-Nov-2021

Summary

Official Symbol
ZNF419provided by HGNC
Official Full Name
zinc finger protein 419provided by HGNC
Primary source
HGNC:HGNC:20648
See related
Ensembl:ENSG00000105136 MIM:617410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAPHIR; ZNF419A
Expression
Ubiquitous expression in thyroid (RPKM 5.2), spleen (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF419 in Genome Data Viewer
Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57487720..57496098)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57999118..58007466)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 107 pseudogene Neighboring gene zinc finger protein 772 Neighboring gene zinc finger protein 773 Neighboring gene zinc finger protein 549

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 419
Names
zinc finger protein 419A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054882.1 RefSeqGene

    Range
    5040..13388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098491.2NP_001091961.1  zinc finger protein 419 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC003005, AK026886, BC024259, DB004191
    Consensus CDS
    CCDS54325.1
    UniProtKB/Swiss-Prot
    Q96HQ0
    Related
    ENSP00000388864.1, ENST00000424930.6
    Conserved Domains (5) summary
    smart00349
    Location:2888
    KRAB; krueppel associated box
    COG5048
    Location:262418
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262282
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2867
    KRAB; KRAB box
    pfam13465
    Location:330355
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001098492.2NP_001091962.1  zinc finger protein 419 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AC003005, AK026886, BC024259, DC315347
    Consensus CDS
    CCDS54327.1
    UniProtKB/Swiss-Prot
    Q96HQ0
    Related
    ENSP00000390916.1, ENST00000426954.6
    Conserved Domains (5) summary
    smart00349
    Location:1575
    KRAB; krueppel associated box
    COG5048
    Location:249405
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:249269
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1554
    KRAB; KRAB box
    pfam13465
    Location:317342
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001098493.2NP_001091963.1  zinc finger protein 419 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.
    Source sequence(s)
    AC003005, AK026886, BC024259, DC392630
    Consensus CDS
    CCDS54328.1
    UniProtKB/Swiss-Prot
    Q96HQ0
    Related
    ENSP00000414709.2, ENST00000442920.6
    Conserved Domains (5) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:248404
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:248268
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:316341
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001098494.2NP_001091964.1  zinc finger protein 419 isoform 5

    See identical proteins and their annotated locations for NP_001091964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (5) that is shorter than isoform 1.
    Source sequence(s)
    AC003005, AK026886, BC024259
    Consensus CDS
    CCDS42637.1
    UniProtKB/Swiss-Prot
    Q96HQ0
    Related
    ENSP00000299860.9, ENST00000347466.10
    Conserved Domains (5) summary
    smart00349
    Location:2869
    KRAB; krueppel associated box
    COG5048
    Location:229385
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:229249
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2867
    KRAB; KRAB box
    pfam13465
    Location:297322
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001098495.2NP_001091965.1  zinc finger protein 419 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1, resulting in an isoform (6) that is shorter than isoform 1.
    Source sequence(s)
    AC003005, AK026886, BC024259, BP336834, DC407547
    UniProtKB/Swiss-Prot
    Q96HQ0
    Conserved Domains (5) summary
    smart00349
    Location:1556
    KRAB; krueppel associated box
    COG5048
    Location:216372
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216236
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1554
    KRAB; KRAB box
    pfam13465
    Location:284309
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001098496.2NP_001091966.1  zinc finger protein 419 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two alternate in-frame exons and and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (7) that is shorter than isoform 1.
    Source sequence(s)
    AC003005, AK026886, BC024259, DC315347, DC425209
    Consensus CDS
    CCDS46211.1
    UniProtKB/Swiss-Prot
    Q96HQ0
    Related
    ENSP00000392129.2, ENST00000415379.6
    Conserved Domains (5) summary
    smart00349
    Location:1455
    KRAB; krueppel associated box
    COG5048
    Location:215371
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:215235
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:283308
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001291743.2NP_001278672.1  zinc finger protein 419 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (8) that is shorter than isoform 1.
    Source sequence(s)
    AC003005, AK026886, BC008297, CT002615, DC315347
    UniProtKB/Swiss-Prot
    Q96HQ0
    Conserved Domains (5) summary
    smart00349
    Location:2768
    KRAB; krueppel associated box
    COG5048
    Location:228384
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:228248
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:296321
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001291744.2NP_001278673.1  zinc finger protein 419 isoform 9 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice site and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, and it also lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (9) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC003005, AK026886, BC008297, DA548110, DC315347
    UniProtKB/Swiss-Prot
    Q96HQ0
    Conserved Domains (3) summary
    COG5048
    Location:173329
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:241266
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001291745.2NP_001278674.1  zinc finger protein 419 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks an alternate in-frame exon in the 5' coding region, and it uses an alternate splice site in its 3' terminal exon and thus differs in the 3' coding region, compared to variant 1. The encoded isoform (10) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC008297, BF110540, DC315347
    UniProtKB/Swiss-Prot
    Q96HQ0
    Conserved Domains (2) summary
    smart00349
    Location:1575
    KRAB; krueppel associated box
    pfam01352
    Location:1554
    KRAB; KRAB box
  10. NM_024691.4NP_078967.3  zinc finger protein 419 isoform 2

    See identical proteins and their annotated locations for NP_078967.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC003005, AK026886, BC024259, BP336834
    Consensus CDS
    CCDS54326.1
    UniProtKB/Swiss-Prot
    Q96HQ0
    Related
    ENSP00000221735.7, ENST00000221735.12
    Conserved Domains (5) summary
    smart00349
    Location:2787
    KRAB; krueppel associated box
    COG5048
    Location:261417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:261281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:329354
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57487720..57496098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451720.1XP_024307488.1  zinc finger protein 419 isoform X1

    Conserved Domains (1) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
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