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espl1 extra spindle pole bodies like 1, separase [ Danio rerio (zebrafish) ]

Gene ID: 797406, updated on 9-Sep-2025
Official Symbol
espl1provided by ZNC
Official Full Name
extra spindle pole bodies like 1, separaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5188
See related
Ensembl:ENSDARG00000075354 AllianceGenome:ZFIN:ZDB-GENE-030131-5188
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
espl1,; fl55e11; wu:fl55e11; mp:zf637-3-001691
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in meiotic chromosome separation. Predicted to act upstream of or within chromosome segregation and proteolysis. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Orthologous to human ESPL1 (extra spindle pole bodies like 1, separase). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
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See espl1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (42220294..42252320, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (39668848..39700893, complement)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene La ribonucleoprotein 4Ab Neighboring gene prefoldin 5 Neighboring gene integrin, beta 7 Neighboring gene phosphofructokinase, muscle b Neighboring gene uncharacterized LOC141386327

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic chromosome separation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
separin
Names
cease and desist
extra spindle pole bodies homolog 1
extra spindle poles like 1
separase
XP_021329798.2
XP_021329799.2

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    42220294..42252320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474124.3XP_021329799.2  separin isoform X2

    UniProtKB/TrEMBL
    A0A8M2BDI2, A0A8M9PY30
  2. XM_021474123.3XP_021329798.2  separin isoform X1

    UniProtKB/TrEMBL
    A0A8M1Q1L6, A0A8M9PRZ2, E7FDD8