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E2F8 E2F transcription factor 8 [ Homo sapiens (human) ]

Gene ID: 79733, updated on 10-Oct-2019

Summary

Official Symbol
E2F8provided by HGNC
Official Full Name
E2F transcription factor 8provided by HGNC
Primary source
HGNC:HGNC:24727
See related
Ensembl:ENSG00000129173 MIM:612047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E2F-8
Summary
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Expression
Broad expression in bone marrow (RPKM 4.6), lymph node (RPKM 3.5) and 14 other tissues See more
Orthologs

Genomic context

See E2F8 in Genome Data Viewer
Location:
11p15.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (19224063..19241655, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (19245610..19263202, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs2145 Neighboring gene CSRP3 and E2F8 antisense RNA 1 Neighboring gene cysteine and glycine rich protein 3 Neighboring gene proliferating cell nuclear antigen pseudogene 4 Neighboring gene RNA, 5S ribosomal pseudogene 335 Neighboring gene neuron navigator 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23311

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
cell cycle comprising mitosis without cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
chorionic trophoblast cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
hepatocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
placenta development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA endoreduplication ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
trophoblast giant cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor E2F8
Names
E2F family member 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256371.1NP_001243300.1  transcription factor E2F8

    See identical proteins and their annotated locations for NP_001243300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC009652, BM972658, DA758300
    Consensus CDS
    CCDS7849.1
    UniProtKB/Swiss-Prot
    A0AVK6
    Related
    ENSP00000481103.1, ENST00000620009.4
    Conserved Domains (2) summary
    pfam02319
    Location:114182
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    cl26464
    Location:464700
    Atrophin-1; Atrophin-1 family
  2. NM_001256372.1NP_001243301.1  transcription factor E2F8

    See identical proteins and their annotated locations for NP_001243301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC009652, AK292688, BM972658, BX504614
    Consensus CDS
    CCDS7849.1
    UniProtKB/Swiss-Prot
    A0AVK6
    Related
    ENSP00000434199.1, ENST00000527884.5
    Conserved Domains (2) summary
    pfam02319
    Location:114182
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    cl26464
    Location:464700
    Atrophin-1; Atrophin-1 family
  3. NM_024680.4NP_078956.2  transcription factor E2F8

    See identical proteins and their annotated locations for NP_078956.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK026964, AK055206, BC028244, BM972658, BU164108, BX504614, CB959621
    Consensus CDS
    CCDS7849.1
    UniProtKB/Swiss-Prot
    A0AVK6
    Related
    ENSP00000250024.4, ENST00000250024.9
    Conserved Domains (2) summary
    pfam02319
    Location:114182
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    cl26464
    Location:464700
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    19224063..19241655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520367.1XP_011518669.1  transcription factor E2F8 isoform X1

    Conserved Domains (1) summary
    pfam02319
    Location:158242
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RNA

  1. XR_930907.2 RNA Sequence

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