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sox18 SRY-box transcription factor 18 [ Danio rerio (zebrafish) ]

Gene ID: 797246, updated on 6-Jul-2026
Official Symbol
sox18provided by ZNC
Official Full Name
SRY-box transcription factor 18provided by ZNC
Primary source
ZFIN:ZDB-GENE-080725-1
See related
Ensembl:ENSDARG00000058598 AllianceGenome:ZFIN:ZDB-GENE-080725-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-235f6.2
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within artery development; lymphangiogenesis; and vasculogenesis. Predicted to be active in nucleus. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; immature eye; intermediate cell mass of mesoderm; and mesoderm. Human ortholog(s) of this gene implicated in hypotrichosis-lymphedema-telangiectasia syndrome and hypotrichosis-lymphedema-telangiectasia-renal defect syndrome. Orthologous to human SOX18 (SRY-box transcription factor 18). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See sox18 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 23 NC_133198.1 (8927877..8931505)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 23 NC_007134.7 (8797126..8800490)

Chromosome 23 - NC_133198.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489087 Neighboring gene regulator of G protein signaling 19 Neighboring gene uncharacterized LOC141380640 Neighboring gene transcription elongation factor A (SII), 2 Neighboring gene uncharacterized LOC141380641 Neighboring gene XK, Kell blood group complex subunit-related family, member 7b Neighboring gene CCM2 like scaffold protein

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Homodimerization regulates an endothelial specific signature of the SOX18 transcription factor. Moustaqil M, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30335167, Free PMC Article
  2. Methylome analysis for spina bifida shows SOX18 hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development. Rochtus A, et al. Clin Epigenetics, 2016. PMID 27757173, Free PMC Article
  3. Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafish. Samant GV, et al. J Biol Chem, 2011 Sep 2. PMID 21730073, Free PMC Article
  4. Divergence of zebrafish and mouse lymphatic cell fate specification pathways. van Impel A, et al. Development, 2014 Mar. PMID 24523456, Free PMC Article
  5. Lymphatic Defects in Zebrafish sox18 Mutants Are Exacerbated by Perturbed VEGFC Signaling, While Masked by Elevated sox7 Expression. Moleri S, et al. Cells, 2023 Sep 19. PMID 37759531, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lymphatic Defects in Zebrafish sox18 Mutants Are Exacerbated by Perturbed VEGFC Signaling, While Masked by Elevated sox7 Expression.
    Title: Lymphatic Defects in Zebrafish sox18 Mutants Are Exacerbated by Perturbed VEGFC Signaling, While Masked by Elevated sox7 Expression.
  2. Sox7/18 factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish.
    Title: SoxF factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish.
  3. VEGFD-mediated pathologies include or involve an underlying dysregulation of SOXF-mediated transcriptional networks.
    Title: VEGFD regulates blood vascular development by modulating SOX18 activity.
  4. Sox7 and Sox18-mediated transcriptional regulation of Robo4 is important in the developing embryonic vasculature
    Title: Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafish.
  5. Sox7 and sox18 play redundant but collectively essential roles in the establishment of proper arteriovenous identity in zebrafish.
    Title: Sox18 and Sox7 play redundant roles in vascular development.
  6. Sox7 and sox18 are specifically expressed in the developing vasculature, and simultaneous loss of their function results in a severe loss of the arterial identity of the presumptive aorta.
    Title: Redundant roles for sox7 and sox18 in arteriovenous specification in zebrafish.
  7. Sox7 and Sox18 control arterial-venous identity by regulating Gridlock expression.
    Title: Zebrafish Sox7 and Sox18 function together to control arterial-venous identity.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within artery development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within blood vessel development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lymphangiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lymphangiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vasculogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vasculogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
transcription factor Sox-18
Names
SRY (sex determining region Y)-box 18
SRY-box containing gene 18

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133198.1 Reference GRCz12tu Primary Assembly

    Range
    8927877..8931505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017353772.4 → XP_017209261.1  transcription factor Sox-18

    UniProtKB/TrEMBL
    A0A8M6YY05, E7F9I2, E9QI55
    Related
    ENSDARP00000113837.2
    Conserved Domains (2) summary
    cd01388
    Location:93 → 164
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam12067
    Location:207 → 429
    Sox_C_TAD; Sox C-terminal transactivation domain
Nucleotide Protein Strain
Heading Accession and Version

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