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SUV39H2 SUV39H2 histone lysine methyltransferase [ Homo sapiens (human) ]

Gene ID: 79723, updated on 6-Sep-2021

Summary

Official Symbol
SUV39H2provided by HGNC
Official Full Name
SUV39H2 histone lysine methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:17287
See related
Ensembl:ENSG00000152455 MIM:606503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KMT1B
Expression
Broad expression in testis (RPKM 10.3), lymph node (RPKM 2.1) and 23 other tissues See more
Orthologs
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Genomic context

See SUV39H2 in Genome Data Viewer
Location:
10p13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (14878866..14904315)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (14920865..14946314)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 29 Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene heat shock protein family A (Hsp70) member 14 Neighboring gene DNA cross-link repair 1C Neighboring gene meiosis/spermiogenesis associated 1 Neighboring gene olfactory receptor family 7 subfamily E member 110 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 26 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23414

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone methyltransferase activity (H3-K9 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone methyltransferase activity (H3-K9 specific) IDA
Inferred from Direct Assay
more info
PubMed 
enables histone-lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin assembly or disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H3-K9 dimethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in histone H3-K9 trimethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in histone lysine methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
histone-lysine N-methyltransferase SUV39H2
Names
H3-K9-HMTase 2
histone H3-K9 methyltransferase 2
histone methyltransferase SUV39H2
lysine N-methyltransferase 1B
su(var)3-9 homolog 2
suppressor of variegation 3-9 homolog 2
NP_001180353.1
NP_001180354.1
NP_001180355.1
NP_001180356.1
NP_078946.1
XP_006717566.1
XP_011517964.1
XP_016872126.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193424.2NP_001180353.1  histone-lysine N-methyltransferase SUV39H2 isoform 1

    See identical proteins and their annotated locations for NP_001180353.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1).
    Source sequence(s)
    BC007754, DB040298
    Consensus CDS
    CCDS53494.1
    UniProtKB/Swiss-Prot
    Q9H5I1
    Related
    ENSP00000346997.6, ENST00000354919.11
    Conserved Domains (2) summary
    cd18639
    Location:4795
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cd10532
    Location:167409
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
  2. NM_001193425.2NP_001180354.1  histone-lysine N-methyltransferase SUV39H2 isoform 2

    See identical proteins and their annotated locations for NP_001180354.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame, downstream AUG, and a shorter isoform (2) compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC069544, AL360083, BC007754, BU928392
    Consensus CDS
    CCDS7104.1
    UniProtKB/Swiss-Prot
    Q9H5I1
    Conserved Domains (2) summary
    cd10532
    Location:107349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:135
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  3. NM_001193426.2NP_001180355.1  histone-lysine N-methyltransferase SUV39H2 isoform 3

    See identical proteins and their annotated locations for NP_001180355.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate donor splice site at an internal coding exon compared to variant 1, maintaining the reading frame, and resulting in a shorter isoform (3) missing an internal protein segment compared compared to isoform 1.
    Source sequence(s)
    BC007754, BC029360
    Consensus CDS
    CCDS53493.1
    UniProtKB/Swiss-Prot
    Q9H5I1
    Related
    ENSP00000367576.3, ENST00000378325.7
    Conserved Domains (2) summary
    smart00317
    Location:100193
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam00385
    Location:4793
    Chromo; Chromo (CHRromatin Organisation MOdifier) domain
  4. NM_001193427.2NP_001180356.1  histone-lysine N-methyltransferase SUV39H2 isoform 4

    See identical proteins and their annotated locations for NP_001180356.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon, and uses an alternate donor splice site at an internal coding exon compared to variant 1. This results in translation initiation from an in-frame, downstream AUG, and a shorter isoform (4) missing an internal protein segment compared compared to isoform 1.
    Source sequence(s)
    BC007754, BU928392
    UniProtKB/Swiss-Prot
    Q9H5I1
    Related
    ENSP00000388968.1, ENST00000433779.5
    Conserved Domains (2) summary
    smart00317
    Location:40133
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam00385
    Location:233
    Chromo; Chromo (CHRromatin Organisation MOdifier) domain
  5. NM_024670.4NP_078946.1  histone-lysine N-methyltransferase SUV39H2 isoform 2

    See identical proteins and their annotated locations for NP_078946.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and is missing the subsequent exon compared to variant 1. This results in translation initiation from an in-frame, downstream AUG, and a shorter isoform (2) compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC069544, BC007754
    Consensus CDS
    CCDS7104.1
    UniProtKB/Swiss-Prot
    Q9H5I1
    Related
    ENSP00000319208.5, ENST00000313519.9
    Conserved Domains (2) summary
    cd10532
    Location:107349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:135
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

RNA

  1. NR_034181.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) is missing an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most supported translational start codon as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK225369, BC007754, DB040298
    Related
    ENST00000378331.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    14878866..14904315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016637.1XP_016872126.1  histone-lysine N-methyltransferase SUV39H2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H5I1
    Conserved Domains (2) summary
    cd10532
    Location:107349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:135
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  2. XM_011519662.2XP_011517964.1  histone-lysine N-methyltransferase SUV39H2 isoform X1

    See identical proteins and their annotated locations for XP_011517964.1

    UniProtKB/Swiss-Prot
    Q9H5I1
    Conserved Domains (2) summary
    cd10532
    Location:107349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:135
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  3. XM_006717503.3XP_006717566.1  histone-lysine N-methyltransferase SUV39H2 isoform X1

    See identical proteins and their annotated locations for XP_006717566.1

    UniProtKB/Swiss-Prot
    Q9H5I1
    Conserved Domains (2) summary
    cd10532
    Location:107349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:135
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
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