Format

Send to:

Choose Destination

NPEPL1 aminopeptidase like 1 [ Homo sapiens (human) ]

Gene ID: 79716, updated on 7-Jun-2020

Summary

Official Symbol
NPEPL1provided by HGNC
Official Full Name
aminopeptidase like 1provided by HGNC
Primary source
HGNC:HGNC:16244
See related
Ensembl:ENSG00000215440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bA261P9.2
Expression
Ubiquitous expression in fat (RPKM 17.5), spleen (RPKM 15.8) and 25 other tissues See more
Orthologs

Genomic context

See NPEPL1 in Genome Data Viewer
Location:
20q13.32
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (58689131..58715844)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (57264187..57290900)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985410 Neighboring gene STX16-NPEPL1 readthrough (NMD candidate) Neighboring gene syntaxin 16 Neighboring gene piezo type mechanosensitive ion channel component 1 pseudogene 2 Neighboring gene uncharacterized LOC105372695

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of aminopeptidase-like 1 (NPEPL1) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough STX16-NPEPL1

Readthrough gene: STX16-NPEPL1, Included gene: STX16

Homology

Clone Names

  • FLJ11583, FLJ42065

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloexopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
probable aminopeptidase NPEPL1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204872.2NP_001191801.1  probable aminopeptidase NPEPL1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses a distinct start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK307771, AL139349, BC020507, BP232534
    Consensus CDS
    CCDS56200.1
    UniProtKB/Swiss-Prot
    Q8NDH3
    Related
    ENSP00000434810.1, ENST00000525967.5
    Conserved Domains (1) summary
    cd00433
    Location:13459
    Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...
  2. NM_001204873.2NP_001191802.1  probable aminopeptidase NPEPL1 isoform 3

    See identical proteins and their annotated locations for NP_001191802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses a distinct start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK297667, AL139349, BC020507, BP232534
    Consensus CDS
    CCDS56201.1
    UniProtKB/Swiss-Prot
    Q8NDH3
    Related
    ENSP00000437112.1, ENST00000525817.5
    Conserved Domains (1) summary
    cd00433
    Location:6439
    Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...
  3. NM_024663.4NP_078939.3  probable aminopeptidase NPEPL1 isoform 1

    See identical proteins and their annotated locations for NP_078939.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL139349, BC020507, BM544905
    Consensus CDS
    CCDS46621.1
    UniProtKB/Swiss-Prot
    Q8NDH3
    Related
    ENSP00000348395.6, ENST00000356091.11
    Conserved Domains (1) summary
    cd00433
    Location:35487
    Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    58689131..58715844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center